DERMAGIC EXPRESS / Dermatologia y Bibliografia - Dermatology & bibliography: Finasteride 5 Mgr Vs 1 Mgr DERMAGIC EXPRESS / Dermatologia y Bibliografia - Dermatology & bibliography: Finasteride 5 Mgr Vs 1 Mgr
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jueves, 28 de agosto de 2025

CYPERUS ROTUNDUS AN HERB FOR ALOPECIA. / CYPERUS ROTUNDUS, UNA HIERBA PARA LA ALOPECIA.

 

THE CYPERUS ROTUNDUS A HERB THAT MAKES GROW HAIR. ! 

 

CYPERUS ROTUNDUS, UNA HIERBA QUE HACE CRECER EL CABELLO. !

 
Cyperus Rotundus y alopecia
 
PUBLICADO 2017-ACTUALIZADO 2025




EDITORIAL ENGLISH
==================

Hello DERMAGIC friends, the topic of today quite interesting: THE CYPERUS ROTUNDUS, An herb with medicinal properties.
 
Also known as TIRIRICA, and "NUTZ GRASS", plant that has been studied for many years, and to which They attribute numerous benefits to our body.

Maybe it's the first time you read about on this herb, but if you check the references well You will find that the CYPERUS ROTUNDUS L. (Cyperaceae) has been found Properties and benefits in clinical conditions such as:
 
 1.) DIABETES.
 2.) DIARRHEA.
 3.) INFLAMMATION.
 4.) MALARIA.
 5.) BOWEL INFLAMMATORY DISEASE.
 6.) HIRSUTISM.
 7.) NEUROPROTECTIVE.
 8.) CARDIOPROTECTION.
 9.) NEURODEGENERATIVE DISEASES (PARKINSON, ALZHEIMER).
 10.) PHOTO-AGING AND MELANOGENESIS.
 11.) HEPATOPROTECTIVE.
 12.) ANTICANCEROUS.
 13.) ANTILIPIDEMIC.
 14.) ANTIMUTAGENIC.
 15.) ANTI-UROPHATOGENIC.
 16.) OBESITY.
 17.) ANTIOXIDANT.
 18.) CONVULSIONS.
 19.) ANTIBACTERIAL.
 20.) ANTIANDROGENIC.

 21.) HYPERPIGMENTATION.
 22.) CANCER.   
 
In case you did not know CYPERUS ROTUNDUS is one of the most researched plant in the world due to the great concentration of active ingredients in the form of essential oils, phenolic acids, ascorbic acids and flavonoids in the tuber and rhizomes.

In some countries it is considered as a "bad herb" that does not let other plants grow well, and there are even works on how to eliminate Cyperus Rotundus in orchards and large fields for crops. But lately his PHYTOPROTECTION was demonstrated in fields contaminated with CRUDE OIL. 

This publication is not new, I did it years ago in the DERMAGIC EXPRESS, a colleague of BRAZIL, through A DERMATOLOGICAL LIST, made the comment that he had used the tubercles of this plant in Hydroalcohol solution with good results in ANDROGENIC ALOPECIA.

For that time, I did not find any scientific work on CYPERUS ROTUNDUS in ANDROGENIC ALOPECIA. Neither today, On the contrary, there are works of its use for HIRSUTISM by its antiandrogenic effect.

Based on the experience of this Dr. I went to a well-known pharmacist, DR. BERLIOZ, and I made the comment. The doctor formulated CYPERUS ROTUNDUS in the form of "CAPILLARY LOTION" and I tested it in several patients, men and women, the result was AWESOME, certainly the hair grew in both groups.

UPDATE 2025

Cyperus rotundus was later described as having ANTI-ANDROGENIC EFFECTS, so it is true that it helps or prevents hair loss in ANDROGENIC ALOPECIA, as explained in this article.

In addition, I found a study comparing it to the ALEXANDRITE LASER for body hair removal, thanks to its flavonoid content. This means that the laser promotes scalp regrowth, and the laser used in the oil formulation
prevents hair growth.

But it is ONLY ONE STUDY, which I will leave in the BIBLIOGRAPHIC references. The rest of the studies found speak of all its benefits, but officially, as of 2025, there are no scientific studies supporting its use in ANDROGENIC ALOPECIA.

CONCLUSIONS:

The question is: if CYPERUS ROTUNDUS has an anti-androgenic effect, why has it not been used or tested for ANDROGENIC ALOPECIA? Officially, why are there no scientific studies on the subject? It is considered an "Ayurvedic" medicine that has been used traditionally for many years, under the conditions we mentioned and also to promote
HAIR REGROWTH.

Could it be that "Big Pharma" DOESN'T benefit from a "common herb" causing them to reduce their multi-million dollar profits from FINASTERIDE, DUTASTERIDE and MINOXIDIL ?
 
This publication is dedicated to all RESEARCHERS, colleagues and patients, with the following message:

 "...Tubers of CYPERUS ROTUNDUS, crushed and extracted their chemical compounds and prepared in hydroalcoholic or oily solution are useful in ANDROGENIC ALOPECIA ..."

An herb that you get in parks and even the garden of your house ...

"MOTHER NATURE PLACES ON OUR WAY, THE PATHS TO CURE OUR ILLNESSES, CYPERUS ROTUNDUS IS ONE OF THEM. "..

In the references the facts, in the attach: THE CYPERUS ROTUNDUS.
 


Cyperus Rotundus and alopecia


Greetings to all.

Dr, Jose Lapenta.
Dr. José M. Lapenta. 



EDITORIAL ESPAÑOL  
================= 
Hola amigos DERMAGICOS, el tema de hoy bastante interesante: EL CYPERUS ROTUNDUS, una hierba con propiedades medicinales. 
 
También conocida bajo el nombre de TIRIRICA, y "HIERBA DE LA NUEZ" o "COROCILLO", planta que viene siendo estudiada desde hace muchos años, y a la cual se le atribuyen numerosos beneficios en nuestro organismo.

Quizás es la primera vez que lees algo sobre esta hierba, pero si revisas bien las referencias bibliográficas te encontraras que el CYPERUS ROTUNDUS L. (Cyperaceae) se le han encontrado propiedades y beneficios en condiciones clínicas como:

1.) DIABETES.
2.) DIARREA.
3.) INFLAMACIÓN.
4.) MALARIA.
5.) ENFERMEDAD INFLAMATORIA INTESTINAL.
6.) HIRSUTISMO.
7.) NEUROPROTECCION.
8.) CARDIOPROTECCION.
9.) ENFERMEDADES NEURO-DEGENERATIVAS (PARKINSON, ALZHEIMER).
10.) FOTOENVEJECIMIENTO Y MELANOGENESIS.
11.) HEPATO-PROTECTOR.
12.) ANTICANCEROSO.
13.) ANTILIPIDEMICO.
14.) ANTIMUTAGENICO.
15.) ENFERMEDADES DE VÍAS URINARIAS.
16.) OBESIDAD.
17.) ANTIOXIDANTE.
18.) CONVULSIONES.
19.) ANTIBACTERIANO.
20.) ANTI-ANDROGÉNICO.
 
21.) HIPERPIGMENTACION. 
22.) CANCER.  

Por si no lo sabias EL CYPERUS ROTUNDUS es una de las plantas más investigada en todo el mundo debido a la GRAN concentración de ingredientes activos en forma de aceites esenciales, ácidos fenólicos, ácidos ascórbicos y flavonoides en el tubérculo y rizomas.

En algunos países es considerado como una "hierba mala" que no deja crecer bien otras plantas, e incluso hay trabajos de como eliminar el         Cyperus Rotundus en algunos sembradíos. Pero últimamente se demostró su FITOPROTECCION en campos contaminados con PETROLEO.

Esta publicación no es nueva, la hice hace años en el DERMAGIC EXPRESS, una colega de BRASIL, a través de una LISTA DERMATOLOGICA, hizo el comentario de que había utilizado los tubérculos de esta planta en solución hidro-alcoholica con buenos resultados en la ALOPECIA ANDROGÉNICA.  

Para esa época no encontré ningún trabajo científico sobre el CYPERUS ROTUNDUS en ALOPECIA ANDROGÉNICA. Hoy tampoco, al contrario hay trabajos de su uso para el HIRSUTISMO por su efecto anti-androgénico.

Basado en la experiencia de esta Dra. fui donde un farmaceuta conocido, DR. BERLIOZ, y le hice el comentario. El Dr. formulo EL CYPERUS ROTUNDUS en forma de "LOCIÓN CAPILAR" y lo probé en varios pacientes, hombres y mujeres, el resultado fue IMPRESIONANTE, ciertamente el cabello creció en ambos grupos.

ACTUALIZACION 2025 
 
El Cyperus Rotundus se le describió posteriormente su EFECTO ANTI-ANDROGÉNICO, por lo tanto, si es cierto que ayuda o previene la caída del cabello en la alopecia ANDROGÉNICA, tal como ha sido explicado en este articulo.
 
Pero ademas de ello encontré un estudio donde se le compara con el LASER DE ALEXANDRITA,  para la depilación del cuerpo, gracias a su contenido de flavonoides, es decir, el en el cuero cabelludo promueve la REPOBLACIÓN y el el cuerpo según ese estudio usado en formulación de aceite evita la salida del vello. !!!!
 
Pero es SOLO UN ESTUDIO, el cual te dejare en las referencias BIBLIOGRÁFICAS, de resto los estudios encontrados, hablan de todos sus beneficios, pero oficialmente para hoy 2025 no hay estudios científicos que avalen su uso en ALOPECIA ANDROGÉNICA
 

CONCLUSIONES:
 
La pregunta es la siguiente: si el CYPERUS ROTUNDUS tiene efecto anti-androgénico, porque no ha sido utilizado o experimentado en la ALOPECIA ANDROGÉNICA. ??  oficialmente, porque no hay estudios científicos al respecto ?. cuando es considerada una medina "ayurvédica" de uso tradicional desde hace muchos años, en las condiciones que mencionamos y también para promover la REPOBLACIÓN DEL CABELLO.
 
Sera que a la "Big Pharma" NO LE CONVIENE que una "vulgar hierba" les haga disminuir sus millonarias ganancias con FINASTERIDE, DUTASTERIDE, y MINOXIDIL. ?'?
 
 Esta publicación va dedicada a todos los INVESTIGADORES, colegas y pacientes, con el siguiente mensaje:

..." Los tubérculos del CYPERUS ROTUNDUS, triturados y extraídos sus componentes químicos y preparados en solución hidroalcoholica u oleosa son útiles en la ALOPECIA ANDROGÉNICA..."

Una hierba que la consigues en parques y hasta el jardín de tu casa...

"LA MADRE NATURALEZA NOS PONE EN EL CAMINO, VÍAS PARA CURAR NUESTRAS ENFERMEDADES,  EL CYPERUS ROTUNDUS ES UNA DE ELLAS.." 

En las referencias los hechos, en el adjunto: EL CYPERUS ROTUNDUS.

Saludos a todos.

Dr. José Lapenta.
Dr. José M. Lapenta. 



================================================================== 
REFERENCIAS BIBLIOGRÁFICAS / BIBLIOGRAPHICAL REFERENCES 
================================================================== 
A.- Topical Cyperus rotundus oil: a new therapeutic modality with comparable efficacy to Alexandrite laser photo-epilation (2014).  
E.- The treatment role of Cyperus rotundus L. to triple-negative breast cancer cells (2019).
================================================================== 
 1.) TIRIRICA / CYPERUS ROTUNDUS
2.) Table-maker: Phytochemicals of Cyperus rotundus
3.) Cyperus rotundus L. (CYPERACEAE) (SEDGE FAMILY)
"Purple nutsedge" "Sa'ad" "hasir" "si'd"
4.) TIRIRICA Cyperus rotundus
5.) BALAKALPAM (PRODUCT NO 1 WITH CYPERUS ROTUNDUS)
6.) HEPATONE (PRODUCT NO 2 WITH CYPERUS ROTUNDUS)
7.) Cyperus rotundus L. / Healthcare Properties
8.) The ameliorating effects of the cognitive-enhancing chinese herbs on
scopolamine-induced amnesia in rats.
9.) Rotundines A-C, three novel sesquiterpene alkaloids from Cyperus rotundus.
10.) Effect of feeding tagernut (Cyperus rotundus, L) meal on the performance of rabbits.
11.) Antimalarial sesquiterpenes from tubers of Cyperus rotundus: structure of
10,12-peroxycalamenene, a sesquiterpene endoperoxide.
12.) [Effects of the combination of Astragalus membranaceus (Fisch.) Bge. (AM),Angelica sinensis
(Oliv.) Diels (TAS), Cyperus rotundus L. (CR), Ligusticum chuangxiong Hort (LC) and Peaonia
veitchii lynch (PV) on the
hemorheological changes in "blood stagnating" rats].
13.) [Revision on the type of leaf trace bundles of Cyperus rotundus L].
14.) [Effects of the combination of Astragalus membranaceus (Fisch.) Bge. (AM),tail of Angelica
sinensis (Oliv.) Diels. (TAS), Cyperus rotundus L. (CR),Ligusticum chuanxiong Hort. (LC) and
Paeonia veitchii Lynch (PV) on the
hemorrheological changes in normal rats].
15.) [Treatment of intestinal metaplasia and atypical hyperplasia of gastric
mucosa with xiao wei yan powder].
16.) Monitoring and assessment of mercury pollution in the vicinity of a
chloralkali plant. IV. Bioconcentration of mercury in in situ aquatic and
terrestrial plants at Ganjam, India.
17.) Antimalarial compounds containing an alpha,beta-unsaturated carbonyl moiety from Tanzanian
medicinal plants.
18.) Antimalarial activity of Tanzanian medicinal plants.
19.) Effect of Nagarmotha (Cyperus rotundus Linn) on reserpine-induced emesis in pigeons.
20.) Pharmacological studies to isolate the active constituents from Cyperus
rotundus possessing anti-inflammatory, anti-pyretic and analgesic activities.
21.) Characterization of ferredoxin from nutsedge, Cyperus rotundus L., and
other species with a high photosynthetic capacity.
22.) A pharmacological study of Cyperus rotundus.
23.) CYPERUS ROTUNDUS L. ROOT OIL
24.) POSSIBILITIES OF SOIL SOLARIZATION FOR THE ERRADICATION OF Cyperus
rotundus L. AND THE IMPROVEMENT OF SALINE SOILS
25.) Control Of Nut Grass (Cyperus Rotundus) In Asparagus.
26.) Neuroprotective and cognitive-enhancing effects of the combined extract of Cyperus rotundus and Zingiber officinale.
27.) Novel Food Supplement "CP1" Improves Motor Deficit, Cognitive Function, and
Neurodegeneration in Animal Model of Parkinson's Disease.
28.) Effect of Cyperus Rotundus on Cytokine Gene Expression in Experimental Inflammatory Bowel Disease.
29.) α-Cyperone of Cyperus rotundus is an effective candidate for reduction of inflammation by destabilization of microtubule fibers in brain.
30.) Identification of Neuroactive Constituents of the Ethyl Acetate Fraction from Cyperi Rhizoma Using Bioactivity-Guided Fractionation.
30.) Isocyperol, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced inflammatory responses via suppression of the NF-κB and STAT3 pathways and ROS stress in LPS-stimulated
RAW 264.7 cells.
31.) Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells.
32.) New Iridoid Glycosides with Antidepressant Activity Isolated from Cyperus rotundus.
32.) Antidiabetic activity of ethanolic extract of Cyperus rotundus rhizomes in streptozotocin-induced diabetic mice.
33.) LC-ESI-MS/MS analysis of total oligomeric flavonoid fraction of Cyperus rotundus and its antioxidant, macromolecule damage protective and antihemolytic effects.
34.) Cyperus rotundus L.: Traditional uses, phytochemistry, and pharmacological activities.
35.) 6-Acetoxy Cyperene, a Patchoulane-type Sesquiterpene Isolated from Cyperus rotundus Rhizomes Induces Caspase-dependent Apoptosis in Human Ovarian Cancer Cells.
36.) Cyperus rotundus L. prevents non-steroidal anti-inflammatory drug-induced gastric mucosal damage by inhibiting oxidative stress.
37.) Solanioic Acid, an Antibacterial Degraded Steroid Produced in Culture by the Fungus Rhizoctonia solani Isolated from Tubers of the Medicinal Plant Cyperus rotundus.
38.) Structurally diverse terpenoids from the rhizomes of Cyperus rotundus L.
39.) New cycloartane glycosides from the rhizomes of Cyperus rotundus and their antidepressant activity.
40.) Investigation on Chinese herbal medicine for primary dysmenorrhea: implication from a nationwide prescription database in Taiwan.
41.) Topical Cyperus rotundus oil: a new therapeutic modality with comparable efficacy to Alexandrite laser photo-epilation.
 
42.) Phytoremediation of crude oil contaminated soil using nut grass, Cyperus rotundus.
============================================================

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lunes, 11 de agosto de 2025

FINASTERIDE 5 MG AND 1 MG IN ANDROGENIC ALOPECIA. / FINASTERIDE 5 MG Y 1 MG EN ALOPECIA ANDROGENICA.


 Finasteride 5 Mgr vs 1 Mgr in Androgenic Alopecia. !


Finasteride 5 Mgr vs 1 Mgr en Alopecia Androgénica. !


Finasteride y alopecia androgenica


 

 EDITORIAL ENGLISH
 =================== 
Hello friends of the DERMAGIC network, back with a very hot topic: FINASTERIDE 5 MG VS FINASTERIDE 1 MG IN ANDROGENIC ALOPECIA.

The first article I found on this drug dates back to 1993, and others from 1994 discussed 
FINASTERIDE as a promising drug for various conditions such as acne, HIRSUTISM, PROSTATE CANCER and BENIGN PROSTATIC HYPERPLASIA (BPH).

Later, it was discovered that finasteride was and is useful in the treatment of androgenetic alopecia.

But at that time, only the 5 MG version (PROSCAR) was available, and many people began using it twice a week: they would break the original pill into 4 parts, taking 1/4 of a pill daily. This motivated the company to market the 1 mg dosage form for exclusive use in ANDROGENIC ALOPECIA, under the name PROPECIA.

There are studies in which patients were given 5 mg 
FINASTERIDE daily for 2 years without side effects. Furthermore, the first report from 1993 showed that daily doses of 80 mg FINASTERIDE for 3 months caused no side effects.

However, subsequent studies showed that at doses of 1 mg, 
FINASTERIDE (PROPECIA), like all medications, has its side effects, mainly erectile dysfunction, mood swings, decreased semen volume, and in some cases, gynecomastia  and adenomas.

These reports appeared during the decade from 2010 to 2012, describing the so-called
POST-FINASTERIDE SYNDROME (PFS): which is still being discussed today, with symptoms that appear after prolonged treatment with this medication. I describe them as follows:

Symptoms included:

- Decreased libido.
- Erectile dysfunction.
- Changes in penile tissue.
- Loss of enjoyment or desire for sexual intercourse.
- Decreased sperm count.
- Gynecomastia, adenomas.
- Skin changes.
- Cognitive impairment: loss of memory and concentration.
- Fatigue.
- Anxiety, panic attacks.
- Depression.
- Suicidal ideation.
- Loss of muscle mass.
- Metabolic disorders.

MECHANISM PRODUCING THIS SYNDROME:

1.) FINASTERIDE inhibits the enzyme 5-alpha reductase type 2, blocking the conversion of testosterone to dihydrotestosterone (DHT), which is its main effect. This would cause an alteration in the levels of neuroactive steroids that regulate neurotransmitters such as GABA and serotonin in the brain.

2.) Alterations in hippocampal neurogenesis and changes in the gut microbiota that could influence symptoms have been detected.

3.) Genetic susceptibility and changes in androgen receptors and enzymes could be involved in the clinical manifestations.

Although this POST FINASTERIDE SYNDROME is documented and recognized by patients, it remains a topic of debate in the medical community today.

Among cases of female pattern baldness, 
FINASTERIDE was significantly more common with fetal damage and uterine disorders. Furthermore, drug-gene network analysis indicated that finasteride could profoundly alter pathways related to sex hormone signaling and oocyte maturation.

It was later discovered that 
FINASTERIDE is not useful in FEMALE pattern baldness, but is useful in HIRSUTISM.

HISTORICAL ACCOUNT:

Since it became known in the scientific world that 
FINASTERIDE produced hair growth, FINASTERIDE 5 mg (PROSCAR) began to be used, as I mentioned before, because FINASTERIDE 1 mg (PROPECIA) had not yet been marketed. The dosage: 10 mg weekly in 2 doses, Tuesdays and Thursdays, with good results.

Once FINASTERIDE 1 MG (PROPECIA) was released, the company began an
AGGRESSIVE CAMPAIGN, stating that the dose had to be 1 MG daily for 7 days a week, which would be 7 MG total, versus the 10 MG twice weekly doses of FINASTERIDE 5 MG (PROSCAR).

The TRUTH is that
FINASTERIDE 5 MG twice weekly is as good as or equal to FINASTERIDE 1 MG daily, and it's much cheaper, safer, and has fewer risks. A box of 30 tablets lasts 15 weeks (3 months and 3 weeks).

Perhaps one of the advantages that can be attributed to this regimen is that your body "rests" from the drug because you only take it twice a week, compared to taking 
FINASTERIDE 1 mg (PROPECIA) daily, from which your body doesn't rest; you always have the medicine "inside."

I went for the scientific route and used 
FINASTERIDE 5 mg in patients with androgenetic alopecia with the aforementioned regimen: 5 mg twice a week. After the fourth month, I observed significant improvement in the patients. See the attached photos.

CONCLUSIONS:

1.) 
FINASTERIDE is a wonderful product.

2.) 
FINASTERIDE5 mg twice a week is better than or equal to finasteride 1 mg daily.

3.) Merck S.D. launched PROPECIA for commercial and marketing purposes.

4.) FINASTERIDE IMPROVES BENIGN PROSTATIC HYPERPLASIA (BPH), AND PRODUCES notable improvement in ANDROGENIC ALOPECIA...!!!

5.)
TOPICAL FINASTERIDE, under the name FINASTOPIC, was be marketed by ISDIN in 2024. This has been talked about since 2000; the topical formulation most likely has fewer side effects than the oral formulation. In some presentations it comes combined with the popular MINOXIDIL, which is also useful in hair loss.

Finally, FINASTERIDE has recently been used in the treatment of
HIDRADENITIS SUPURATIVA, in both men and women, with good results. Its use as a hormonal agent is also proposed for the treatment of acne.

And its competition also emerged: DUTASTERIDE, which, in addition to being an oral formulation, comes in ampoules for local injection into the scalp. This formulation is the most commonly used, as the oral formulation is not officially approved for the treatment of this condition and is used off-label, given the beneficial clinical effects obtained.

Here is the link to the update on SERENOA REPENS or SAW PALMETTO versus FINASTERIDE for ANDROGENIC ALOPECIA.

In these references, you will learn about FINASTERIDE, its uses, and some of its adverse effects.

Greetings to all.

Dr, José Lapenta. 
Dr, José M.  Lapenta.  


Finasteride 5 Mg en Alopecia Androgenica



























 EDITORIAL ESPAÑOL
===================
Hola amigos de la red DERMAGIC, de nuevo con ustedes con un tema bien caliente: FINASTERIDE 5 MG VS FINASTERIDE 1 MG EN ALOPECIA ANDROGENICA.
 
 El primer trabajo que encontré sobre esta droga data del año 1.993 y otros mas de 1.994 donde se hablaba del FINASTERIDE COMO UNA DROGA promisoria en algunas PATOLOGÍAS COMO Acné, Hirsutismo, Cáncer de Próstata e  Hiperplasia prostatica benigna (BHP). 

Posteriormente se descubrió que el FINASTERIDE era y es útil en el tratamiento de  la ALOPECIA ANDROGÉNICA.
 
Pero para esa fecha solo existía la presentación de 5 MG, (PROSCAR), y mucha gente lo comenzó a usar 2 VECES por semana:  picaba la pastilla original en 4 PARTES, para tomar 1/ 4 de pastilla diaria. Esto motivo al laboratorio a sacar al mercado la presentación de 1 MG para su uso exclusivo en la ALOPECIA ANDROGÉNICA, con el nombre de PROPECIA.

EXISTEN estudios donde a pacientes se les dio FINASTERIDE 5 MGRS DIA POR 2 AÑOS SIN EFECTOS COLATERALES, MAS AUN,, en el primer reporte de 1.993 se DEMOSTRÓ que dosis diarias de 80 MGR /dia de FINASTERIDE por 3 meses NO OCASIONABAN EFECTOS SECUNDARIOS.
 
Pero en estudios posteriores se comprobó que a dosis de 1 MG, el FINASTERIDE, (PROPECIA), como todo medicamento tiene sus efectos secundarios principalmente LA DISFUNCIÓN ERÉCTIL, cambios en el humor, disminución del volumen del semen, y en algunos casos GINECOMASTIA Y ADENOMAS. 
 
Estos reportes aparecieron para la decada del 2010 al 2012 describiéndose el llamado SÍNDROME POST FINASTERIDE (SPF): el cual es discutido hoy en dia, con síntomas que se presentan luego de tratamientos prolongados con este medicamentos y te describo: 
 
Los síntomas incluyeron:
 
- Disminución de la libido.
- Disfunción eréctil.
- Cambios en el tejido del pene. 
- Perdida del disfrute o deseo por la relación sexual.
- Disminución del recuento de espermatozoides.
- Ginecomastia, adenomas.
- Cambios en la piel.
- Deterioro cognitivo: perdida de la memoria y concentración. 
- Fatiga.
- Ansiedad, ataques de pánico. 
- Depresión.
- Ideación suicida. 
- Perdida de masa muscular.
- Trastornos metabólicos. 
 
MECANISMO PRODUCTOR DE ESTE SÍNDROME: 
 
1.) El FINASTERIDE inhibe la enzima 5-alfa reductasa tipo 2, bloqueando la conversión de testosterona a dihidrotestosterona (DHT), ese es su principal EFECTO, esto provocaría una alteración de los niveles de esteroides neuroactivos que regulan neurotransmisores como GABA y serotonina en el cerebro.
 
2.) Se ha detectado alteración en la neuro génesis del hipocampo y cambios en la microbiota intestinal que podrían influir en los síntomas.
 
3.) La susceptibilidad genética y cambios, en receptores androgénicos y enzimas, pudieran estar implicados en las manifestaciones clínicas..

A pesar de que este
SÍNDROME POST FINASTERIDE esta documentado y reconocido por pacientes, hoy dia sigue siendo un tema de debate en la comunidad medica.
 
Entre los casos de alopecia femenina, EL FINASTERIDE fue significativamente más concurrente con el daño al feto y el trastorno del útero. Además, el análisis de la red de fármacos-genes indicó que el FINASTERIDE podría alterar profundamente las vías relacionadas con la señalización de las hormonas sexuales y la maduración de los ovocitos. 
 
Posteriormente se descubrió que el FINASTERIDE no es ÚTIL en la ALOPECIA ANDROGÉNICA femenina, pero si en el HIRSUTISMO.

RECUENTO HISTÓRICO:

Desde que se conoció en el mundo científico QUE EL FINASTERIDE producía crecimiento del cabello, comenzó a usarse el FINASTERIDE 5 MG (PROSCAR), como antes les mencione, porque el FINASTERIDE 1 MG (PROPECIA) no había salido al mercado. La dosis: 10 MG SEMANALES en 2 dosis, martes y jueves con BUEN RESULTADO. 

Una vez que salio al mercado el FINASTERIDE 1 MG, (PROPECIA), el laboratorio comenzó una CAMPAÑA AGRESIVA, diciendo que la dosis tenia que ser un 1 MG dia por 7 días a la semana, que serian 7 MG en total, versus los 10 MG en las 2 tomas semanales del FINASTERIDE 5 MG (PROSCAR). 

La VERDAD es que FINASTERIDE 5 MG 2 VECES SEMANAL es tan bueno o igual al FINASTERIDE 1 MG DIARIO, y el costo es muchísimo menor, mas seguro, menos riesgos. Una caja de 30 Tabs dura 15 semanas, (3 meses y 3 semanas). 
 
 Quizá una de las ventajas que puede atribuirsele a este esquema es que tu organismo ¨descansa¨ de la droga pues solo la tomas 2 veces semanal, en relación al FINASTERIDE 1 MG (PROPECIA) diario, del cual tu organismo no descansa, siempre tienes la medicina ¨adentro¨. 

Yo me fui por el lado científico y utilice el producto FINASTERIDE 5 MG       en pacientes con Alopecia Androgénica con el esquema antes dicho 5 MG 2 veces semanal y al 4to mes observe mejoría notable de los pacientes, vean las fotos del attach.

CONCLUSIONES:

1.) EL FINASTERIDE ES UN producto maravilloso. 

2.) EL FINASTERIDE 5 MG 2 veces semanal, es MEJOR o IGUAL que el FINASTERIDE 1 MG  DIARIO. 

3.) EL LABORATORIO MERCK.S.D LANZO la PROPECIA con fines COMERCIALES Y DE MERCADEO. 

4.)  EL FINASTERIDE MEJORA LA HIPERPLASIA PROSTÁTICA BENIGNA (HPB), Y PRODUCE mejoría notable en la ALOPECIA ANDROGÉNICA.. !!! 

5.) PARA el año 2024, salio al mercado el
FINASTERIDE TÓPICO, con el nombre de FINASTOPIC, por el laboratorio ISDIN. De esto se venia hablando desde el año 2000, muy probablemente la presentación tópica tiene menos efectos secundarios que la presentación oral; en algunas presentaciones viene combinado con el popular MINOXIDIL, el cual también es útil en la caída del cabello.
  
Para finalizar el FINASTERIDE a sido utilizado últimamente en el tratamiento de la HIDRADENITIS SUPURATIVA, tanto en hombres como mujeres con buen resultado. También se propone su uso como agente hormonal en el tratamiento del Acné.
 
Y también le salio su competencia: EL DUTASTERIDE,  el cual ademas de presentación oral, viene en ampollas para inyección local en el cuero cabelludo, siendo esta presentación la mas utilizada, pues la PRESENTACIÓN ORAL NO ESTA APROBADA OFICIALMENTE  para el tratamiento de esta patología, mas se usa off label, dado los efectos clínicos beneficiosos obtenidos.
 
Aquí te dejo el enlace a la actualización de la SERENOA REPENS o SAW PALMETTO versus el FINASTERIDE en la ALOPECIA ANDROGÉNICA. 

En estas referencias conocerás el FINASTERIDE , sus usos y algunos de sus efectos adversos. 

Saludos a todos ! 

Dr. José Lapenta.. 
Dr. José M. Lapenta.. 


================================================================== 
REFERENCIAS BIBLIOGRÁFICAS / BIBLIOGRAPHICAL REFERENCES 
================================================================== 

 F.- Relative safety and efficacy of finasteride for treatment of hirsutism (2004).
====================================================================         
1.) Five-year follow-up of patients with benign prostatic hyperplasia treated with  finasteride. 
2.) Therapeutic effects of finasteride in benign prostatic hyperplasia: a randomized  double-blind controlled trial. 
3.) The effect of finasteride on prostate volume, urinary flow rate and symptom score in  men with benign prostatic hyperplasia. 
4.) [5-alpha-reductase inhibitors]. 
5.) Benign prostatic hyperplasia. 
6.) The potential for hormonal prevention trials. 
7.) 5 alpha-reductase inhibition by finasteride (Proscar) in epithelium and stroma of human  benign prostatic hyperplasia. 
8.) Pharmacological treatment of benign prostatic hyperplasia with finasteride: a clinical  review. 
9.) Medical therapy for benign prostatic hyperplasia: A review of the literature. 
10.) Pretreatment with finasteride decreases perioperative bleeding associated with  transurethral resection of the prostate. 
11.) Urinary retention in patients with BPH treated with finasteride or placebo over 4  years. Characterization of patients and ultimate outcomes.The PLESS Study Group. 
12.) Dihydrotestosterone and the concept of 5alpha-reductase inhibition in human benign  prostatic hyperplasia. 
13.) Chronic treatment with finasteride daily does not affect spermatogenesis or semen  production in young men. 
14.) Management of androgenetic alopecia. 
15.) Finasteride in the treatment of men with frontal male pattern hair loss. 
16.) Androgenetic alopecia in men: the scale of the problem and prospects for treatment. 
17.) [Androgenetic alopecia, hirsutism and hypertrichosis]. 
18.) Medical treatments for balding in men. 
19.) Understanding and managing common baldness. 
20.) Finasteride: a review of its use in male pattern hair loss. 
21.) Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male  Pattern Hair Loss Study Group. 
22.) Genetic analysis of male pattern baldness and the 5alpha-reductase genes. 
23.) Effect of finasteride on human testicular steroidogenesis. 
24.) [Finasteride: a new drug for the treatment of male hirsutism and  androgenetic  alopecia]? 
25.) The 5 alpha-reductase system and its inhibitors. Recent development and its  perspective in treating androgen-dependent skin disorders. 
26.) Finasteride: a clinical review. 
27.) The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and  dihydrotestosterone concentrations in patients with male pattern baldness. 
28.) Finasteride: the first 5 alpha-reductase inhibitor. 
29.) Cytologic atypia in a 53-year-old man with finasteride-induced gynecomastia. 
30.) Reversible painful gynaecomastia induced by low dose finasteride (1 mg/day). 
31.) Measuring reversal of hair miniaturization in androgenetic alopecia by follicular counts 
in horizontal sections of serial scalp biopsies: results of finasteride 1 mg treatment of men  and postmenopausal women. 
32.) Improvement in androgenetic alopecia in 53-76-year-old men using oral finasteride. 
33.) New topical antiandrogenic formulations can stimulate hair growth in human bald  scalp grafted onto mice. 
34.) Current management of androgenetic alopecia in men. 
35.) Immunohistochemical localization of types 1 and 2 5alpha-reductase in human scalp. 
36.) The psychosocial consequences of androgenetic alopecia: a review of the research  literature. 
37.) Clinical dose ranging studies with finasteride, a type 2 5alpha-reductase inhibitor, in  men with male pattern hair loss. 
38.) The effects of finasteride on scalp skin and serum androgen levels in men with  androgenetic alopecia. 
39.) Adverse Effects and Safety of 5-alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review.
40.) Interventions for Female Pattern Hair Loss.
41.) Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases.
42.) Finasteride in Hidradenitis Suppurativa: A "Male" Therapy for a Predominantly "Female" Disease.
43.) Hidradenitis suppurativa treated with finasteride.
44.) The use of hormonal agents in the treatment of acne.
45.) Risk of gynecomastia and breast cancer associated with the use of 5-alpha reductase inhibitors for benign prostatic hyperplasia.
46.) Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome.
47.) Post-Finasteride Adverse Effects in Male Androgenic Alopecia: A Case Report of Vitiligo.
48.) Side Effects Related to 5 α-Reductase Inhibitor Treatment of Hair Loss in Women: A Review.
49.) 5 mg/day finasteride treatment for normoandrogenic Asian women with female pattern hair loss.
50.) Adverse effects of 5α-reductase inhibitors: What do we know, don't know, and need to know?
============================================================= 

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miércoles, 9 de julio de 2025

SERENOA REPENS AND FINASTERIDE IN ANDROGENIC ALOPECIA. / SERENOA REPENS Y FINASTERIDE EN ALOPECIA ANDROGENICA.



Serenoa Repens vs Finasteride in Androgenic Alopecia.

 Serenoa Repens vs Finasteride en alopecia Androgénica.


La serenoa repens en la alopecia androgenica

 

 


EDITORIAL ENGLISH
==================
Hello friends of the network, DERMAGIC is back with you again. Today's topic: SERENOA REPENS VS FINASTERIDE in ANDROGENIC ALOPECIA.

When the FINASTERIDE molecule was launched on the market, perhaps it was not thought that a medicine with similar or identical characteristics already existed, with the only difference being that this one is a plant.

SAW PALMETTO BERRIES, better known as SERENOA REPENS or SABAL SERRULATA, have been shown through scientific studies to be useful for both hair loss and Benign Prostatic Hyperplasia (BPH).

If we examine these bibliographic references carefully, we find the following:

SERENOA REPENS:

1.) It has the same properties as FINASTERIDE in reducing prostate symptoms, perhaps not as potent as FINASTERIDE, but still useful.

2.) It inhibits isoenzymes 1 and 2 in the prostate.

3.) It has anti-inflammatory effects on the prostate.

4.) It lowers DHT (dihydrotestosterone) levels, which is responsible for Androgenetic Alopecia, because it inhibits 5-alpha reductase.

5.) It has been used topically and orally against 
Androgenetic Alopecia.

6.) And it obviously has fewer side effects than FINASTERIDE.

With these main characteristics, we must consider that

1.) Saw palmetto also has effects like FINASTERIDE against 
Androgenetic Alopecia.

2.) These two medicines, one NATURAL
(SERENOA REPENS = SABAL SERRULATA), the other CHEMICAL (FINASTERIDE), boths are useful in Prostatic Hyperplasia, improving the symptoms of enlargement, because both have been proven to inhibit the 5-alpha reductase enzyme, decreasing DHT levels.

3.)
SAW PALMETTO or SERENOA REPENS (SABAL SERRULATA) is now considered an ANTI-ANDROGENIC herb.

One of the reasons you might want to use SERENOA REPENS for the treatment of 
Androgenetic Alopecia, is to avoid the SIDE EFFECTS OF FINASTERIDE, primarily sexual dysfunction.

On the other hand, FINASTERIDE has been tested TOPICALLY, with good results for both 
Androgenetic Alopecia in men and HIRSUTISM in women, thus avoiding the effects of sexual dysfunction.

However, its commercial presentation was officially launched in November 2024 under the name
FINASTOPIC, from the ISDIN laboratory. Although its topical use has been studied since the 2010s.

In my opinion, finasteride is a great molecule for the treatment of androgenetic alopecia and benign prostatic hyperplasia (BHP). However, for those who wish to use or try Serenoa repens as a natural therapeutic alternative, this is a valid option.

Finally: A study was conducted that showed that KETOCONAZOLE shampoo locally reduces DHT. It could be used in conjunction with FINASTERIDE or SERENOA REPENS for 
Androgenetic Alopecia (reference 60).

I remind you that there is another molecule similar to FINASTERIDE called
DUTASTERIDE. Unlike dutasteride, this one, in addition to being presented in tablets, also comes in ampoules for local infiltration into the scalp. However, IT HAS NOT BEEN OFFICIALLY APPROVED for use in Androgenetic Alopecia, but widely used for its beneficial effects demonstrated in published articles.
 


These references contain the facts...

Greetings to all!!!

Dr. Jose Lapenta.



EDITORIAL ESPAÑOL

==================
Hola Amigos de la red, DERMAGIC de nuevo con ustedes, El tema de hoy: SERENOA REPENS VS FINASTERIDE en ALOPECIA ANDROGÉNICA. 
 
Cuando la molécula FINASTERIDE fue lanzada al mercado quizá no se pensó que ya existía una medicina con similares o iguales características, con la única diferencia que esta es una planta.
 
LAS CEREZAS O BAYAS DEL SAW PALMETTO, mejor conocida como SERENOA REPENS o SABAL SERRULATA,  la cual ha demostrado a través de estudios científicos que es útil tanto en la caída del cabello como la Hiperplasia Prostatica Benigna (BHP). 

Si examinamos bien estas referencias bibliográficas nos encontramos con lo siguiente:  


LA SERENOA REPENS:  

1.) Tiene iguales propiedades al FINASTERIDE en disminución de la sintomatología prostática, quizá no tan potente como el FINASTERIDE, pero si es útil. 

2.) INHIBE LAS izoenzimas 1 y 2 a nivel de la próstata. 

3.) Tiene efectos antiinflamatorios a nivel prostático. 

4.) Disminuye el nivel de la DHT (dihidrotestosterona), la responsable de la Alopecia Androgénica porque INHIBE la 5 alfa-reductasa. 

5.) Ha sido utilizada en forma TOPICA como oral contra la Alopecia Androgénica.

6.) Y obviamente tiene menos efectos secundarios que el FINASTERIDE.  


Con estas característica principales debemos pensar que  

1,) LA SERENOA REPENS también tiene EFECTOS como el FINASTERIDE contra la Alopecia Androgénica. 

2.) Estas dos medicinas, una NATURAL (EL SAW PALMETTO=SERENOA REPENS=SABAL SERRULATA), otra QUÍMICA (FINASTERIDE) son útiles en la hiperplasia prostática mejorando los síntomas del agrandamiento, porque se comprobó que ambas inhiben la enzima 5 alfa reductasa disminuyendo los niveles de DHT. 

3.) El SAW PALMETTO o SERENOA REPENS (SABAL SERRULATA), hoy en dia   es considerada una planta ANTI-ANDROGENOS. 

Una de las razones que te puede conducir a utilizar LA SERENOA REPENS para el tratamiento de la Alopecia Androgénica, es evitar los EFECTOS SECUNDARIOS DEL FINASTERIDE, principalmente la disfunción sexual.

Por otra parte el FINASTERIDE ha sido probado en forma TOPICA, con buenos resultados tanto en la Alopecia Androgénica  en hombres, como el HIRSUTISMO en las mujeres, evitando asi los efectos de la disfunción sexual. 
 
Pero su presentación comercial fue oficialmente lanzada al mercado en Noviembre del 2024 con el nombre de FINASTOPIC, del laboratorio ISDIN, aunque su uso tópico se viene estudiado desde la decada del 2010.
 
 
En mi opinion EL FINASTERIDE ES una gran MOLÉCULA para el tratamiento de la Alopecia Androgénica y la Hiperplasia Prostatica Benigna,(BHP), pero aquellos que desean usar o probar la SERENOA REPENS como alternativa terapéutica naturista, esta valida la opción. 

Para finalizar: Se hizo un estudio donde se comprueba que el champú de KETOCONAZOLE a nivel local disminuye la DHT, el cual podría usarse en conjunto con FINASTERIDE o SERENOA REPENS, en la Alopecia Androgénica  (referencia 60) 

 Les recuerdo que existe otra molécula similar al FINASTERIDE denominada DUTASTERIDE, la cual a diferencia de esta ultima, ademas de presentación en tabletas, viene en ampollas para infiltración local en el cuero cabelludo, mas NO HA SIDO APROBADA OFICIALMENTE para su uso en la Alopecia Androgénica, pero utilizado ampliamente por sus efectos beneficiosos demostrados en articulos publicados. 
 
El DUTASTERIDE conocido con el nombre comercial de AVODART fue aprobado por la FDA para su uso en la Hiperplasia Prostatica Benigna (HPB), al i¡gual que el FINASTERIDE, Pero como dijimos NO APROBADO PARA LA ALOPECIA ANDROGENICA. 
 
USO OFF LABEL: (Fuera de etiqueta): en la ALOPECIA ANDROGENICA:  
 
El DUTASTERIDE es usado ampliamente en esta condicion, aun NO ESTANDO APROBADO OFICALMENTE por LA FDA, para la Alopecia Androgenica, los medicos lo recetan y aplican localmente, basandose en la evidencia de estudios clinicos publicados que demuestran su efectividad. 

 En estas referencias los hechos... 

Saludos a todos !!!  

Dr. Jose Lapenta.
================================================================
REFERENCIAS BIBLIOGRÁFICAS / BIBLIOGRAPHICAL REFERENCES 
================================================================
DUTASTERIDE
================================================================ 
 ================================================================
SERENOA REPENS 
================================================================ 
1.) Testosterone metabolism in primary cultures of human prostate epithelial cells and fibroblasts. 
2.) Human prostatic steroid 5 alpha-reductase isoforms--a comparative study of selective inhibitors. 
3.) Effect of the lipidic lipidosterolic extract of Serenoa repens (Permixon) on the ionophore A23187-stimulated production of leukotriene B4 (LTB4) from human polymorphonuclear neutrophils. 
4.) Distribution study of radioactivity in rats after oral administration of the lipido/sterolic extract of Serenoa repens (Permixon) supplemented with [1-14C]-lauric acid, [1-14C]-oleic acid or [4-14C]-beta-sitosterol. 
5.) Biologically active acylglycerides from the berries of saw-palmetto (Serenoa repens). 
6.) Effect of Serenoa repens extract (Permixon) on estradiol/testosterone-induced experimental prostate enlargement in the rat. 
7.) Serenoa repens (Permixon). A review of its pharmacology and therapeutic efficacy in 
benign prostatic hyperplasia. 
8.) Comparison of finasteride (Proscar) and Serenoa repens (Permixon) in the inhibition of 5-alpha reductase in healthy male volunteers. 
9.) Comparative effects of alfuzosin versus Serenoa repens in the treatment of symptomatic benign prostatic hyperplasia. 
10.) Inhibition of the activity of 'basic' 5 alpha-reductase (type 1) detected in DU 145 cells and expressed in insect cells 
11.) Serenoa repens (Permixon): a 5alpha-reductase types I and II inhibitor-new evidence in a coculture model of BPH. 
12.) Inhibition of human sperm motility by specific herbs used in alternative medicine. 
13.) An alternative medicine study of herbal effects on the penetration of zona-free hamster oocytes and the integrity of sperm deoxyribonucleic acid. 
14.) Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. 
15.) Inhibitory effects of Serenoa repens on the kinetic of pig prostatic microsomal 5alpha-reductase activity. 
16.) Effects of long-term treatment with Serenoa repens (Permixon) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia. 
17.) Saw palmetto (Serenoa repens) in men with lower urinary tract symptoms: effects on urodynamic parameters and voiding symptoms. 
18.) Derivatization for electrospray ionization mass spectrometry. 3. Electrochemically ionizable derivatives. 
19.) Effect of the lipidosterolic extract of Serenoa repens (Permixon) and its major components on basic fibroblast growth factor-induced proliferation of cultures of human prostate biopsies. 
20.) Effects of the lipidosterolic extract of Serenoa repens (Permixon) on human prostatic cell lines. 
21.) Lack of effects of a lyposterolic extract of Serenoa repens on plasma levels of testosterone, follicle-stimulating hormone, and luteinizing hormone. 
22.) [Our experience with a hexane extract of Serenoa repens in the treatment of benign prostatic hypertrophy]. 
23.) Plant extracts in BPH. 
24.) [Pharmacological combinations in the treatment of benign prostatic hypertrophy]. 
25.) [Anti-inflammatory activity of sabal fruit extracts prepared with 
supercritical carbon dioxide. In vitro antagonists of cyclooxygenase and 5-lipoxygenase metabolism]. 
26.) [Symptomatic treatment of benign hypertrophy of the prostate. Comparative study of prazosin and serenoa repens]. 
27.) Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. 
28.) The effect of Permixon on androgen receptors. 
29.) Inhibition of androgen metabolism and binding by a liposterolic extract of "Serenoa repens B" in human foreskin fibroblasts. 
30.) Binding of Permixon, a new treatment for prostatic benign hyperplasia, to the cytosolic androgen receptor in the rat prostate. 
 =================================================================
FINASTERIDE 
================================================================= 
A.- Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial (2022).  

31.) [Clinical significance of testosterone and dihydrotestosterone metabolism in women]. 
32.) Finasteride: the first 5 alpha-reductase inhibitor. 
33.) A novel class of inhibitors for human steroid 5 alpha-reductase: phenoxybenzoic acid derivatives. I. 
34.) Management of androgenetic alopecia. 
35.) Continued improvement in pressure-flow parameters in men receiving finasteride for 2 years. Finasteride Urodynamics Study Group. 
36.) Economic analysis of finasteride: a model-based approach using data from the Proscar Long-Term Efficacy and Safety Study. 
37.) Comparison of finasteride and flutamide in the treatment of idiopathic hirsutism. 
38.) Validation of a population pharmacokinetic/pharmacodynamic model for 5alpha-reductase inhibitors. 
39.) Benign prostatic hyperplasia. A review of diagnostic and treatment options. Adv Nurse Pract 1999 Apr;7(4):31-6; quiz 37-8 
40.) Finasteride treatment for one year in 35 hirsute patients. 
41.) Impact of drug therapy on benign prostatic hyperplasia-specific quality of life. 
42.) Finasteride in the treatment of men with frontal male pattern hair loss. 
43.) Effect of finasteride and/or terazosin on serum PSA: results of VA Cooperative Study #359. 
44.) Androgenetic alopecia in men: the scale of the problem and prospects for treatment. 
45.) Inhibition of androgen synthesis in human testicular and prostatic microsomes and in male rats by novel steroidal compounds. 
46.) Finasteride: an update of its use in the management of symptomatic benign prostatic hyperplasia. 
47.) Efficacy of finasteride is maintained in patients with benign prostatic hyperplasia treated for 5 years. The North American Finasteride Study Group. 
48.) Long-term effects of finasteride on prostate tissue composition. 
49.) Treatment of male androgenetic alopecia with topical products containing Serenoa repens extract.
50.) Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study.
51.) Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study.
52.) A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia.
53.) Serenoa repens for benign prostatic hyperplasia.
54.) A bibliometric study of scientific literature in Scopus on botanicals for treatment of androgenetic alopecia.
55.) Serenoa Repens: Does It have Any Role in the Management of Androgenetic Alopecia?
56.) Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression.
57.) Persistent Sexual Dysfunction with Finasteride 1 mg Taken for Hair Loss.
58.) Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men with androgenetic alopecia.
59.) A novel finasteride 0.25% topical solution for androgenetic alopecia: pharmacokinetics and effects on plasma androgen levels in healthy male volunteers.
60.) Ketoconazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men.

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