The Erythema Annulare Centrifugum,
Looking for the origin, !!!
El Eritema Anular Centrifugo,
Buscando el origen. !
EDITORIAL ENGLISH
===================
Hello DERMAGIC friends, select this interesting title for a disease
described by DARIER in the year 1916 under the name of
Erithema Annular Centrifuge. Classified within the chapter of the GYRATE ERYTHEMAS, where two
(2) variants can be described: NOT ASSOCIATED WITH MALIGNANT diseases:
multiple causes. And another variant ASSOCIATED WITH INTERNAL MALIGNANCY
called
Paraneoplastic erythema annulare centrifugum eruption:( PEACE).
This disease or dermatological sign has several forms of presentation:
A deep and superficial form
that includes several subtypes: With vesiculation, papule, pruritus, and
desquamation. Lesions may or may not be migratory. It can occur in adults
and children. Many times it disappears after the cause is identified and
treated.
If we analyze with detail these bibliographical references we can reach the
following conclusions:
Clinical Entity:
Gyrate Erythema
1.) types:
a.) Deep.
B.) Superficial: Subtypes: Bullous, papulatum, and scaly with or
without pruritus.
2.) Etiology:
A hypersensitivity response to unrecognized antigens is
suspected.
3.) associations:
a.) Foods:
Tomatoes, blue cheese.
b.) Drugs:
Cimetidin, Antimalarials, Penicillin, Salicylates, Estrogen-Progesteron,
K vitamin, piroxicam, ampicillin and others
c.) LIVING Agents:
Molluscum Contagiosum, Epstein Barr virus, ascariasis, yersiniosis,
Streptococcal infections, Mycobateriun tuberculosis, Dermatophytes,
Cándida albicans, herpes zoster, borrelia burgdorferi.
d.) Colagen diseases:
Lupus, Sjogren syndrome, CREST syndrome.
e.) Bullous disease:
Bullous Pemphigoid, lineal IgA disease, pemphigus.
f.) Scaly disease:
Psoriasis
g.) Granulomatous diseases:
Sarcoidosis, Tuberculosis
h.) maLignant diseases:
Myeloma, Leukemia, Hodgkin's disease AND OTHERS.
i.) Endocrine Diseases:
Tiroiditis of Hashimoto, Grave's disease.
j.) Eosinophilic diseases:
Hypereosinophilic syndrome.
K.) Inflammatory bowel diseases:
Crohn's disease
I.) Miscelaneous:
Idiopatic, Familial
If we unify ALL of these data then we could consider it as a DERMATOLOGIC
SIGN associated to
non-malignant entities and
associated with MALIGNANT entities, being then considered another skin
marker of malignancy. So if you find this disease in your daily practice.
Think about this classification which will help better identify the cause
and request for the respective laboratory tests to truly recognize that
causes it.
In the 107 references the facts, in the attach the erythema annulare
centrifugum
Greetings to all !!.
Dr. José Lapenta.
EDITORIAL ESPANOL
===================
Hola Amigos DERMAGICOS, seleccione este interesante titulo para una
enfermedad descrita por DARIER en el año de 1.916 bajo el nombre de Eritema
Anular Centrifugo. Clasificado dentro del capitulo de los ERITEMAS
FIGURADOS, donde se pueden describir dos (2) variantes: NO ASOCIADO A
MALIGNIDAD: de múltiples causas. Y otra variante ASOCIADA A MALIGNIDAD
INTERNA denominada ERITEMA ANULAR CENTRIFUGO PARANEOPLASICO.
Esta enfermedad o SIGNO dermatológico tiene varias formas de presentación:
Una forma profunda y otra superficial
que incluye a su vez varios subtipos: Con vesiculación, pápulas,
prurito, y descamación. Las lesiones pueden ser o no migratorias. Puede
presentarse en adultos y niños. Muchas veces desaparece después de
identificada y tratada la causa.
Si analizamos con detalle estas referencias bibliográficas podemos sacar las
siguientes conclusiones:
Entidad Clínica: Eritema figurado
1.) Tipos:
1.A.) Profundo.
1.B.) Superficial:
subtipos: Vesiculoso papuloso y escamoso con o sin
prurito
2.) Etiologia:
Se sospecha de una respuesta de hipersensiblidad a antigenos
desconocidos.
3.) Asociaciones:
a.) Comidas:
Tomates, queso azul.
b.) Drogas:
Cimetidina, Antimalaricos, Penicilina, Salicilatos, Estrogenos,
Progesterona, K vitamin, piroxicam, ampicilina y otros
c.) Agentes vivos:
Molusco contagioso, Epstein barr. ascariasis, yersinia, Infecciones
estreptococcicas, Mycobateriun tuberculosis, Dermatofitos, Candida
albicans, herpes zoster, borrelia burgdorferi
d.) Enfermedades del colageno:
Lupus, Sindrome de Sjogren, CREST sindrome.
e.) Enfermedades ampollares:
Penfigoide ampollar, penfigo, Enfermedad por IgA lineal.
f.) Enfermedades escamosas:
Psoriasis.
g.) Enfermedades granulomatosas:
Sarcoidosis, Tuberculosis.
h.) Enfermedades malignas:
Mieloma multiple, Leucemia, Enfermedad de Hodgkin y otros.
i.) Enfermedades endocrinas:
Tiroiditis de Hashimoto, enfermedad de Graves.
j.) Enfermedades eosinofilicas:
Sindrome hipereosinofilico.
k.) Enfermedades intestinal inflamatoria:
Enfermedad de Crohn
k.) Miscelaneos:
Idiopatico, familiar.
Si unificamos TODOS estos datos entonces lo podríamos considerar como SIGNO
DERMATOLOGICO asociado a entidades NO MALIGNAS Y asociado a entidades
MALIGNAS, siendo entonces considerado otro marcador cutáneo de malignidad.
De modo que si les presenta esta enfermedad en su practica diaria. Piensen
en esta clasificación la cual les ayudara a identificar mejor la causa y
pedir los respectivos exámenes de laboratorio para reconocer verdaderamente
que lo provoco.
En las referencias los hechos ...
Saludos a todos.
Dr. José Lapenta R.
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REFERENCIAS BIBLIOGRAFICAS /
BIBLIOGRAPHICAL REFERENCES
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1.) Gyrate erythema.
2.) [Erythema annulare centrifugum Darier].
3.) Recurrent acute appendicitis with erythema annulare centrifugum.
4.) Erythema annulare centrifugum, angio-oedema in lupus vulgaris.
5.) Erythema annulare centrifugum. A case due to tuberculosis.
6.) [Erythema annulare centrifugum of the legs symptomatic of prostate
adenocarcinoma; a specific paraneoplastic syndrome]?
7.) Erythema annulare centrifugum and Hodgkin's disease: association with
disease activity.
8.) On erythema annulare centrifugum-type of psoriasis.
9.) Annular psoriasiform eruption with lymphocytic
infiltration of the epidermis: a variant of acute psoriasis?
10.) Psoriasis: odd varieties in the adult.
11.) [Localized form of psoriasis of the erythema annulare centrifugum type
with pustulation]
12.) [Psoriasis and pustular psoriasis of the erythema annulare centrifugum
type (3 cases)].
13.) Erythema annulare centrifugum induced by molluscum contagiosum.
14.) Erythema annulare centrifugum and molluscum contagiosum.
15.) [Hypereosinophilic syndrome. Cutaneous picture of "erythema annulare
centrifugum"--comparison with ultrastructural study].
16.) [Hypereosinophilic syndrome. Centrifugal annular erythema as an initial
manifestation].
17.) Erythema annulare centrifugum as the presenting sign of the
hypereosinophilic syndrome: observations on therapy.
18.) [Erythema annulare centrifugum as a symptom in acute myeloid
leukemia].
19.) Annular erythemas in infants associated with autoimmune disorders in
their mothers. Report on three cases.
20.) Ampicillin induced erythema annulare centrifugum.
21.) [Specific leukemic infiltration with the appearance of erythema
annulare centrifugum (Darier) in chronic lymphadenosis].
22.) Unusual cutaneous associations of a malignant carcinoid tumour of the
bronchus--erythema annulare centrifugum and white banding of the toe
nails.
23.) [The bullous variant of erythema annulare centrifugum Darier in Candida
albicans infections].
24.) [Migrant eruptions in lupus erythematosus. Apropos of a case of lupus
erythematosis gyratus repens].
25.) Erythema annulare centrifugum coincident with Epstein-Barr virus
infection in an infant.
26.) Erythema annulare centrifugum and relapsing polychondritis.
27.) Vulvar disease in children: a clinical audit of 130 cases.
28.) Amitriptyline-induced erythema annulare centrifugum.
29.) Drugs causing fixed eruptions: a study of 450 cases.
30.) Erythema annulare centrifugum in a patient with polyglandular
autoimmune disease type 1.
31.) Recurrent ringed lesion of the sole: erythema annulare centrifugum.
32.) Erythema annulare centrifugum associated with pregnancy.
33.) [Annular erythema in childhood--a new eosinophilic dermatosis].
34.) Erythema annulare centrifugum and intestinal Candida albicans
infection--coincidence or connection?
35.) Dermacase. Erythema annulare centrifugum.
36.) Psoriasis: changing clinical patterns.
37.) Erythema annulare centrifugum and Escherichia coli urinary
infection.
38.) Sarcoidosis presenting as erythema annulare centrifugum.
39.) [Recurrent annular erythema--cutaneous manifestation of Sjogren
syndrome with anti SS-A (Ro) and anti SS-B (La) antibodies].
40.) Non-small-cell lung cancer with multiple paraneoplastic syndromes.
41.) [Darier's erythema annulare centrifugum of neonatal onset with a 15
years' follow-up. Efficacy of interferon and role of cytokines].
42.) Erythema annulare centrifugum unresponsive to immunosuppressive
therapy.
43.) Annular vasculitis associated with pregnancy.
44.) Inflammatory carcinoma masquerading as erythema annulare
centrifugum.
45.) [Darier's erythema annulare centrifugum and primary Vaquez
polycythemia]
46.) Recurrent annular erythema with anti-SSA/Ro and anti-SSB/La antibodies
localized on palms and fingers in an elderly man.
47.) Clinical and immunological analysis of annular erythema associated with
Sjogren syndrome.
48.) Clinical, serological and immunogenetic features of Japanese
anti-Ro/SS-A-positive patients with annular erythema.
49.) Persistent annular erythema of infancy.
50.) HLA antigens in anti-Ro(SS-A)-positive patients with recurrent annular
erythema.
51.) Urticated annular erythema: a new manifestation of Sjogren's
syndrome.
52.) Recurrent annular erythema associated with anti-SS-
53.) Erythema annulare centrifugum associated with gold sodium thiomalate
therapy.
54.) Annular erythema. A comparative study of Sjogren syndrome with subacute
cutaneous lupus erythematosus.
55.) Annular erythema associated with Sjogren's syndrome: a variant of
systemic lupus erythematosus [see comments]
56.) Lymphocyte response to staphylococcal enterotoxin B in patients with
annular erythema associated with Sjogren syndrome.
57.) ICAM-1 and LFA-1 expressions in the lesional skin of annular erythema
associated with Sjogren syndrome.
58.) Annular erythema associated with primary Sjogren syndrome: analysis of
T cell subsets in cutaneous infiltrates [see comments]
59.) Annular erythema in identical twins.
60.) Annular erythema: a possible association with primary Sjogren's
syndrome.
61.) Neonatal lupus syndrome and microtubular structure.
62.) Erythema annulare of infancy.
63.) An annular erythema of infancy.
64.)Reactive annular erythema after intramuscular vitamin K.
65.) Annular erythema of infancy.
66.) [Erythema annulare centrifugum revealing linear IgA dermatitis of
childhood]
67.) Erythema annulare centrifugum: an unusual case due to
hydroxychloroquine sulfate.
68.) 'Persistent' annular erythema of infancy.
69.) Erythema annulare centrifugum associated with ascariasis.
70.) Annular erythema of infancy.
71.) Annular erythema as an unusual manifestation of chronic disseminated
lupus erythematosus.
72.) Multiple annular erythema [letter]
73.) Reactive erythemas: erythema annulare centrifugum and erythema gyratum
repens.
74.) [Squamous erythema annulare centrifugum]
75.) Annular erythema associated with Sjogren's syndrome [letter;
comment]
76.) An intensive care unit nurse with a recurring annular lesion. Erythema
annulare centrifugum (EAC).
77.) Erythema annular centrifugum in Q fever.
78.) Erythema annulare centrifugum caused by hydrochlorothiazide-induced
interstitial nephritis.
79.) [Erythema annulare centrifugum disclosing hyperthyroidism]
80.) Eruption resembling erythema annulare centrifugum due to thiacetazone
[letter]
81.) [Erythema annulare centrifugum caused by aldactone]
82.) [On the physiopathology of erythema annulare centrifugum]
83.) Erythema annulare centrifugum associated with liver disease.
84.) [Erythema annulare centrifugum and Hashimoto's thyroiditis]
85.) Erythema annulare centrifugum associated with piroxicam [letter]
86.) Annular erythema with histologic features of leukocytoclastic
vasculitis in ulcerative colitis.
87.) Erythema annulare centrifugum and malignant histiocytosis--report of a
case.
88.) Pityrosporum infection in an infant with lesions resembling erythema
annulare centrifugum.
89.) Erythema annulare centrifugum: a review of 24 cases with special
reference to its association with underlying disease.
90.) [Pemphigoid with recurrence of the centrifugal-development bullous
annular erythema type]
91.) [Bullous pemphigoid with an erythema annulare centrifugum appearance
and a bullous border]
92.) [Erythema annulare centrifugum and antinuclear antibodies]
93.) Erythema annulare centrifugum. A case due to tuberculosis.
94.) Erythema annulare centrifugum and Graves' disease [letter]
95.) Cimetidine-induced erythema annulare centrifugum: no cross-sensitivity
with ranitidine.
96.) [Nosologic problems posed by a case of desquamative erythema annulare
centrifugum]].
97.) [Erythema annulare centrifugum Darier as a reaction form in diseases of
the reticulo-histiocyte system].
98.) [Erythema annulare centrifugum of Darier, squamous variety].
99.) [Erythema annulare centrifugum with loco-regional recurrences during
the course of tuberculous coxitis. Focal reaction to tuberculin].
100.) The Gyrate Erythemas
101.) Erythema annulare centrifugum: case due to hypersensivite to blue
cheese penicillium.
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1.) Gyrate erythema.
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Dermatol Clin 1985 Jan;3(1):129-39
White JW Jr
The gyrate erythemas consist of a nonspecific group (often called erythema
annulare centrifugum) for which the cause is usually unknown, and three
specific types (erythema marginatum rheumaticum, erythema chronicum migrans
[Lyme disease], and erythema gyratum repens). The first specific type,
erythema marginatum rheumaticum, has become extremely rare with the decline
of its associated disease, rheumatic fever. The second specific type,
erythema chronicum migrans, is caused by a spirochete transmitted by the I.
ricinus complex of ticks. The third specific type, erythema gyratum repens,
is uncommon, morphologically distinctive, and an indicator of serious
disease, usually internal malignancy, in almost every instance.
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2.) [Erythema annulare centrifugum Darier].
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Hautarzt 1979 Dec;30(12):673-5 Related Articles, Books, LinkOut
[Article in German]
Baurle G
The symptoms of erythema anulare centrifugum Darier are demonstrated in a
60-year-old patient. A paraneoplastic syndrome was sufficiently ruled out.
The skin lesions quickly healed during treatment of an urinary tract
infection.
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3.) Recurrent acute appendicitis with erythema annulare centrifugum.
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Arch Intern Med 1984 Oct;144(10):2090-2 Related Articles, Books, LinkOut
Sack DM, Carle G, Shama SK
Erythema annulare centrifugum (EAC), a chronic figurate eruption, occurred
in a 28-year-old male physician several months following the onset of
recurrent abdominal pain. Two months after the manifestation of EAC, another
episode of abdominal pain culminated in appendectomy for perforated
appendicitis. During his convalescence, the skin lesions faded and did not
reappear. We propose that recurrent appendiceal inflammation caused both the
episodic pain and the skin eruptions. Additionally EAC may be a sign of
chronic infection, internal malignancy, or food allergy. Although truly
chronic appendicitis is a disputed entity, recurrent, spontaneously
resolving episodes of appendicitis occasionally do precede surgical
appendicitis. The presence of EAC in a patient having recurrent abdominal
pain should discourage a precipitant diagnosis of functional illness and
prompt further investigation.
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4.) Erythema annulare centrifugum, angio-oedema in lupus vulgaris.
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JPMA J Pak Med Assoc 1984 Sep;34(9):276-9
Shabbir SG, Hassan M, Kazmi SA, Jahangir M
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5.) Erythema annulare centrifugum. A case due to tuberculosis.
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Int J Dermatol 1982 Nov;21(9):538-9 Related Articles, Books, LinkOut
Burkhart CG
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6.) [Erythema annulare centrifugum of the legs symptomatic of prostate
adenocarcinoma; a specific paraneoplastic syndrome]?
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Ann Dermatol Venereol 1979 Oct;106(10):789-92 Related Articles, Books,
LinkOut
[Article in French]
Dupre A, Carrere A, Bonafe JL, Viraben R, Christol B, Lassere J
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7.) Erythema annulare centrifugum and Hodgkin's disease: association with
disease activity.
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Arch Intern Med 1979 Apr;139(4):486-7 Related Articles, Books, LinkOut
Leimert JT, Corder MP, Skibba CA, Gingrich RD
The skin lesions of erythema annulare centrifugum developed in a 58-year-old
woman who had Hodgkin's disease. Response of the neoplasm to vinblastine
sulfate was accompanied by disappearance of the skin lesions. When therapy
was discontinued, both disorders recurred, and both responded to
reinstitution of vinblastine therapy. To our knowledge, this case is the
first reported association of erythema annulare centrifugum and Hodgkin's
disease. The cutaneous manifestation in this patient were a nonneoplastic
concomitant of her neoplastic disorder.
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8.) On erythema annulare centrifugum-type of psoriasis.
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Acta Derm Venereol Suppl (Stockh) 1979;59
Rajka G, Thune PO
A case of EAC type psoriasis is reported. Routine and immunologic
investigations were negative. HLA-B8 was found by typing. Some therapeutic
benefit was achieved by combination of retinoid (Ro-10-9359) plus PUVA.
According to a review of the literature half of the cases are unconnected to
classical psoriasis, whereas the other half is connected and mostly of
(periodic) pustular character. The necessity of clinical research in this
intermediate type between psoriasis vulgaris and pustulosa is emphasized.
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9.) Annular psoriasiform eruption with lymphocytic
infiltration of the epidermis: a variant of acute psoriasis?
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SO - Dermatology 1992;185(2):156-9
AU - Terunuma A; Takahashi K; Sakakibara A; Aiba S; Tagami H
PT - JOURNAL ARTICLE
AB - Disseminated annular psoriasiform lesions developed over a period of 2
months in a 48-year-old man with no preceding psoriatic history of drug
intake, being accompanied by general dullness and arthralgia. Etretinate was
effective for both skin eruption and arthralgia; only the latter recurred on
its cessation 5 months later. However, histologic features examined by
serial sections totally lacked those of pustular psoriasis; there were no
neutrophils in the epidermis where massive T lymphocyte infiltration existed
instead, in a fashion similar to that of early psoriatic lesions. We
differentiated this peculiar annular psoriasiform eruption from the annular
erythematous lesions noted in pityriasis rosea, erythema annulare
centrifugum, subacute cutaneous lupus erythematosus, annular erythema
associated with Sjogren's syndrome and erythema chronicum migrans. It is our
speculation that this dermatosis represents a variant of acute psoriasis,
rather than annular pustular psoriasis. The histopathologic and
immunohistologic findings suggest ongoing cellular immune responses in these
lesions where some unknown inhibitory mechanisms might be operative against
further production of neutrophil chemotactic factors that usually takes
place in psoriatic lesions.
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10.) Psoriasis: odd varieties in the adult.
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Acta Derm Venereol Suppl (Stockh) 1979;87:90-4
Kerl H, Pachinger W
Occasionally we observe particular varieties of psoriasis and in rare cases
transitional features with other diseases, which pose problems concerning
the differential diagnosis and the nosological classification. This
communication deals with the following clinical and histological aspects of
psoriasis: 1) Sebopsoriasis. Relationship of psoriasis to pityriasis rubra
pilaris. 2) Erythema annulare centrifugum type of psoriasis. 3) Is
subcorneal pustular dermatosis an expression of pustular psoriasis? 4)
Salient histopathological criteria for the diagnosis of the different
atypical forms of psoriasis. 5) Presentation of an unusal case with striated
and retiform verrucous psoriasis-like eruptions, which show a relationship
to parakeratosis variegata.
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11.) [Localized form of psoriasis of the erythema annulare centrifugum type
with pustulation]
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SO - Hautarzt 1984 Jan;35(1):53-5
AU - Zala L; Hunziker T
PT - JOURNAL ARTICLE
AB - We report two cases of localized psoriasis of the erythema anulare
centrifugum-type with pustulation. Problems of nosological classification
and histological differentiation are discussed.
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12.) [Psoriasis and pustular psoriasis of the erythema annulare centrifugum
type (3 cases)].
Bull Soc Fr Dermatol Syphiligr 1966 Jul-Aug;73(4):356-8
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[Article in French]
Degos R, Civatte J, Arrouy M
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13.) Erythema annulare centrifugum induced by molluscum contagiosum.
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Br J Dermatol 1993 Nov;129(5):646-7
Furue M, Akasu R, Ohtake N, Tamaki K
Publication Types:
Letter
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14.) Erythema annulare centrifugum and molluscum contagiosum.
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Arch Dermatol 1978 Dec;114(12):1853
Vasily DB, Bhatia SG
Publication Types:
Letter
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15.) [Hypereosinophilic syndrome. Cutaneous picture of "erythema annulare
centrifugum"--comparison with ultrastructural study].
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Med Cutan Ibero Lat Am 1988;16(4):299-304
[Article in Portugese]
Calux MJ, Valente NY, Pires MC, Albertoni Neto DR
Hospital do Servidor Publico Estadual de Sao Paulo.
The authors present the third case in the literature of hypereosinophilic
syndrome with "erythema annulare centrifugum" like lesions. Cutaneous
manifestations were the first sign of the disease. Laboratory investigation
including ultrastructural study of cutaneous lesions. This kind of
investigation has been done before in only one instance. Clinical and
laboratory features of the case are fully discussed taking into account
literature findings.
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16.) [Hypereosinophilic syndrome. Centrifugal annular erythema as an initial
manifestation].
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Med Cutan Ibero Lat Am 1978;6(5-6):267-72
[Article in Spanish]
Woscoff A, Dancziger E, Zamparo DI
Several closely related conditions make up the idopathic hypereosinophilic
syndrome. This syndrome is characterized by persistent and prolonged
eosinophilia. The most frequent lesions are in the hematologic, neurologic
and gastrointestinal systems. A case is reported in which the initial
complaint was an erythema annulare centrifugum.
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17.) Erythema annulare centrifugum as the presenting sign of the
hypereosinophilic syndrome: observations on therapy.
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SO - Cutis 1985 Jan;35(1):53-5
AU - Shelley WB; Shelley ED
PT - JOURNAL ARTICLE
AB - A 79-year-old man with severe generalized pruritus and erythema
annulare centrifugum as manifestations of his idiopathic hypereosinophilic
syndrome slowly responded to long-term therapy with ketoconazole and
dapsone. The skin lesions cleared within one month but the pruritus and
eosinophilia required seven full months of therapy.
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18.) [Erythema annulare centrifugum as a symptom in acute myeloid
leukemia].
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Z Hautkr 1977 Feb 1;52(3):77-80
[Article in German]
Bonniger F, Happle R
Erythema annulare centrifugum occurred in a 68 year-old women suffering from
acute myeloid leukemia. A "paraneoplastic" origin of the skin disease was
most probable in this case.
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19.) Annular erythemas in infants associated with autoimmune disorders in
their mothers. Report on three cases.
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Dermatologica 1977;154(2):115-27
Hammar H, Ronnerfalt L
Three infant boys with a centrifugal annular erythema mainly consistent with
erythema annulare centrifugum, developing a few weeks after birth, are
described. The lesions disappeared before the age of 6 months, without
atrophy, and during this period the infants were otherwise healthy. This
group is considered to belong to one of three types of reactivity in infants
associated with or expressed as a connective tissue disease, especially
lupus erythematosus, in the mother and child or in either. In type 1, signs
and symptoms of systemic lupus erythematosus are or will be present in the
mother and the child displays discoid lupus erythematosus lesions at birth
or soon after. In type 2, the mother has the same signs and symptoms as in
type 1 but the child develops a centrifugal annular erythema 3-6 weeks after
birth. In type 3, discoid lupus erythematosus is present at an early stage
in the infant, while the mother is healthy. This type may represent an early
onset of lupus erythematosus in the infants.
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20.) Ampicillin induced erythema annulare centrifugum.
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J Indian Med Assoc 1975 Dec 1;65(11):307-8
Gupta HL, Sapra SM
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21.) [Specific leukemic infiltration with the appearance of erythema
annulare centrifugum (Darier) in chronic lymphadenosis].
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Hautkr 1975 Nov 15;50(22):930-7
[Article in German]
Diem E
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22.) Unusual cutaneous associations of a malignant carcinoid tumour of the
bronchus--erythema annulare centrifugum and white banding of the toe
nails.
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Br J Dermatol 1975 Sep;93(3):341-5
Everall JD, Dowd PM, Ardalan B
The case history of a patient who presented with erythema annulare
centrifugum and white banding of the toe nails is recorded. On investigation
for an underlying malignancy the patient was found to have an opacity in the
lower lobe of the right lung. Subsequently lobectomy was performed and
histology of the operative specimen revealed a malignant carcinoid tumour of
the bronchus.
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23.) [The bullous variant of erythema annulare centrifugum Darier in Candida
albicans infections].
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Hautarzt 1975 Sep;26(9):466-70
[Article in German]
Kind R
A 15-year old male patient with Down-Syndrome suffering from a unusual
vesicular type of erythema annular centrifugum Darier and a concurrent
intestinal infection with candida albicans is described. Histology,
immunhistological assay, and clinical observation allowed to differentiate
Erythema annulare centrifugum from erythema exsudativum multiforme as well
as dermatitis herpetiformis. On the basis of immunological findings and the
clinical course, a hypersensitivity to candida albicans like a so-called
"id-reaction" is assumed to be the main etiological factor in this case.
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24.) [Migrant eruptions in lupus erythematosus. Apropos of a case of lupus
erythematosis gyratus repens].
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Ann Dermatol Syphiligr (Paris) 1975;102(5-6):481-9
[Article in French]
Hewitt J, Benveniste M, Kaufmann P, Lessana-Leibowitch M
Rare cases of migrant circinated eruptions occurring during the course of
lupus erythematosus have been published so far. They have been classified in
two categories: 1) supposed toxicodermias due to antimalarials; 2) real
cases of erythema annulare centrifugum, mostly inaugurating the L. E. In an
exceptional case, a migrating eruption looking like an erythema annulare
with a complicated pattern on the trunk, neck and limbs, took place between
two rashes of typical L.E. The exact nature of this eruption, clinically and
histologically atypical, and its relation with the L.E. itself, have been
discussed.
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25.) Erythema annulare centrifugum coincident with Epstein-Barr virus
infection in an infant.
============================================================
Acta Paediatr Scand 1974 Sep;63(5):788-92
Hammar H
============================================================
============================================================
26.) Erythema annulare centrifugum and relapsing polychondritis.
============================================================
Ann Dermatol Venereol 2000 Aug-Sep;127(8-9):735-9
Ingen-Housz S, Venutolo E, Pinquier L, Cavelier-Balloy B, Dubertret L,
Flageul B
Service de Dermatologie 1, Hopital Saint-Louis, 1, avenue Claude-Vellefaux,
75475 Paris Cedex 10.
[Medline record in process]
BACKGROUND: Relapsing polychondritis is a rare systemic disease. Skin
involvement occurs in 20 to 50 % of cases. Cutaneous signs are most often
related to a leukocytoclastic vasculitis. Association of relapsing
polychondritis with neutrophilic dermatosis have also been reported. We
report the first case of an erythema annulare centrifugum-like dermatosis
associated with relapsing polychondritis, with a two years delay between
both conditions. CASE REPORT: A 74 year-old man was seen for
papulo-erythematous centrifugal annular lesions that appeared 18 months
earlier in a context of bad general conditions. Biological tests were
normal. Several skin biopsies were performed, showing at the beginning
features of drug reaction and then of lupus-lichen. Treatment with
hydroxychloroquine, topical corticosteroids, dapsone and thalidomide were
unsuccessful. In the following months, the patient developed fever and
relapsing bronchitis. Suddenly, a chondritis of the ears appeared, leading
to the diagnosis of relapsing polychondritis. All the cutaneous, chondritic
and respiratory signs disappeared with oral steroid therapy. Two years after
the diagnosis of relapsing polychondritis the patient developed refractory
anemia. DISCUSSION: Cutaneous signs of relapsing polychondritis are frequent
and may occur several months or years before the chondritis. They are
polymorphous, but to the best of our knowledge, a clinical aspect of
erythema annulare centrifugum has never been described. Our observation
recalls the sometimes long delay between the cutaneous and the chondritic
signs of relapsing polychondritis and the high frequency of dysmyelopoiesis
in relapsing polychondritis with cutaneous involvement.
============================================================
27.) Vulvar disease in children: a clinical audit of 130 cases.
============================================================
Pediatr Dermatol 2000 Jan-Feb;17(1):1-6
Fischer G, Rogers M
Department of Dermatology, Royal Alexandra Hospital for Children, Westmead,
Australia.
We evaluated 130 prepubertal girls presenting with a vulvar complaint to
determine the spectrum and frequency of conditions seen in this age group.
Of the patients, 41 (33%) had atopic or irritant dermatitis, 23 (18%) had
lichen sclerosus, 21 (17%) had psoriasis, 15 (12%) had vulvar lesions, most
often hemangiomas and nevi, and 13 (10%) had streptococcal vulvovaginitis.
Diagnoses less frequently seen were staphylococcal folliculitis (four
patients), labial fusion (three patients), genital warts (two patients),
molluscum contagiosum of the vulva only (one patient), vulvar bullous
pemphigoid (two patients), scabies nodules (one patient), erythema annulare
centrifugum (one patient), tinea (two patients), and vitiligo (one patient).
We also encountered vulvar presentations of systemic diseases (varicella,
staphylococcal scalded skin syndrome, and Henoch-Schonlein purpura, all one
patient each). We did not see candidal vulvovaginitis in this age group nor
did we encounter bacterial infection with pathogens other than
Staphylococcus aureus and S. pyogenes.
============================================================
28.) Amitriptyline-induced erythema annulare centrifugum.
============================================================
Cutis 1999 Jan;63(1):35-6
Garcia-Doval I, Peteiro C, Toribio J
Department of Dermatology, General Hospital of Galicia, Faculty of Medicine,
Santiago de Compostela, Spain.
A case of amitriptyline-induced superficial erythema annulare centrifugum
(EAC) is reported. Its singular characteristics are prominent epidermal
manifestations, with clinical and histologic vesiculation, associated with
vacuolar degeneration at the dermoepidermal junction; numerous arciform
lesions, accompanied by diffuse erythema on rechallenge; quick change, more
rapid than that usually described for EAC; and a short course, in contrast
with the usual chronic evolution of EAC. To our knowledge, this is the first
reported case of EAC associated with amitriptyline intake.
============================================================
29.) Drugs causing fixed eruptions: a study of 450 cases.
============================================================
Int J Dermatol 1998 Nov;37(11):833-8
Mahboob A, Haroon TS
Department of Dermatology, King Edward Medical College/Mayo Hospital,
Lahore, Pakistan.
BACKGROUND: Drug eruptions are among the most common cutaneous disorders
encountered by the dermatologist. Some drug eruptions, although trivial, may
cause cosmetic embarrassment and fixed drug eruption (FDE) is one of them.
The diagnostic hallmark is its recurrence at previously affected sites.
OBJECTIVE: We evaluated 450 FDE patients to determine the causative drugs.
RESULTS: The ratio of men to women was 1:1.1. The main presentation of FDE
was circular hyperpigmented lesion. Less commonly FDE presented as:
nonpigmenting erythema, urticaria, dermatitis, periorbital or generalized
hypermelanosis. Occasionally FDE mimicked lichen planus, erythema
multiforme, Stevens-Johnson syndrome, paronychia, cheilitis, psoriasis,
housewife's dermatitis, melasma, lichen planus actinicus, discoid lupus
erythematosus, erythema annulare centrifugum, pemphigus vulgaris,
chilblains, pityriasis rosea and vulval or perianal hypermelanosis.
Cotrimoxazole was the most common cause of FDE. Other drugs incriminated
were tetracycline, metamizole, phenylbutazone, paracetamol, acetylsalicylic
acid, mefenamic acid, metronidazole, tinidazole, chlormezanone, amoxycillin,
ampicillin, erythromycin, belladonna, griseofulvin, phenobarbitone,
diclofenac sodium, indomethacin, ibuprofen, diflunisal, pyrantel pamoate,
clindamycin, allopurinol, orphenadrine, and albendazole. CONCLUSIONS:
Cotrimoxazole was the most common cause of FDE, whereas FDE with diclofenac
sodium, pyrantel pamoate, clindamycin, and albendazole were reported for the
first time. FDE may have multiform presentations.
============================================================
30.) Erythema annulare centrifugum in a patient with polyglandular
autoimmune disease type 1.
============================================================
Cutis 1998 Nov;62(5):231-2
Garty B
Kipper Institute of Pediatric Immunology, Department of Pediatrics A,
Schneider Children's Medical Center of Israel, Petah Tiqva.
The dermatologic disorders in polyglandular autoimmune disease (PGAD) type 1
(previously called chronic mucocutaneous candidiasis) are nail dystrophy,
vitiligo, and alopecia. A patient with PGAD and erythema annulare
centrifugum (EAC) is presented. This association has not been reported
previously. EAC may be related to occult or low-grade Candida infection in
PGAD.
============================================================
31.) Recurrent ringed lesion of the sole: erythema annulare centrifugum.
============================================================
J Am Podiatr Med Assoc 1998 Mar;88(3):144-5
Lemont H, Garber R, Ortenzi J
Publication Types:
Letter
============================================================
============================================================
32.) Erythema annulare centrifugum associated with pregnancy.
============================================================
Acta Derm Venereol 1998 May;78(3):237-8
Choonhakarn C, Seramethakun P
Publication Types:
Letter
============================================================
============================================================
33.) [Annular erythema in childhood--a new eosinophilic dermatosis].
============================================================
Hautarzt 1998 Feb;49(2):131-4
[Article in German]
Kunz M, Hamm K, Brocker EB, Hamm H
Klinik und Poliklinik fur Haut- und Geschlechtskrankheiten, Universitat
Wurzburg.
Annular erythema of infancy is a rare and little-known entity. Since its
initial description by Peterson and Jarratt in 1981 only 4 further cases
have been reported. We present the first case in the German literature. A
4-year-old boy developed non-itching erythematous papules on the trunk which
evolved into annular and gyrate erythemas within weeks. The condition showed
a relapsing course with disease-free intervals of several months duration.
There were no general complaints. Laboratory investigations including
detailed serological tests for infectious diseases were normal.
Histopathology showed a striking eosinophilic inflammatory infiltrate
predominantly in perivascular areas, without peripheral blood eosinophilia.
The clinical differential diagnosis of annular erythema of infancy includes
erythema annulare centrifugum, while microscopically one must exclude
eosinophilic cellulitis (Wells' syndrome). The etiology is unknown and there
is no effective therapy. In our case, as well as in all previously published
cases, the disease resolved spontaneously. Therefore, it may be considered
benign and self-limited.
============================================================
34.) Erythema annulare centrifugum and intestinal Candida albicans
infection--coincidence or connection?
============================================================
Acta Derm Venereol 1997 Jan;77(1):93-4
Schmid MH, Wollenberg A, Sander CA, Bieber T
Publication Types:
Letter
============================================================
============================================================
35.) Dermacase. Erythema annulare centrifugum.
============================================================
Can Fam Physician 1996 Nov;42:2148, 2151 Related Articles, Books, LinkOut
Enta T
University of Calgary.
============================================================
============================================================
36.) Psoriasis: changing clinical patterns.
============================================================
Australas J Dermatol 1996 May;37 Suppl 1:S27-9 Related Articles, Books,
LinkOut
Rotstein H
Department of Dermatology, St Vincent's Hospital, Melbourne, Victoria,
Australia.
Although psoriasis has been recognized at least since Biblical times new
forms, associations and influences continue to be described in the twentieth
century. New forms include the rupioid erythema annulare centrifugum-like
and follicular patterns. Associations with vitiligo bullous pemphigoid and
lupus erythematosus have been recently described. Endoscopic surgery has
increased para umbilical psoriasis while Sun Smart campaign have reduced
photo-aggravated psoriasis. Infections such as paediatric perianal
streptococcal cellulitis and drugs including angiotensin converting enzyme
inhibitors and cytokines exacerbate psoriasis.
============================================================
37.) Erythema annulare centrifugum and Escherichia coli urinary
infection.
============================================================
Lancet 1996 Mar 30;347(9005):897-8
Borbujo J, de Miguel C, Lopez A, de Lucas R, Casado M
Publication Types:
Letter
============================================================
============================================================
38.) Sarcoidosis presenting as erythema annulare centrifugum.
============================================================
Clin Exp Dermatol 1995 Nov;20(6):502-3
Altomare GF, Capella GL, Frigerio E
Instituto di Dermatologia, Ospedale Maggiore IRCCS, Universita degli Studi
di Milano, Italy.
Erythema annulare centrifugum (EAC), a disease belonging to the poorly
characterized category of 'figurate erythemas', has been associated with a
variety of conditions, such as connective tissue diseases, infections,
neoplasms and drug reactions. Here we report a case of EAC associated with
sarcoidosis, the first case in the literature to our knowledge. EAC was the
sole sign of the granulomatous disease process, which was diagnosed by means
of appropriate investigations only after the patient reported the sudden
resolution of a long-standing sensitization to perfumes and parabens.
Steroid treatment for sarcoidosis improved the patient's condition, and
restored the allergic response to these substances.
============================================================
39.) [Recurrent annular erythema--cutaneous manifestation of Sjogren
syndrome with anti SS-A (Ro) and anti SS-B (La) antibodies].
============================================================
Nippon Rinsho 1995 Oct;53(10):2557-62
[Article in Japanese]
Usuda T
Division of Dermatology, Social Insurance Chukyo Hospital.
Eight cases of Sjogren syndrome (SjS) with anti-SS-A and anti-SS-B
antibodies are reported. They developed erythema annulare centrifugum-like
annular erythema which mainly appeared on the face. Laboratory tests showed
similar serologic changes. RA factor, speckled type antinuclear antibody,
anti SS-A & SS-B antibodies (DID & ELISA) were observed but
complements and anti-double stranded DNA antibodies were not detected. In
spite of mild sicca symptoms, sialogram, lip biopsy, Shirmer test and Rose
Bengal staining showed typical changes of SjS. It is considered that the
recurrent annular erythema is a specific skin manifestation of SjS with anti
SS-A/SS-B antibodies.
============================================================
40.) Non-small-cell lung cancer with multiple paraneoplastic syndromes.
============================================================
Eur Respir J 1995 Jul;8(7):1231-4
Monsieur I, Meysman M, Noppen M, de Greve J, Delhove O, Velckeniers B,
Jacobvitz D, Vincken W
Dept of Internal Medicine, Academic Hospital, University of Brussels
(AZ-VUB), Belgium.
We describe the case of a patient with multiple paraneoplastic syndromes,
six in total, associated with a non-small-cell cancer of the lung. In this
single patient we found hypertrophic pulmonary osteoarthropathy,
hyperkeratosis of palms and soles, erythema annulare centrifugum, syndrome
of inappropriate secretion of antidiuretic hormone (SIADH), and ectopic
andrenocorticotrophic hormone (ACTH) and calcitonin production.
============================================================
41.) [Darier's erythema annulare centrifugum of neonatal onset with a 15
years' follow-up. Efficacy of interferon and role of cytokines].
============================================================
Ann Dermatol Venereol 1995;122(6-7):422-6
[Article in French]
Guillet MH, Dorval JC, Larregue M, Guillet G
Service de Dermatologie, CHU Brest
INTRODUCTION. Darier's erythema annulare centrifugum (EAC) is a disease of
unknown etiology. Some observations of EAC in infancy suggest a better
prognosis for early EA. The observations presented herein gives different
information regarding prognosis and pathogenesis. OBSERVATION. A child
presents with typical lesions of EAC from early infancy up to the age of 15
years. Laboratory data are normal. Similar lesions were locally reproduced
by intradermal injection by candidine but antifungal drugs were
unsuccessful. Many antiinflammatory treatments failed to improve the
disease. Because of the improvement during hyperthermic episodes, a
treatment by subcutaneous interferon alpha (2 millions U 3 times a week) was
given for six months with a dramatic success (with seric increase of TNF
alpha and IL2) DISCUSSION. The long term duration of EAC suggests that EA of
infancy may represent the early beginning of Darier's EAC. The efficacy of
interferon suggests that cytokines are involved in the pathogenesis of
EAC.
============================================================
42.) Erythema annulare centrifugum unresponsive to immunosuppressive
therapy.
============================================================
Br J Dermatol 1994 Oct;131(4):587
Phillips WG, Ramsay ID, Breathnach SM
Publication Types:
Letter
============================================================
============================================================
43.) Annular vasculitis associated with pregnancy.
============================================================
Br J Dermatol 1993 Nov;129(5):599-601
Kelly RI, Cook MG, Marsden RA
Department of Dermatology, St George's Hospital, London, U.K.
A 29-year-old woman presented in the 31st week of pregnancy with an unusual
bilateral, erythematous eruption on the posterior calves, which clinically
resembled erythema annulare centrifugum. A biopsy showed features of a mild
leucocytoclastic vasculitis. Within 2 days of delivery the rash had almost
resolved, suggesting that its activity was related to the pregnancy. The
diagnosis is consistent with 'annular vasculitis', which we suggest
represents a distinct variant of leucocytoclastic vasculitis, and a distinct
clinicopathological entity. We are not aware of any previous reports of an
association between annular vasculitis and pregnancy.
============================================================
44.) Inflammatory carcinoma masquerading as erythema annulare
centrifugum.
============================================================
Acta Derm Venereol 1993 Apr;73(2):138-40
Reichel M, Wheeland RG
Department of Dermatology, University of California, Davis, Sacramento
95816.
A case of inflammatory carcinoma, or carcinoma erysipelatodes, clinically
resembling erythema annulare centrifugum is reported. The cutaneous
inflammatory carcinoma was due to metastasis by a signet-ring cell
adenocarcinoma, probably of gastrointestinal origin. This is the third
reported case of inflammatory carcinoma with signet-ring cell infiltration.
Cancer patients with atypical or unusual inflammatory dermatoses should be
evaluated by skin biopsy because of the possible association with the
internal neoplastic process.
============================================================
45.) [Darier's erythema annulare centrifugum and primary Vaquez
polycythemia]
============================================================
SO - Ann Dermatol Venereol 1984;111(8):767-8
AU - Triller R; Renard T; de Lacharriere O; Leonard F; Caulet T; Kalis B
PT - JOURNAL ARTICLE
============================================================
============================================================
46.) Recurrent annular erythema with anti-SSA/Ro and anti-SSB/La antibodies
localized on palms and fingers in an elderly man.
============================================================
SO - Lupus 1994 Feb;3(1):65-7
AU - Satoh M; Ajmani AK; Yamagata H; Okubo K; Akizuki M
PT - JOURNAL ARTICLE
AB - A 69-year-old Japanese man with recurrent annular erythema localized on
palms and flexor surface of fingers with anti-SSA/Ro and anti-SSB/La
antibodies, is reported. The present case indicates that even in an elderly
man with atypical localization, annular erythema with autoimmunity may be
considered and serological analysis should be performed. Systematic studies
will be required to understand the relationship between 'recurrent annular
erythema associated with anti-SSB/La antibodies' in Japanese, subacute
cutaneous lupus erythematosus (SCLE) and 'annular erythema associated with
Sjogren's syndrome'.
============================================================
47.) Clinical and immunological analysis of annular erythema associated with
Sjogren syndrome.
============================================================
SO - Dermatology 1994;189 Suppl 1:14-7
AU - Katayama I; Yamamoto T; Otoyama K; Matsunaga T; Nishioka K
PT - JOURNAL ARTICLE
AB - Clinical and immunopathological analysis was performed on 24 cases of
Sjogren syndrome with annular erythema (AESjS). AESjS predominantly appears
on the cheek of the face where skin temperature is relatively low in
comparison with other sites. VCAM-1 and ICAM-1 were strongly expressed on
endothelial cells of AESjS, while epidermal expression of ICAM-1 was focal
and weak. VCAM-1 mRNA expression was also much more intense compared to
systemic lupus erythematosus. The lymphocyte response to staphylococcal
enterotoxin B was higher in AESjS than that of controls, and cells positive
for T cell receptor V beta 6,9,12 were expanded after the culture.
Superantigen-driven endothelial-cell-dependent T cell infiltration to the
skin plays a crucial role in AESjS.
============================================================
48.) Clinical, serological and immunogenetic features of Japanese
anti-Ro/SS-A-positive patients with annular erythema.
============================================================
SO - Dermatology 1994;189 Suppl 1:11-3
AU - Miyagawa S
PT - JOURNAL ARTICLE
AB - Sixteen anti-Ro/SS-A-positive patients with recurrent annular erythema,
which has recently been recognized as a unique cutaneous manifestation of
Sjogren's syndrome, were studied. Eight of the 16 patients met the American
Rheumatism Association criteria for systemic lupus erythematosus. Fifteen
patients had anti-La/SS-B antibodies. Antibodies against U1RNP were detected
in 2 patients with systemic lupus erythematosus, 1 with anti-Sm antibodies.
Patterns of autoimmune response to Ro/SS-A antigens were variable by
immunoblot analysis. HLA typing by the standard complement-dependent
microcytotoxicity assay revealed that all the 16 patients were positive for
HLA-DRw52 antigens but negative for either HLA-B8 or HLA-DR3 which is
reportedly associated with the autoimmune response to Ro/SS-A antigens in
white and black patients.
============================================================
49.) Persistent annular erythema of infancy.
============================================================
SO - Pediatr Dermatol 1993 Mar;10(1):46-8
AU - Helm TN; Bass J; Chang LW; Bergfeld WF
PT - JOURNAL ARTICLE
AB - Annular erythema of infancy is an uncommon, nonpruritic, figurate
erythema that begins in the first year of life. Biopsy specimens reveal a
perivascular and interstitial lymphocytic infiltrate with numerous
eosinophils. The cause of the disorder is unknown, but a hypersensitivity
response to unrecognized antigens is suspected. The disorder is
self-limited, but may last for many months. In our patient the eruption
continued 19 months after its onset.
============================================================
50.) HLA antigens in anti-Ro(SS-A)-positive patients with recurrent annular
erythema.
============================================================
SO - J Am Acad Dermatol 1993 Feb;28(2 Pt 1):185-8
AU - Miyagawa S; Dohi K; Shima H; Shirai T
PT - JOURNAL ARTICLE
AB - BACKGROUND: Recurrent annular erythema associated with the
anti-Ro(SS-A) antibody response has recently been reported in Orientals. The
association is assumed to represent a distinct clinical entity. OBJECTIVE:
Our purpose was to extend knowledge on the immunogenetic spectrum of the
disease. METHODS: Sixteen anti-Ro(SS-A)-positive Japanese patients with
recurrent annular erythema and Sjogren's syndrome were studied. The standard
complement-dependent microcytotoxicity assay was used to type the HLA-A, -B,
-C, -DR, and -DQ, as well as the HLA-DRw52 and -DRw53 antigens. RESULTS: All
16 patients were positive for HLA-DRw52 antigens as compared with 52% of
control subjects (p 0.01 relative risk 14.8). No significant deviations were
noted in the phenotype frequencies for HLA-A, -B, -C, and -DQ antigens.
CONCLUSION: HLA-DRw52 is closely related to annular erythema in
anti-Ro(SS-A)-positive Japanese patients with Sjogren's syndrome.
============================================================
51.) Urticated annular erythema: a new manifestation of Sjogren's
syndrome.
============================================================
SO - Clin Exp Dermatol 1993 Jan;18(1):50-1
AU - Ostlere LS; Harris D; Rustin MH
PT - JOURNAL ARTICLE
AB - A patient with a unique urticated annular erythema associated with
Sjogren's syndrome and some features of systemic lupus erythematosus (SLE)
is reported. There has been one previous report of a similar eruption
occurring in a patient with Sjogren's syndrome.
============================================================
52.) Recurrent annular erythema associated with
anti-SS-============================================================
B/La antibodies: analysis of the disease-specific epitope.
SO - Br J Dermatol 1992 Dec;127(6):608-13
AU - Hoshino Y; Hashimoto T; Mimori T; Akizuki M; Nishikawa T
PT - JOURNAL ARTICLE
AB - We have found that anti-SS-B/La antibodies are present in a group of
patients with a characteristic recurrent annular erythema, and immunological
abnormalities. The presence of a disease-specific epitope for this entity
has been examined by comparing immunological reactivity of anti-SS-B/La
antibodies between these patients and patients with classical Sjogren's
syndrome who have anti-SS-B/La antibodies but do not have this
characteristic erythema. In immunoblotting using three different antigen
sources, all the sera from both groups exhibited the same reaction patterns.
V8 protease mapping showed that the sera could be divided into three groups
by the difference in reactivity to two main digested peptide fragments.
However, no significant relationship of the reactivity in peptide mapping
between the two patient groups was observed. Further studies are necessary
to elucidate the role of anti-SS-B/La antibodies in disease pathogenesis in
these patients, in particular by more precise peptide mapping using
recombinant SS-B/La antigen proteins.
============================================================
53.) Erythema annulare centrifugum associated with gold sodium thiomalate
therapy.
============================================================
SO - J Am Acad Dermatol 1992 Aug;27(2 Pt 2):284-7
AU - Tsuji T; Nishimura M; Kimura S
PT - JOURNAL ARTICLE
AB - Two women with rheumatoid arthritis developed erythema annulare
centrifugum while receiving gold thiomalate therapy. Both patients had
similar clinical and histologic findings. Results of a lymphocyte
stimulation test were positive in one patient but not in the other.
============================================================
54.) Annular erythema. A comparative study of Sjogren syndrome with subacute
cutaneous lupus erythematosus.
============================================================
SO - Int J Dermatol 1991 Sep;30(9):635-9
AU - Katayama I; Teramoto N; Arai H; Nishioka K; Nishiyama S
PT - JOURNAL ARTICLE
AB - Annular erythema developed in 22 patients with Sjogren syndrome.
Clinically, the annular erythema was subdivided into three forms: Sweet
disease-like annular erythema with an elevated border (14 cases); subacute
cutaneous lupus erythematosus (SCLE)-like marginally scaled erythema (5
cases); and papular erythema (3 cases). Histopathologically, features
commonly seen in annular erythema are deep perivascular and/or
periappendageal infiltration of the lymphocytes with an admixture of
neutrophils or plasma cells and less frequent epidermal changes suggestive
of cutaneous lupus erythematosus. Immunoglobulin or complement deposition
along the dermoepidermal junction of lesional skin was observed in 8 of 18
cases, and most of the dermal infiltrates consisted of CD4(+), 4B4(+) cells.
The appearance of anti-SS-A(Ro) (100%) and anti-SS-B(La) (77%) was
significantly higher in patients with annular erythema. These results
suggest that patients with Sjogren syndrome might have a distinct annular
erythematous lesion that is both clinically and histopathologically
different from SCLE, although close immunologic abnormalities exist in these
two diseases.
============================================================
55.) Annular erythema associated with Sjogren's syndrome: a variant of
systemic lupus erythematosus [see comments]
============================================================
SO - J Am Acad Dermatol 1991 Sep;25(3):557-60
AU - Ruzicka T; Faes J; Bergner T; Peter RU; Braun-Falco O
PT - COMMENT; JOURNAL ARTICLE
AB - We present a Burmese patient with widespread annular erythema
associated with Sjogren's syndrome. Unlike previously described cases, the
disease occurred in the setting of systemic lupus erythematosus.
Photoprovocation testing revealed light sensitivity in the UVA range with
elicitation of subacute cutaneous lupus erythematosus-like lesions. The
presence of an erythema annulare centrifugum-like eruption should initiate
the search for Sjogren's syndrome and systemic lupus erythematosus.
============================================================
56.) Lymphocyte response to staphylococcal enterotoxin B in patients with
annular erythema associated with Sjogren syndrome.
============================================================
SO - J Dermatol 1991 Feb;18(2):63-8
AU - Katayama I; Asai T; Nishiyama S; Nishioka K
PT - JOURNAL ARTICLE
AB - Lymphocyte response to staphylococcal enterotoxin B (SEB) was analysed
in 11 cases with Sjogren syndrome (SjS) who developed annular erythema
during the course. Increased lymphocyte response against SEB was observed on
day 5 in those patients who developed annular erythema at the time of
examination. A similar reaction pattern was observed when Con A and PWM, but
not protein A, were used as the mitogen. No significant lymphocyte response
was observed in the patients in the inactive stage without annular erythema
or in normal controls. Furthermore, peripheral blood lymphocytes express
LFA-1 after SEB stimulation. These results suggest that lymphocytes from SjS
patients react to various types of antigenic or mitogenic stimulation and
that they express cell adhesion molecules, especially in patients with
active annular erythema.
============================================================
57.) ICAM-1 and LFA-1 expressions in the lesional skin of annular erythema
associated with Sjogren syndrome.
============================================================
SO - J Dermatol 1990 Dec;17(12):719-23
AU - Katayama I; Asai T; Nishiyama S; Nishioka K
PT - JOURNAL ARTICLE
AB - ICAM-1 and LFA-1 expression was studied in the lesional skin of ten
cases of annular erythema associated with Sjogren syndrome. Most of the
infiltrating mononuclear cells around blood vessels expressed LFA-1 in
addition to its strong expression on vascular endothelial cells and focal
expression on the epidermal basal cell layer in 3 cases. ICAM-1 expression
on vascular endothelial cells was similar to LFA-1, although relatively
focal and weak expression was observed on mononuclear cells. ICAM-1
expression on keratinocytes was focal and limited to the basal cell layer in
annular erythema. These findings suggest that strong expression of ICAM-1 on
endothelial cells but not keratinocytes and LFA-1 on mononuclear cells might
play some role in the induction of skin lesions in annular erythema
associated with Sjogren syndrome.
============================================================
58.) Annular erythema associated with primary Sjogren syndrome: analysis of
T cell subsets in cutaneous infiltrates [see comments]
============================================================
SO - J Am Acad Dermatol 1989 Dec;21(6):1218-21
AU - Katayama I; Asai T; Nishioka K; Nishiyama S
PT - JOURNAL ARTICLE
AB - Immunohistochemical analysis was performed on the annular erythema
associated with Sjogren syndrome. This type of annular erythema is
characterized by a doughnutlike appearance with an elevated border and
central pallor; it is distinct from subacute cutaneous lupus erythematosus.
Histologically this erythema is characterized by coat sleeve-like
infiltration of lymphocytes around blood vessels and by nuclear debris in
the connective tissue. Vasculitis or epidermal changes suggestive of lupus
erythematosus were not observed in any of the cases, although immunoglobulin
or complement deposition along the basement membrane zone and focal
liquefaction degeneration of the basal layer in involved skin were seen in
some cases. Major dermal infiltrates consisted primarily of CD4+ and 4B4+
lymphocytes.
============================================================
59.) Annular erythema in identical twins.
============================================================
SO - Cutis 1989 Aug;44(2):139-40
AU - Watsky KL; Hansen T
PT - JOURNAL ARTICLE
AB - A case of superficial gyrate erythema that was indistinguishable from
erythema annulare centrifugum occurred in identical twins. We propose to
include a familial cause among the known causes of erythema annulare
centrifugum rather than considering this a separate entity, "familial
annular erythema."
============================================================
60.) Annular erythema: a possible association with primary Sjogren's
syndrome.
============================================================
SO - J Am Acad Dermatol 1989 Apr;20(4):596-601
AU - Teramoto N; Katayama I; Arai H; Eto H; Kamimura K; Uetsuka M; Kondo S;
Nishioka K; Nishiyama S
PT - JOURNAL ARTICLE
AB - In four patients with primary Sjogren's syndrome a distinct annular
erythema developed, which was characterized by a wide, elevated border
(which can be likened to a doughnut ring) and central pallor.
Histologically, there was a coat sleeve-like infiltration of lymphocytes
around blood vessels and nuclear debris in the connective tissue. Vasculitis
or epidermal changes suggestive of lupus erythematosus were not observed,
and there was no immunoglobulin deposition along the basement membrane zone.
This annular erythema may be a cutaneous manifestation of Sjogren's
syndrome.
============================================================
61.) Neonatal lupus syndrome and microtubular structure.
============================================================
SO - J Dermatol 1989 Feb;16(1):54-8
AU - Nitta Y; Ohashi M
PT - JOURNAL ARTICLE
AB - A female infant, at 6 weeks old, with the clinical manifestation of
annular erythemas on the trunk and face, was positive for anti-SS-A and
anti-SS-B antibodies. The annular erythema disappeared spontaneously at the
age of 7 months when anti-SS-A and anti-SS-B antibodies were negative.
Electron microscopic observation of the vascular endothelial cells on the
annular erythema revealed microtubular structures. Later microtubular
structures were found absent from the vascular endothelial cells of the area
where the annular erythema had disappeared. The patient's mother is
suffering from Sjogren's syndrome; she has no clinical symptoms but
anti-SS-A and anti-SS-B antibodies are positive and a biopsy of small
salivary glands of the lip demonstrated a marked periductal mononuclear cell
infiltration. Microtubular structures were observed in her vascular
endothelial cells in the small salivary gland region. These findings suggest
that disappearance of microtubular structure may have some relationship with
anti-SS-A and anti-SS-B antibodies.
============================================================
62.) Erythema annulare of infancy.
============================================================
SO - Cutis 1988 Oct;42(4):353-5
AU - Metzker A; Frumkin A
PT - JOURNAL ARTICLE
AB - A case of erythema annulare of infancy lasting for two years is
presented. The striking features of this overall annular eruption, of
idiopathic origin, are noted. This case is unusual because of the late onset
and the long duration of symptoms. Such cases warrant prolonged follow-up
examinations after the annular lesions disappear.
============================================================
63.) An annular erythema of infancy.
============================================================
SO - Arch Dermatol 1987 Apr;123(4):510-3
AU - Cox NH; McQueen A; Evans TJ; Morley WN
PT - JOURNAL ARTICLE
AB - An unusual annular and arciform erythema in an infant is reported. Skin
lesions appeared when the child was 4 days old, and multiple lesions have
been present during the subsequent two years. Individual lesions gradually
enlarge over a period of a few weeks, and they resolve spontaneously without
any residual cutaneous abnormality. This annular erythema is clinically and
histologically distinct from previously described annular erythemas of
infancy, with which it is compared.
============================================================
64.)Reactive annular erythema after intramuscular vitamin K.
============================================================
SO - Cutis 1986 Jun;37(6):445-8
AU - Kay MH; Duvic M
PT - JOURNAL ARTICLE
AB - We present a case of a 70-year-old woman who received multiple
intramuscular vitamin K injections before undergoing an invasive diagnostic
procedure. Four weeks later she noted enlarging annular erythematous plaques
at the sites of each injection. Although this occurrence has been recognized
in the European literature, it either occurs less frequently in the United
States or is not commonly reported. This is the second case report in the
English literature.
============================================================
65.) Annular erythema of infancy.
============================================================
SO - J Am Acad Dermatol 1986 Feb;14(2 Pt 2):339-43
AU - Hebert AA; Esterly NB
PT - JOURNAL ARTICLE
AB - An urticarial annular erythema began in our patient at 6 weeks of age
and resolved completely by 14 months of age. Individual lesions lasted 2 to
several days and tended to erupt in cycles, with each cycle lasting 5 to 6
weeks. The lesions were totally asymptomatic and left no residual scaling or
hyperpigmentation. Histologically, a dense perivascular infiltrate of
lymphocytes, histiocytes, eosinophils, and a few plasma cells was evident.
The clinical appearance, course, and histologic characteristics resemble
closely the case reported by Peterson and Jarratt in 1981.
============================================================
66.) [Erythema annulare centrifugum revealing linear IgA dermatitis of
childhood]
============================================================
SO - Ann Dermatol Venereol 1986;113(12):1213-22
AU - Larregue M; Bressieux JM; Laidet B; Cavaroc Y; Gallet P; de Giacomoni
P; Touchard G
PT - JOURNAL ARTICLE
AB - Linear IgA dermatitis was diagnosed in a 13-year old girl with erythema
annulare centrifugum (EAC) on the basis of the criteria laid down by
Jablonska: vesiculo-bullous eruption with specific patterns on subsequent
flare-ups, subepidermal vesicles and bullae with papillary eosinophilic
abscesses in erythematous areas, positive linear IgA antibody response at
direct immunofluorescence in the lamina basal, absence of intolerance to
gluten and responsiveness to sulfapyridine and dapsone. This patient was
followed up for 10 years. During the first 5 years any attempt at
withdrawing dapsone resulted in quick relapse which always remained
responsive to that drug. After 5 years discontinuing dapsone was no longer
followed by relapse, and the girl was considered clinically cured. Yet
direct immunofluorescence in healthy skin remained positive for 2 years
after treatment was stopped, as has previously been reported. At the age of
23, after 5 years without treatment the patient remained cured. This case
demonstrates that linear IgA dermatitis is one of the causes of EAC.
Autoimmune bullous diseases, such as pemphigus with eosinophilic spongiosis,
bullous pemphigoid and dermatitis herpetiformis, are known to present as
EAC. Direct cutaneous immunofluorescence is necessary to the aetiological
diagnosis of EAC.
============================================================
67.) Erythema annulare centrifugum: an unusual case due to
hydroxychloroquine sulfate.
============================================================
SO - Cutis 1985 Aug;36(2):129-30
AU - Hudson LD
PT - JOURNAL ARTICLE
AB - Erythema annulare centrifugum presents as a cutaneous hypersensitivity
to diverse causes including fungal and yeast infections, parasitic
infestations, drugs, and, rarely, occult malignancies. A prolonged case of
erythema annulare centrifugum secondary to the use of hydroxychloroquine
sulfate is presented. The prolonged time needed for clearing after
discontinuation of the medication is thought to result from the
melanocyte-binding characteristics of the drug.
============================================================
68.) 'Persistent' annular erythema of infancy.
============================================================
SO - Arch Dermatol 1984 Aug;120(8):1069-72
AU - Toonstra J; de Wit RF
PT - JOURNAL ARTICLE
AB - An unusual annular erythema occurred in a 6-month-old girl. Recurrent
annular lesions appeared on the face and back, but annular lesions persisted
for ten months on the distal extremities. Eleven months after the eruption
appeared, it resolved completely without recurrence. This seemingly unique
condition is compared with other cases of chronic annular erythemas,
especially those previously described as erythema gyratum perstans.
============================================================
69.) Erythema annulare centrifugum associated with ascariasis.
============================================================
SO - Arch Dermatol 1981 Sep;117(9):582-5
AU - Hendricks AA; Lu C; Elfenbein GJ; Hussain R
PT - JOURNAL ARTICLE
AB - Erythema annulare centrifugum (EAC) is a figurate erythema that has
been associated with man diverse entities. A case of EAC was related to
infestation by the nematode, Ascaris lumbricoides. A careful examination of
the patient did not define an immunologic basis for EAC. Results of
lymphocyte stimulation tests of the patient showed an immune response to A
lumbricoides extracts but not to A suum extracts. This finding is of
practical importance, since most laboratoires use A suum extracts in routine
skin and serologic tests for human ascariasis.
============================================================
70.) Annular erythema of infancy.
============================================================
SO - Arch Dermatol 1981 Mar;117(3):145-8
AU - Peterson AO Jr; Jarratt M
PT - JOURNAL ARTICLE
AB - The lesions of an unusual annular erythema in an infant evolved from
erythematous papules, to rings, to interrupted arcs over 36 to 48 hours, and
then resolved without a trace. New lesions appeared and evolved with
remarkable uniformity for eight months and then disappeared. This seemingly
unique eruption is compared with other annular erythemas described in
infants.
============================================================
71.) Annular erythema as an unusual manifestation of chronic disseminated
lupus erythematosus.
============================================================
SO - Arch Dermatol 1980 Apr;116(4):450-3
AU - Maciejewski W
PT - JOURNAL ARTICLE
AB - Numerous annular erythematous lesions developed in a 47-year-old woman,
involving most of the integument. Thorough clinical, histopathologic, and
immunopathologic investigations confirmed the diagnosis of lupus
erythematosus. Unusual clinical, histologic, and immunofluorescence
microscopy patterns emerged during the course of the disease, which was
resistant to treatment.
============================================================
72.) Multiple annular erythema [letter]
============================================================
SO - J Dermatol 1994 Sep;21(9):699-700
AU - Miyoshi H; Kanzaki T
PT - LETTER
============================================================
============================================================
73.) Reactive erythemas: erythema annulare centrifugum and erythema gyratum
repens.
============================================================
SO - Clin Dermatol 1993 Jan-Mar;11(1):135-9
AU - Tyring SK
PT - JOURNAL ARTICLE; REVIEW (57 references); REVIEW, TUTORIAL
============================================================
============================================================
74.) [Squamous erythema annulare centrifugum]
============================================================
SO - Ann Dermatol Venereol 1993;120(3):237-40
AU - Petit A; Nahmias M; Gaulier A; Sigal-Nahum M; Ruzniewsky P; Belaich
S
PT - JOURNAL ARTICLE
AB - A case of squamous erythema annulare centrifugum has been observed. It
was characterized by striking clinical features and peculiar histological
findings, including necrosis of keratinocytes. A search for causative
factors was negative. Treatment with tar ointment (Brocq) rapidly resulted
in dramatic healing of the lesions; however, the usual features of annular
psoriasis were absent in our case.
============================================================
75.) Annular erythema associated with Sjogren's syndrome [letter;
comment]
============================================================
SO - J Am Acad Dermatol 1992 Aug;27(2 Pt 1):276
AU - Katayama I; Teramoto N; Arai H; Nishiyama S; Nishioka K
PT - COMMENT; LETTER
============================================================
============================================================
76.) An intensive care unit nurse with a recurring annular lesion. Erythema
annulare centrifugum (EAC).
============================================================
SO - Arch Dermatol 1992 Jul;128(7):977, 980
AU - Janss G; Schmidt K; Gattuso P; Massa M; Welykyj S
PT - JOURNAL ARTICLE
============================================================
============================================================
77.) Erythema annular centrifugum in Q fever.
============================================================
SO - Int J Dermatol 1991 Jul;30(7):502
AU - Betlloch I; Amador C; Chiner E; Varona C; Carbonell C; Vilar A
PT - JOURNAL ARTICLE
============================================================
============================================================
78.) Erythema annulare centrifugum caused by hydrochlorothiazide-induced
interstitial nephritis.
============================================================
SO - Int J Dermatol 1988 Mar;27(2):129-30
AU - Goette DK; Beatrice E
PT - JOURNAL ARTICLE
============================================================
============================================================
79.) [Erythema annulare centrifugum disclosing hyperthyroidism]
============================================================
SO - Ann Dermatol Venereol 1988;115(6-7):721-3
AU - Launay P; Blanc D; Paris B; Quencez E; Drobacheff C; Zultak M
PT - JOURNAL ARTICLE
============================================================
============================================================
80.) Eruption resembling erythema annulare centrifugum due to thiacetazone
[letter]
============================================================
SO - Australas J Dermatol 1987 Apr;28(1):44
AU - Ramesh V
PT - LETTER
============================================================
============================================================
81.) [Erythema annulare centrifugum caused by aldactone]
============================================================
SO - Ann Dermatol Venereol 1987;114(3):375-6
AU - Carsuzaa F; Pierre C; Dubegny M
PT - JOURNAL ARTICLE
============================================================
============================================================
82.) [On the physiopathology of erythema annulare centrifugum]
============================================================
SO - Ann Dermatol Venereol 1987;114(5):709-15
AU - Litoux P
PT - JOURNAL ARTICLE; REVIEW (22 references)
============================================================
============================================================
83.) Erythema annulare centrifugum associated with liver disease.
============================================================
SO - Arch Dermatol 1986 Nov;122(11):1239-40
AU - Tsuji T; Kadoya A
PT - JOURNAL ARTICLE
============================================================
============================================================
84.) [Erythema annulare centrifugum and Hashimoto's thyroiditis]
============================================================
SO - Ann Dermatol Venereol 1986;113(11):1087-8
AU - Thess F; Rigon JL; Cuny JF; Schmutz JL; Weber M; Beurey J
PT - JOURNAL ARTICLE
============================================================
============================================================
85.) Erythema annulare centrifugum associated with piroxicam [letter]
============================================================
SO - J Am Acad Dermatol 1985 Nov;13(5 Pt 1):840-1
AU - Hogan DJ; Blocka KL
PT - LETTER
============================================================
============================================================
86.) Annular erythema with histologic features of leukocytoclastic
vasculitis in ulcerative colitis.
============================================================
SO - Cutis 1985 Mar;35(3):250-2
AU - Aram H; Rubinstein N; Granot E
PT - JOURNAL ARTICLE
============================================================
87.) Erythema annulare centrifugum and malignant histiocytosis--report of a
case.
============================================================
SO - Clin Exp Dermatol 1984 Nov;9(6):608-13
AU - Dodd HJ; Kirby JD; Chambers TJ; Stansfeld AG
PT - JOURNAL ARTICLE
============================================================
============================================================
88.) Pityrosporum infection in an infant with lesions resembling erythema
annulare centrifugum.
============================================================
SO - Arch Dermatol 1984 Mar;120(3):380-2
AU - Kikuchi I; Ogata K; Inoue S
PT - JOURNAL ARTICLE
AB - Erythematous, scaling patches over the face, torso, and extremities
developed in a 2-month-old female infant. The facial lesions enlarged and
became confluent, while the torso and leg lesions enlarged and assumed an
annular configuration. Spores of Pityrosporum ovale and Pityrosporum
orbiculare were found in large numbers in potassium hydroxide preparations
from these lesions, a finding confirmed by culture. Clotrimazole ointment
was applied, and the lesions resolved within one week, leaving
depigmentation. The findings in this case and those of erythema gyratum
atrophicans transiens neonatale resembled each other except for the
demonstration of Pityrosporum spores. We assume that the disorder in our
patient may represent superficial gyrate erythema (erythema annulare
centrifugum) induced by Pityrosporum spores.
============================================================
89.) Erythema annulare centrifugum: a review of 24 cases with special
reference to its association with underlying disease.
============================================================
SO - Clin Exp Dermatol 1983 Jul;8(4):383-7
AU - Mahood JM
PT - JOURNAL ARTICLE
============================================================
============================================================
90.) [Pemphigoid with recurrence of the centrifugal-development bullous
annular erythema type]
============================================================
SO - Ann Dermatol Venereol 1983;110(12):1021-2
AU - Jeanmougin M; Lemarchand-Venencie F; Ribrioux A; Bardy-Decrion I;
Civatte J
PT - JOURNAL ARTICLE
============================================================
============================================================
91.) [Bullous pemphigoid with an erythema annulare centrifugum appearance
and a bullous border]
============================================================
SO - Ann Dermatol Venereol 1983;110(12):1017-8
AU - Chouvet B; Barthelemy H; Forestier JY; Hermier C; Thivolet J
PT - JOURNAL ARTICLE
============================================================
============================================================
92.) [Erythema annulare centrifugum and antinuclear antibodies]
============================================================
SO - Ann Dermatol Venereol 1983;110(9):711-2
AU - Elnekave FL; Puissant A; Morel P; Noury-Duperrat G; Beltzer-Garelly
E
PT - JOURNAL ARTICLE
============================================================
============================================================
93.) Erythema annulare centrifugum. A case due to tuberculosis.
============================================================
SO - Int J Dermatol 1982 Nov;21(9):538-9
AU - Burkhart CG
PT - JOURNAL ARTICLE
============================================================
============================================================
94.) Erythema annulare centrifugum and Graves' disease [letter]
============================================================
SO - Arch Dermatol 1982 Sep;118(9):623
AU - Braunstein BL
PT - LETTER
============================================================
============================================================
95.) Cimetidine-induced erythema annulare centrifugum: no cross-sensitivity
with ranitidine.
============================================================
SO - Br Med J (Clin Res Ed) 1981 Sep 12;283(6293):698
AU - Merrett AC; Marks R; Dudley FJ
PT - JOURNAL ARTICLE
============================================================
============================================================
96.) [Nosologic problems posed by a case of desquamative erythema annulare
centrifugum]].
============================================================
Bull Soc Fr Dermatol Syphiligr 1971;78(1):55
[Article in French]
Chasseuil M
============================================================
============================================================
97.) [Erythema annulare centrifugum Darier as a reaction form in diseases of
the reticulo-histiocyte system].
============================================================
Dermatol Wochenschr 1967 May 27;153(21):604-12
[Article in German]
Kimmig J, Rohde B, Janner M
============================================================
============================================================
98.) [Erythema annulare centrifugum of Darier, squamous variety].
============================================================
Bull Soc Fr Dermatol Syphiligr 1966 Jan-Feb;73(1):111-3
[Article in French]
Labouche F, Henaff R
============================================================
============================================================
99.) [Erythema annulare centrifugum with loco-regional recurrences during
the course of tuberculous coxitis. Focal reaction to tuberculin].
============================================================
Bull Soc Fr Dermatol Syphiligr 1965 May-Jun;72(3):259-62
[Article in French]
Coste F, Piguet B, Bontoux D
============================================================
100.) The Gyrate Erythemas
============================================================
seminars of dermatology 1984 Dec;3(4):327-336
Harry J. Hurley, MD, Jeffrey P.
============================================================
===========================================
101) ERYTHEMA ANNULARE CENTRIFUGUM. A CASE DUE TO HYPERSENSITIVITY TO BLUE
CHEESE PENICILLIUM.
SHELLEY WB.
===========================================
Arch Dermatol. 1964 Jul;90:54-8.
=====================================================================
102.) Erythema annulare centrifugum in a patient with crohn disease.
=====================================================================
J Cutan Med Surg. 2012 Nov-Dec;16(6):442-4.
Samycia M1, Salopek TG.
Author information
1Division of Dermatology and Cutaneous Sciences, University of Alberta,
Edmonton, AB T6G 2G3.
Abstract
BACKGROUND:
Erythema annulare centrifugum (EAC) represents a hypersensitivity reaction
to a variety of conditions, many of which have been reported in the
literature.
METHODS AND RESULTS:
We report on a 38-year-old woman with a 5-year history of recurrent
polycylic, arcuate, scaly, erythematous patches with central clearing on
her thighs and trunk. Clinical examination and biopsy were both consistent
with a diagnosis of EAC. Two years after the initial presentation, she was
diagnosed with mild Crohn disease.
CONCLUSIONS:
The prolonged nature of EAC in our patient and our inability to identify
known associations of malignancies, including medications, connective
tissue disorders, systemic disorders, and infections, led us to postulate
that her EAC was related to her Crohn disease. A thorough review of the
literature failed to detect any previous reports linking Crohn disease and
EAC.
======================================================
103.) Erythema annulare centrifugum associated with herpes zoster.
======================================================
J UOEH. 2012 Sep 1;34(3):225-9.
Ohmori S1, Sugita K, Ikenouchi-Sugita A, Nakamura M.
Author information
1Department of Dermatology, School of Medicine, University of Occupational
and Environmental Health, Japan.
Abstract
Erythema annulare centrifugum (EAC) presents as erythematous or urticarial
papules, each with an annular shape, that exhibit peripheral extension.
Internal malignancies are occasionally associated with EAC, and infectious
diseases, including fungal, bacterial or viral infections, have also been
regarded as possible causes of EAC. A 35-year-old man had a 1-week history
of a painful vesicular eruption over the trunk corresponding to dermatomes
Th8-10. Concomitantly, he developed several annular eruptions over the
trunk. We diagnosed the former lesions as herpes zoster and the latter as
EAC associated with herpes zoster. Although DNA was extracted from the EAC
region, no varicella-zoster virus DNA was detected. We consider that this
is Wolf's isotopic response, which is caused by an alteration of the local
immunity due to viral infection. An etiologic relationship between EAC and
herpes zoster is strongly suggested by the present case and by our
review.
==========================================================
104.) Paraneoplastic erythema annulare centrifugum eruption: PEACE.
========================================================
Am J Clin Dermatol. 2012 Aug 1;13(4):239-46. doi:
10.2165/11596580-000000000-00000.
Chodkiewicz HM1, Cohen PR.
Author information
1Medical School, The University of Texas Houston Medical School, Houston,
TX, USA.
Abstract
Erythema annulare centrifugum is a reactive erythema of various possible
etiologies including, although less often, an associated cancer.
Cancer-related erythema annulare centrifugum is most commonly associated
with lymphoproliferative malignancies, specifically lymphoma and leukemia.
Malignancy-associated erythema annulare centrifugum is more frequently
seen in women than men and the presence of skin lesions usually precedes
the clinical diagnosis of the underlying malignancy. Neoplasm-derived
erythema annulare centrifugum lesions often resolve following treatment of
the cancer. Recurrence of erythema annulare centrifugum may occur along
with the relapse of the underlying malignancy. Paraneoplastic erythema
annulare centrifugum eruption (PEACE) is speculated to be a result of a
cytokine or other tumor-associated factors.
=====================================================================
105.) The expanding spectrum of cutaneous borreliosis.
===================================================================
G Ital Dermatol Venereol. 2009 Apr;144(2):157-71.
Eisendle K1, Zelger B.
Author information
1Department of Dermatology and Venerology, Innsbruck Medical University,
Innsbruck, Austria. Klaus.eisendle@uki.at
Abstract
The known spectrum of skin manifestations in cutaneous Lyme disease is
continuously expanding and can not be regarded as completed. Besides the
classical manifestations of cutaneous borreliosis like erythema
(chronicum) migrans, borrelial lymphocytoma and acrodermatitis chronica
atrophicans evidence is growing that at least in part also other skin
manifestations, especially morphea, lichen sclerosus and cases of
cutaneous B-cell lymphoma are causally related to infections with
Borrelia. Also granuloma annulare and interstitial granulomatous
dermatitis might be partly caused by Borrelia burgdorferi or similar
strains. There are also single reports of other skin manifestations to be
associated with borrelial infections like cutaneous sarcoidosis,
necrobiosis lipoidica and necrobiotic xanthogranuloma. In addition, as the
modern chameleon of dermatology, cutaneous borreliosis, especially
borrelial lymphocytoma, mimics other skin conditions, as has been shown
for erythema annulare centrifugum or lymphocytic infiltration (Jessner
Kanof) of the skin.
==========================================
106.) Linear IgA dermatosis presenting with erythema annulare centrifugum
lesions: report of three cases in adults.
========================================
J Eur Acad Dermatol Venereol. 2001 Mar;15(2):167-70.
Dippel E1, Orfanos CE, Zouboulis C.
Author information
1Department of Dermatology, University Medical Center Benjamin Franklin,
The Free University of Berlin, Germany.
Abstract
Linear IgA dermatosis presented with erythema annulare centrifugum lesions
in three elderly women. Search for underlying malignancy revealed
low-grade B-cell lymphoma in one case. In addition to subepidermal
blistering, histology showed a typical mixed infiltrate of granulocytes
and eosinophils and, occasionally, papillar microabsesses in one case. In
the two other subjects, characteristic subepidermal lining with
granulocytes was observed. Immunofluorescence studies confirmed the
diagnosis, while autoantibodies characteristic for dermatitis
herpetiformis were absent. To our knowledge this is the second report of
adult linear IgA dermatosis in association with erythema annulare
centrifugum lesions. Our observations concord with several other reports
of figurate erythema associated with autoimmune blistering disease and
other immune disorders. Common antibody-related immunological mechanisms
indicate that the two distinct clinical pictures are probably stages of
the same pathogenic entity.
=====================================================
107.) A new type of annular erythema with perieccrine inflammation:
erythema papulatum centrifugum.
========================================================
Dermatology. 2013;226(4):298-301. doi: 10.1159/000348708. Epub 2013 Aug
14.
Ohmori R1, Kikuchi K, Yamasaki K, Aiba S.
Author information
1Department of Dermatology, Tohoku University Graduate School of Medicine,
Sendai, Japan.
Abstract
Erythema papulatum centrifugum (EPC) was first described in 1962 by
Watanabe [Jpn J Dermatol 1962;72:573] as eczematous lesions extending
centrifugally. To date, more than 150 cases have been reported, but only
in the Japanese literature. A review of the Japanese literature including
our 5 new cases reveals that EPC occurs in middle-aged persons,
predominantly in males, as a single lesion on the trunk that is
self-limiting but recurs frequently. Although EPC shares several
characteristics with the superficial type of erythema annulare centrifugum
or asymmetrical periflexural exanthema, EPC differs from erythema annulare
centrifugum in clinical manifestation, showing annular rings composed of
grouped, tiny papules, and in the histology of perieccrine inflammation,
while it differs from asymmetrical periflexural exanthema by male
preponderance, onset age, high relapse rate and unique annular
configuration. We discuss EPC as compared with other cutaneous disorders
showing annular erythema or similar histopathology and suggest that EPC is
a distinct clinical entity.
========================================================================
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