DERMAGIC EXPRESS / Dermatologia y Bibliografia - Dermatology & bibliography DERMAGIC EXPRESS / Dermatologia y Bibliografia - Dermatology & bibliography

viernes, 18 de julio de 2025

FINASTERIDE 5 MG AND 1 MG IN ANDROGENIC ALOPECIA. / FINASTERIDE 5 MG Y 1 MG EN ALOPECIA ANDROGENICA.


 Finasteride 5 Mgr vs 1 Mgr in Androgenic Alopecia. !


Finasteride 5 Mgr vs 1 Mgr en Alopecia Androgénica. !


Finasteride y alopecia androgenica


 

 EDITORIAL ENGLISH
 =================== 
Hello friends of the DERMAGIC network, back with a very hot topic: FINASTERIDE 5 MG VS FINASTERIDE 1 MG IN ANDROGENIC ALOPECIA.

The first article I found on this drug dates back to 1993, and others from 1994 discussed finasteride as a promising drug for various conditions such as acne, hirsutism, prostate cancer, and benign prostatic hyperplasia (BPH).

Later, it was discovered that finasteride was and is useful in the treatment of androgenetic alopecia.

But at that time, only the 5 MG version (PROSCAR) was available, and many people began using it twice a week: they would break the original pill into 4 parts, taking 1/4 of a pill daily. This motivated the company to market the 1 mg dosage form for exclusive use in ANDROGENIC ALOPECIA, under the name PROPECIA.

There are studies in which patients were given 5 mg 
FINASTERIDE daily for 2 years without side effects. Furthermore, the first report from 1993 showed that daily doses of 80 mg FINASTERIDE for 3 months caused no side effects.

However, subsequent studies showed that at doses of 1 mg, finasteride (Propecia), like all medications, has its side effects, mainly erectile dysfunction, mood swings, decreased semen volume, and in some cases, gynecomas and adenomas.

These reports appeared during the decade from 2010 to 2012, describing the so-called
POST-FINASTERIDE SYNDROME (PFS): which is still being discussed today, with symptoms that appear after prolonged treatment with this medication. I describe them as follows:

Symptoms included:

- Decreased libido.
- Erectile dysfunction.
- Changes in penile tissue.
- Loss of enjoyment or desire for sexual intercourse.
- Decreased sperm count.
- Gynecomastia, adenomas.
- Skin changes.
- Cognitive impairment: loss of memory and concentration.
- Fatigue.
- Anxiety, panic attacks.
- Depression.
- Suicidal ideation.
- Loss of muscle mass.
- Metabolic disorders.

MECHANISM PRODUCING THIS SYNDROME:

1.) FINASTERIDE inhibits the enzyme 5-alpha reductase type 2, blocking the conversion of testosterone to dihydrotestosterone (DHT), which is its main effect. This would cause an alteration in the levels of neuroactive steroids that regulate neurotransmitters such as GABA and serotonin in the brain.

2.) Alterations in hippocampal neurogenesis and changes in the gut microbiota that could influence symptoms have been detected.

3.) Genetic susceptibility and changes in androgen receptors and enzymes could be involved in the clinical manifestations.

Although this POST FINASTERIDE SYNDROME is documented and recognized by patients, it remains a topic of debate in the medical community today.

Among cases of female pattern baldness, 
FINASTERIDE was significantly more common with fetal damage and uterine disorders. Furthermore, drug-gene network analysis indicated that finasteride could profoundly alter pathways related to sex hormone signaling and oocyte maturation.

It was later discovered that 
FINASTERIDE is not useful in female pattern baldness, but is useful in HIRSUTISM.

HISTORICAL ACCOUNT:

Since it became known in the scientific world that 
FINASTERIDE produced hair growth, FINASTERIDE 5 mg (PROSCAR) began to be used, as I mentioned before, because FINASTERIDE 1 mg (PROPECIA) had not yet been marketed. The dosage: 10 mg weekly in 2 doses, Tuesdays and Thursdays, with good results.

Once FINASTERIDE 1 MG (PROPECIA) was released, the company began an AGGRESSIVE CAMPAIGN, stating that the dose had to be 1 MG daily for 7 days a week, which would be 7 MG total, versus the 10 MG twice weekly doses of FINASTERIDE 5 MG (PROSCAR).

The TRUTH is that FINASTERIDE 5 MG twice weekly is as good as or equal to FINASTERIDE 1 MG daily, and it's much cheaper, safer, and has fewer risks. A box of 30 tablets lasts 15 weeks (3 months and 3 weeks).

Perhaps one of the advantages that can be attributed to this regimen is that your body "rests" from the drug because you only take it twice a week, compared to taking 
FINASTERIDE 1 mg (PROPECIA) daily, from which your body doesn't rest; you always have the medicine "inside."

I went for the scientific route and used 
FINASTERIDE 5 mg in patients with androgenetic alopecia with the aforementioned regimen: 5 mg twice a week. After the fourth month, I observed significant improvement in the patients. See the attached photos.

CONCLUSIONS:

1.) 
FINASTERIDE is a wonderful product.

2.) 
FINASTERIDE5 mg twice a week is better than or equal to finasteride 1 mg daily.

3.) Merck S.D. launched PROPECIA for commercial and marketing purposes.

4.) FINASTERIDE IMPROVES PROSTATIC HYPERPLASIAIGNA (BPH), AND PRODUCES notable improvement in ANDROGENIC ALOPECIA...!!!

5.)
TOPICAL FINASTERIDE, under the name FINASTOPIC, was be marketed by ISDIN in 2024. This has been talked about since 2000; the topical formulation most likely has fewer side effects than the oral formulation. In some presentations it comes combined with the popular MINOXIDIL, which is also useful in hair loss.

Finally, FINASTERIDE has recently been used in the treatment of
HIDRADENITIS SUPURATIVA, in both men and women, with good results. Its use as a hormonal agent is also proposed for the treatment of acne.

And its competition also emerged: DUTASTERIDE, which, in addition to being an oral formulation, comes in ampoules for local injection into the scalp. This formulation is the most commonly used, as the oral formulation is not officially approved for the treatment of this condition and is used off-label, given the beneficial clinical effects obtained.

Here is the link to the update on SERENOA REPENS or SAW PALMETTO versus FINASTERIDE for ANDROGENIC ALOPECIA.

In these references, you will learn about FINASTERIDE, its uses, and some of its adverse effects.

Greetings to all.

Dr, José Lapenta. 



Finasteride 5 Mg en Alopecia Androgenica



























 EDITORIAL ESPAÑOL
===================
Hola amigos de la red DERMAGIC, de nuevo con ustedes con un tema bien caliente: FINASTERIDE 5 MG VS FINASTERIDE 1 MG EN ALOPECIA ANDROGENICA.
 
 El primer trabajo que encontré sobre esta droga data del año 1.993 y otros mas de 1.994 donde se hablaba del FINASTERIDE COMO UNA DROGA promisoria en algunas PATOLOGÍAS COMO Acné, Hirsutismo, Cáncer de Próstata e  Hiperplasia prostatica benigna (BHP). 

Posteriormente se descubrió que el FINASTERIDE era y es útil en el tratamiento de  la ALOPECIA ANDROGÉNICA.
 
Pero para esa fecha solo existía la presentación de 5 MG, (PROSCAR), y mucha gente lo comenzó a usar 2 VECES por semana:  picaba la pastilla original en 4 PARTES, para tomar 1/ 4 de pastilla diaria. Esto motivo al laboratorio a sacar al mercado la presentación de 1 MG para su uso exclusivo en la ALOPECIA ANDROGÉNICA, con el nombre de PROPECIA.

EXISTEN estudios donde a pacientes se les dio FINASTERIDE 5 MGRS DIA POR 2 AÑOS SIN EFECTOS COLATERALES, MAS AUN,, en el primer reporte de 1.993 se DEMOSTRÓ que dosis diarias de 80 MGR /dia de FINASTERIDE por 3 meses NO OCASIONABAN EFECTOS SECUNDARIOS.
 
Pero en estudios posteriores se comprobó que a dosis de 1 MG, el FINASTERIDE, (PROPECIA), como todo medicamento tiene sus efectos secundarios principalmente LA DISFUNCIÓN ERÉCTIL, cambios en el humor, disminución del volumen del semen, y en algunos casos GINECOMASTIA Y ADENOMAS. 
 
Estos reportes aparecieron para la decada del 2010 al 2012 describiéndose el llamado SÍNDROME POST FINASTERIDE (SPF): el cual es discutido hoy en dia, con síntomas que se presentan luego de tratamientos prolongados con este medicamentos y te describo: 
 
Los síntomas incluyeron:
 
- Disminución de la libido.
- Disfunción eréctil.
- Cambios en el tejido del pene. 
- Perdida del disfrute o deseo por la relación sexual.
- Disminución del recuento de espermatozoides.
- Ginecomastia, adenomas.
- Cambios en la piel.
- Deterioro cognitivo: perdida de la memoria y concentración. 
- Fatiga.
- Ansiedad, ataques de pánico. 
- Depresión.
- Ideación suicida. 
- Perdida de masa muscular.
- Trastornos metabólicos. 
 
MECANISMO PRODUCTOR DE ESTE SÍNDROME: 
 
1.) El FINASTERIDE inhibe la enzima 5-alfa reductasa tipo 2, bloqueando la conversión de testosterona a dihidrotestosterona (DHT), ese es su principal EFECTO, esto provocaría una alteración de los niveles de esteroides neuroactivos que regulan neurotransmisores como GABA y serotonina en el cerebro.
 
2.) Se ha detectado alteración en la neuro génesis del hipocampo y cambios en la microbiota intestinal que podrían influir en los síntomas.
 
3.) La susceptibilidad genética y cambios, en receptores androgénicos y enzimas, pudieran estar implicados en las manifestaciones clínicas..

A pesar de que este
SÍNDROME POST FINASTERIDE esta documentado y reconocido por pacientes, hoy dia sigue siendo un tema de debate en la comunidad medica.
 
Entre los casos de alopecia femenina, EL FINASTERIDE fue significativamente más concurrente con el daño al feto y el trastorno del útero. Además, el análisis de la red de fármacos-genes indicó que el FINASTERIDE podría alterar profundamente las vías relacionadas con la señalización de las hormonas sexuales y la maduración de los ovocitos. 
 
Posteriormente se dscubrio que el FINASTERIDE no es ÚTIL en la ALOPECIA ANDROGÉNICa femenina, pero si en el HIRSUTISMO.

RECUENTO HISTÓRICO:

Desde que se conoció en el mundo científico QUE EL FINASTERIDE producía crecimiento del cabello, comenzó a usarse el FINASTERIDE 5 MG (PROSCAR), como antes les mencione, porque el FINASTERIDE 1 MG (PROPECIA) no había salido al mercado. La dosis: 10 MG SEMANALES en 2 dosis, martes y jueves con BUEN RESULTADO. 

Una vez que salio al mercado el FINASTERIDE 1 MG, (PROPECIA), el laboratorio comenzó una CAMPAÑA AGRESIVA, diciendo que la dosis tenia que ser un 1 MG dia por 7 días a la semana, que serian 7 MG en total, versus los 10 MG en las 2 tomas semanales del FINASTERIDE 5 MG (PROSCAR). 

La VERDAD es que FINASTERIDE 5 MG 2 VECES SEMANAL es tan bueno o igual al FINASTERIDE 1 MG DIARIO, y el costo es muchísimo menor, mas seguro, menos riesgos. Una caja de 30 Tabs dura 15 semanas, (3 meses y 3 semanas). 
 
 Quizá una de las ventajas que puede atribuirsele a este esquema es que tu organismo ¨descansa¨ de la droga pues solo la tomas 2 veces semanal, en relación al FINASTERIDE 1 MG (PROPECIA) diario, del cual tu organismo no descansa, siempre tienes la medicina ¨adentro¨. 

Yo me fui por el lado científico y utilice el producto FINASTERIDE 5 MG       en pacientes con Alopecia Androgénica con el esquema antes dicho 5 MG 2 veces semanal y al 4to mes observe mejoría notable de los pacientes, vean las fotos del attach.

CONCLUSIONES:

1.) EL FINASTERIDE ES UN producto maravilloso. 

2.) EL FINASTERIDE 5 MG 2 veces semanal, es MEJOR o IGUAL que el FINASTERIDE 1 MG  DIARIO. 

3.) EL LABORATORIO MERCK.S.D LANZO la PROPECIA con fines COMERCIALES Y DE MERCADEO. 

4.)  EL FINASTERIDE MEJORA LA HIPERPLASIA PROSTÁTICA BENIGNA (HPB), Y PRODUCE mejoría notable en la ALOPECIA ANDROGÉNICA.. !!! 

5.) PARA el año 2024, salio al mercado el
FINASTERIDE TÓPICO, con el nombre de FINASTOPIC, por el laboratorio ISDIN. De esto se venia hablando desde el año 2000, muy probablemente la presentación tópica tiene menos efectos secundarios que la presentación oral; en algunas presentaciones viene combinado con el popular MINOXIDIL, el cual también es útil en la caída del cabello.
  
Para finalizar el FINASTERIDE a sido utilizado últimamente en el tratamiento de la HIDRADENITIS SUPURATIVA, tanto en hombres como mujeres con buen resultado. También se propone su uso como agente hormonal en el tratamiento del Acné.
 
Y también le salio su competencia: EL DUTASTERIDE,  el cual ademas de presentación oral, viene en ampollas para inyección local en el cuero cabelludo, siendo esta presentación la mas utilizada, pues la PRESENTACIÓN ORAL NO ESTA APROBADA OFICIALMENTE  para el tratamiento de esta patología, mas se usa off label, dado los efectos clínicos beneficiosos obtenidos.
 
Aquí te dejo el enlace a la actualización de la SERENOA REPENS o SAW PALMETTO versus el FINASTERIDE en la ALOPECIA ANDROGÉNICA. 

En estas referencias conocerás el FINASTERIDE , sus usos y algunos de sus efectos adversos. 

Saludos a todos ! 

Dr. José Lapenta.. 



================================================================== 
REFERENCIAS BIBLIOGRÁFICAS / BIBLIOGRAPHICAL REFERENCES 
================================================================== 

 F.- Relative safety and efficacy of finasteride for treatment of hirsutism (2004).
====================================================================         
1.) Five-year follow-up of patients with benign prostatic hyperplasia treated with  finasteride. 
2.) Therapeutic effects of finasteride in benign prostatic hyperplasia: a randomized  double-blind controlled trial. 
3.) The effect of finasteride on prostate volume, urinary flow rate and symptom score in  men with benign prostatic hyperplasia. 
4.) [5-alpha-reductase inhibitors]. 
5.) Benign prostatic hyperplasia. 
6.) The potential for hormonal prevention trials. 
7.) 5 alpha-reductase inhibition by finasteride (Proscar) in epithelium and stroma of human  benign prostatic hyperplasia. 
8.) Pharmacological treatment of benign prostatic hyperplasia with finasteride: a clinical  review. 
9.) Medical therapy for benign prostatic hyperplasia: A review of the literature. 
10.) Pretreatment with finasteride decreases perioperative bleeding associated with  transurethral resection of the prostate. 
11.) Urinary retention in patients with BPH treated with finasteride or placebo over 4  years. Characterization of patients and ultimate outcomes.The PLESS Study Group. 
12.) Dihydrotestosterone and the concept of 5alpha-reductase inhibition in human benign  prostatic hyperplasia. 
13.) Chronic treatment with finasteride daily does not affect spermatogenesis or semen  production in young men. 
14.) Management of androgenetic alopecia. 
15.) Finasteride in the treatment of men with frontal male pattern hair loss. 
16.) Androgenetic alopecia in men: the scale of the problem and prospects for treatment. 
17.) [Androgenetic alopecia, hirsutism and hypertrichosis]. 
18.) Medical treatments for balding in men. 
19.) Understanding and managing common baldness. 
20.) Finasteride: a review of its use in male pattern hair loss. 
21.) Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male  Pattern Hair Loss Study Group. 
22.) Genetic analysis of male pattern baldness and the 5alpha-reductase genes. 
23.) Effect of finasteride on human testicular steroidogenesis. 
24.) [Finasteride: a new drug for the treatment of male hirsutism and  androgenetic  alopecia]? 
25.) The 5 alpha-reductase system and its inhibitors. Recent development and its  perspective in treating androgen-dependent skin disorders. 
26.) Finasteride: a clinical review. 
27.) The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and  dihydrotestosterone concentrations in patients with male pattern baldness. 
28.) Finasteride: the first 5 alpha-reductase inhibitor. 
29.) Cytologic atypia in a 53-year-old man with finasteride-induced gynecomastia. 
30.) Reversible painful gynaecomastia induced by low dose finasteride (1 mg/day). 
31.) Measuring reversal of hair miniaturization in androgenetic alopecia by follicular counts 
in horizontal sections of serial scalp biopsies: results of finasteride 1 mg treatment of men  and postmenopausal women. 
32.) Improvement in androgenetic alopecia in 53-76-year-old men using oral finasteride. 
33.) New topical antiandrogenic formulations can stimulate hair growth in human bald  scalp grafted onto mice. 
34.) Current management of androgenetic alopecia in men. 
35.) Immunohistochemical localization of types 1 and 2 5alpha-reductase in human scalp. 
36.) The psychosocial consequences of androgenetic alopecia: a review of the research  literature. 
37.) Clinical dose ranging studies with finasteride, a type 2 5alpha-reductase inhibitor, in  men with male pattern hair loss. 
38.) The effects of finasteride on scalp skin and serum androgen levels in men with  androgenetic alopecia. 
39.) Adverse Effects and Safety of 5-alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review.
40.) Interventions for Female Pattern Hair Loss.
41.) Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases.
42.) Finasteride in Hidradenitis Suppurativa: A "Male" Therapy for a Predominantly "Female" Disease.
43.) Hidradenitis suppurativa treated with finasteride.
44.) The use of hormonal agents in the treatment of acne.
45.) Risk of gynecomastia and breast cancer associated with the use of 5-alpha reductase inhibitors for benign prostatic hyperplasia.
46.) Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome.
47.) Post-Finasteride Adverse Effects in Male Androgenic Alopecia: A Case Report of Vitiligo.
48.) Side Effects Related to 5 α-Reductase Inhibitor Treatment of Hair Loss in Women: A Review.
49.) 5 mg/day finasteride treatment for normoandrogenic Asian women with female pattern hair loss.
50.) Adverse effects of 5α-reductase inhibitors: What do we know, don't know, and need to know?
============================================================= 

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miércoles, 16 de julio de 2025

CAT'S CLAWS AND SHARK CARTILAGE, CANCER AND INFLAMMATIONS / UÑA DE GATO Y CARTILAGO DE TIBURON, CANCER E INFLAMACION.




  

Cat's Claws and Shark Cartilage, Anti tumor and anti-inflammatory effects !

 

  Uña de Gato y Cartilago de Tiburon, efectos antitumorales y antiinflamatorios !

 

 

 
Uña de gato y cartilago de tiburon

 


EDITORIAL ENGLISH
===================
Hello friends of the Net, DERMAGIC again with you. Today a quite interesting NON DERMATOLOGIC topic. THE CAT'S CLAW AND THE SHARK CARTILAGE:

 
Uña de Gato

 
THE CAT'S CLAW is not in fact the "fingernail of a cat", it is a plant from PERU called UNCARIA TOMENTOSA, to which have been  discovered some beneficent actions for the organism, being able to be used in: arthritis, rheumatism, bursitis, gout, immunologic deficiencies, intestinal permeability, intoxications, it inhibits the platelet aggregation and it acts as anti-inflammatory.in:  
 
USES OF CAT'S CLAW (UNCARIA TOMENTOSA):

1.) arthritis, osteoarthritis.
 
2.) rheumatism.
 
3.) bursitis.
 
4.) gout.
 
5.) immunologic deficiencies.
 
6.) intestinal permeability.
 
7.) intoxicationS.
 
8.) inhibits the platelet aggregation.
 
9.) anti-inflammatory.
 
10.) Anti-cancer activity (breas cancer, lung cancer, thyroid cancer).
 
11.) aids.
 
12.) Diabetes and others.

CAT'S CLAW CONCLUSIONS:

CAT'S CLAW (UNCARIA TOMENTOSA) is used today for various conditions, including:

It is a
NATURAL ANTI-INFLAMMATORY, used as a complementary treatment for arthritis and osteoarthritis.

It also
MODULATES and STRENGTHHENS THE IMMUNE SYSTEM, stimulating the production of white blood cells and preventing immunosuppressive states.

It has an
ANTIOXIDANT effect, due to its alkaloid and proanthocyanidin content, protecting cells from oxidative stress caused by free radicals.

Use in
INFECTIONS: It is used to prevent and treat mild bacterial infections and infections of the urinary, digestive, and respiratory tracts, due to its immune-boosting effect.

Other uses: Relief from chronic diseases such as gastritis, rheumatism, fibroids, polycystic ovary syndrome, support in healing and cell regeneration, 
 
Which demonstrate from this plant native from the Peruvian Amazon its usefulness today as anti-inflammatory and anti-tumor effects.

 
Cartilago de Tiburon

 
THE SHARK CARTILAGE is not left behind, as many studies have shown that its components have been used in conditions such: he has effects scientifically proven ANTI-TUMOR and ANTI-ANGIOGENESIS activities, its use has even been suggested in PSORIASIS (reference D). Other effects include: anti-inflammatory, analgesic, and suppression of atherogenesis.:  

USES OF SHARK CARTILAGE:

1,) ANTI-TUMOR-CANCER (tumor growth).
 
2.) ANTI ANGIOGENESIS (atherosclerosis, suppression of atherogenesis, TROMBOSIS).
 
3.) PSORIASIS.
 
4.) anti-inflammatory.
 
5.) analgesic.
 
6.) hemodialysis.
 
7.) fibrosis.
 
8.) viral and protozoan infections.
 
9.) hyperglycemia and others. 

CONCLUSIONS OF SHARK CARTILAGE:

Currently, SHARK CARTILAGE has its best effects on joints and
OSTEOARTHRITIS. Supplements containing shark cartilage (due to its chondroitin and collagen content) have been shown to be effective in reducing joint pain, and also have analgesic and anti-inflammatory effects.

It has also been tested in
PSORIASIS to reduce scaling and itching, but the results are controversial.

Regarding its anti-angiogenesis effects, there is a product called
NEOVESTAT or AE-941, a shark cartilage extract that has been studied in CANCER, for its effect on reducing blood vessel formation in tumor lesions. However, it is not approved as a therapy for this condition, and the results of the studies are controversial.

Thus, the greatest benefit of this natural medicine is in
JOINT HEALTH, and it is used today by many athletes as a supplement to maintain and improve joint health. 
 
 SUMMARY:
 
In these references you will know the chemical components of UNCARIA TOMENTOSA (CAT'S CLAW) and SHARK CARTILAGE and their beneficial effects on different diseases...So

The really TRUTH is that these products today in day they are a truthful sample that that these ALTERNATIVE medicines are occupying an important place in our SCIENTIFIC WORLD.

Greetings to all !

Dr. Jose Lapenta 



EDITORIAL ESPAÑOL 
===================
Hola amigos de la Red, DERMAGIC nuevamente con ustedes. Hoy en día un tema NO DERMATOLÓGICO  muy interesante: LA UÑA GATO Y EL CARTÍLAGO DEL TIBURÓN.

Cat's Claws


 
LA UÑA DE GATO no es de hecho la "uña de un gato", es una planta del PERÚ llamada UNCARIA TOMENTOSA, a la que se han descubierto algunas acciones benéficas para el organismo, pudiendo ser utilizada en: artritis, reumatismo, bursitis, gota, deficiencias inmunológicas, permeabilidad intestinal, intoxicaciones,  inhibe la agregación plaquetaria  y actúa  como anti-inflamatorio.

USOS DE LA UÑA DE GATO (UNCARIA TOMENTOSA):

1.) artritis, osteoartritis.


2.) reumatismo. 

3.) bursitis.

4.) gota.

5.) deficiencias inmunológicas.

6.) permeabilidad intestinal.

7.) intoxicaciones.

8.) inhibe la agregación plaquetaria.

9.) Antiinflamatorio.

10. Actividad anti cancerígena (cáncer de senos, cáncer de pulmón, cáncer de tiroides).

11.) SIDA.

12.) Diabetes y otros. 

CONCLUSIONES UÑA DE GATO:
 
 La UÑA DE GATO (UNCARIA TOMENTOSA) hoy dia se utiliza en diversas condiciones, a saber:
 
Es un ANTIINFLAMATORIO NATURAL, utilizado como tratamiento complementario en artritis y osteoartritis.
 
También tiene efectos de MODULACIÓN Y FORTALECIMIENTO DEL SISTEMA INMUNOLÓGICO, estimulado la producción de glóbulos blancos, evitando los estados inmunosupresivos.

Efecto
ANTIOXIDANTE, debido a su contenido de alcaloides y proantocianidinas, protege las células contra el estres oxidativo provocado por los radicales libres.
 
Uso en INFECCIONES: se utiliza para prevenir y tratar infecciones bacterianas leves e infecciones de las vias urinarias, digestivas y respiratorias, por su efecto de aumentar el estado inmune.

Otros usos: Alivio de enfermedades crónicas, como la gastritis, reumatismo, fibromas, ovario poliquistico, soporte en la cicatrización y regeneración de las células,

Que demuestran que esta planta proveniente de la Amazonía peruana es de gran utilidad hoy en día debido a sus demostrados efectos antiinflamatorios y antitumorales.

EL CARTÍLAGO DEL TIBURÓN no se queda atrás, tiene efectos ANTI-TUMORALES y ANTI-ANGIOGÉNESIS comprobados científicamente, incluso se ha sugerido su utilización en la PSORIASIS (referencia D). Otros efectos incluyen: anti-inflamatorio, analgésico, y supresor de la aterogénesis. 

 
Shark Cartilage

 
USOS DEL CARTÍLAGO DE TIBURÓN (SHARK CARTILAGE):
 
1,) ANTI-TUMOR-CANCER (crecimiento tumoral).

2.) ANTI-ANGIOGENESIS (aterosclerosis, supresión de la aterogénesis, TROMBOSIS).

3.) PSORIASIS.

4) antiinflamatorio.

5. analgésico.

6.) hemodiálisis.

7.) fibrosis.

8.) infecciones virales y protozoarias.

9.) hiperglucemia y otros.

CONCLUSIONES CARTÍLAGO DE TIBURÓN: 
 
Actualmente el CARTÍLAGO DE TIBURÓN, presenta sus mejores efectos en las articulaciones y OSTEOARTRITIS. los suplementos que contienen cartílago de tiburón (por su contenido de condroitin y colágeno) han demostrado ser efectivos para reducir el dolor articular, ademas tiene efectos analgésicos y antiinflamatorios. 
 
 También ha sido probado en la PSORIASIS,  para reducir la descamacion y prurito, pero los resultados son controversiales.
 
 Con respecto a los efectos ANTI-ANGIOGENESIS, existe un producto denominado NEOVESTAT o AE-941 que es extracto de CARTÍLAGO DE TIBURÓN al cual se ha estudiado en el CANCER, por su efecto en disminuir la formación  de vasos sanguíneos en las lesiones tumorales (cancer), mas no esta aprobado como terapia para el mismo, siendo los resultados de los estudios controversiales.
 
De modo que su mayor utilidad de esta medicina naturista, es en la SALUD de las ARTICULACIONES, siendo utilizado hoy dia por muchos deportistas como suplemento para conservar y mejorar la salud de las articulaciones.
 
 RESUMEN:
 
En estas  referencias conocerás los componentes químicos de la  UNCARIA TOMENTOSA (UÑA DE GATO) y CARTÍLAGO DE TIBURÓN y sus efectos beneficiosos sobre diferentes enfermedades ...De modo que:

La VERDAD realmente es que estos productos hoy en día son una muestra verídica que estos medicamentos ALTERNATIVOS están ocupando un lugar importante en nuestro MUNDO CIENTÍFICO.

Saludos a todos. !

Dr. Jose Lapenta.


=============================================================
BIBLIOGRAPHICAL REFERENCES / REFERENCIAS BIBLIOGRAFICAS
=============================================================
=============================================================== 
1.) Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. 
2.) Uncaria tomentosa (Willd.) D.C.: cat's claw, una de gato, or saventaro. 
3.) Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (una de gato). 
4.) Uncaria tomentosa (Willd.) DC.--ethnomedicinal use and new pharmacological, toxicological and botanical results. 
5.) Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa. 
6.) Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro. 
7.) Pentacyclic oxindole alkaloids from Uncaria tomentosa induce human endothelial cells to release a lymphocyte-proliferation-regulating factor. 
8.) Depletion of specific binding sites for estrogen receptor by Uncaria tomentosa. 
9.) Antiinflammatory actions of cat's claw: the role of NF-kappaB. 
10.) Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts.
11.) Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa.
12.) New polyhydroxylated triterpenes from Uncaria tomentosa.
13.) Plant metabolites. Structure and in vitro antiviral activity of quinovic acid glycosides from Uncaria tomentosa and Guettarda platypoda.
14.) [Phytochemical and biological study of Uncaria tomentosa].
15.) The alkaloids of Uncaria tomentosa and their phagocytosis-stimulating action].
16.) CAT'S CLAW (Una de Gato) #K725 INGREDIENTS: 
17.) The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line.
18.) Uncaria tomentosa-Adjuvant Treatment for Breast Cancer: Clinical Trial.
19.) Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition.
20.) Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis.
21.) Uncaria tomentosa acts as a potent TNF-alpha inhibitor through NF-kappaB.
22.) The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review.
23.) Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors.
24.) Quinovic acid glycosides purified fraction from Uncaria tomentosa induces cell death by apoptosis in the T24 human bladder cancer cell line.
25.) Antiproliferative and pro-apoptotic effects of Uncaria tomentosa in human medullary thyroid carcinoma cells.
26.) An active ingredient of Cat's Claw water extracts identification and efficacy of quinic acid.
27.) [Cat's Claw: an herb from the Peruvian Amazon].
28.) Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory
T cell preservation or both?
29.) Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects.
30.) Mitraphylline inhibits lipopolysaccharide-mediated activation of primary 31.) Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark.
32.) Synthesis and biological evaluation of quinic acid derivatives as anti-inflammatory agents.
 

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 CARTÍLAGO DE TIBURÓN / SHARK CARTILAGE
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 A.-  The essential anti-angiogenic strategies in cartilage engineering and osteoarthritic cartilage repair (2022).
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viernes, 11 de julio de 2025

EL SÍNDROME DE LARVA MIGRANS CUTÁNEO Y LAS MASCOTAS.THE CUTANEOUS LARVA MIGRANS SYNDROME AND PETS /


 El síndrome de Larva Migrans Cutáneo y las mascotas (perros y gatos). !!! 


 The Cutaneous Larva Migrans Syndrome and pets (dogs and cats). !!! 


The  cutaneous larva migrans syndrome

Actualizado 2025

 

EDITORIAL ESPAÑOL 
====================
Hola amigos de la red, DERMAGIC de nuevo con ustedes. El tema de hoy  EL SÍNDROME LARVA MIGRANS CUTÁNEA, Y LAS MASCOTAS (PERROS Y GATOS)  

Nos encantan las mascotas, sobre todo los perros y gatos. Pero en la mierda (caca) de estos bellos animales hay unos parásitos que pueden pasar a la piel cuando la tocamos o ingerimos, 

 El sitio favorito para contraerla es la PLAYA o el CAMPO donde nuestras  lindas mascotas hacen  su mierda. Luego venimos nosotros e ingenuamente ponemos en contacto alguna parte de nuestro cuerpo (principalmente el pie) con el pupú-caca, y la larva penetra nuestra piel directamente desde las heces provocando la enfermedad. 

También en los hogares donde hay perros y gatos no controlados por el veterinario. En fin una enfermedad más donde el hombre es  accidentalmente contaminado por el animal. 

Hoy en dia descrita en algunas publicaciones como "el souvenir de los viajeros y turistas" que la contraen en sus viajes de vacaciones. Varios parásitos son los agentes causales pero los más comunes son: ANCYLOSTOMA CANInum y ANQUILOSTOMA. BRAZILIENSE. 

OTROS AGENTES CAUSALES:

- Ancylostoma ceylanicum, A. tubaeforme (perros y gatos)

- Gnathostoma spinigerum (gatos, perros, cerdos)
 
- Uncinaria stenocephala (perros en Europa)

- Bunostomum phlebotomum (ganado)

- Pelodera strongyloides

- En raros casos, Ancylostoma duodenale, Necator americanus (uncinarias humanas), y strongyloides stercoralis.
 
 La LARVA MIGRANS CUTÁNEA, es una enfermedad SUPERFICIAL, el parásito vive en la capa superficial de la piel, haciendo túneles a medida que crece, denominada también "erupción progresiva o serpigimosa", pero es auto limitada y con un buen tratamiento desaparece sin dejar complicaciones en la mayoría de los casos.
 
La LARVA MIGRANS CUTÁNEA presenta una variante denominada PANICULITIS NODULAR MIGRATORIA:  se presenta cuando las larvas migran hacia el panículo adiposo (mas profundamente), formando nódulos, subcutáneos migratorios, edema y eosinofilia. Los agentes causales que producen esta variante son:
 
- Gnathostoma spinigerum.

- Gnathostoma doloresis.

- Gnathostoma hispidum.
 
LARVA MIGRANS VISCERAL: 
 
Hay otra variante de la LARVA MIGRANS QUE ES LA VISCERAL (PROFUNDA) causada por otros parásitos como el Toxocara canis (Perro) y otros mas, donde el el parásito "migra: a órganos profundos como: CAVIDAD VISCERAL OJO, CEREBRO, MÚSCULOS Y OTROS. esta es más peligrosa y puede dejar secuelas si no es detectada y tratada a tiempo. 
 
AGENTES CAUSANTES DE LARVA MIGRANS VISCERAL:
 
- Toxocara canis (perros)
 
- Toxocara cati (gatos) 
 
TRATAMIENTOS DE LA LARVA MIGRANS:
 
1.) Ivermectina:

Dosis: 200 mcg/kg (0.2 mg/kg) en dosis única (puede repetirse a los 7-14 días si persisten lesiones), para un adulto de 60 kg le corresponderían 2 pastillas de 6 mgr de ivermectin, que es la presentación original. Considerado actualmente el tratamiento mas eficaz.

2.)  Albendazol: 
 
 La dosis es de 400 mgr dia por 3 a 4 dias seguidos. Se recomienda repetir a la semana 3  o 4 dias mas. Tratamiento muy útil en los niños, pues la presentación es también en suspension, aparte de las tabletas que son de 200 mgr.

3.) Tiabendazol: (drofen): 
 
Dosis 25 mg/kg dia, por 2-5 dias (promedio 3 dias). No disponible en Venezuela hoy dia.

TRATAMIENTO LOCAL:
 
- Criocirugia: (casi en desuso por ser muy dolorosa), consiste aplicar "nitrógeno liquido" desde afuera en el trayecto de la lesion, la larva muere por "enfriamiento".
 
- Formulas magistrales: que contienen albendazol o tinidazol para ser aplicadas externamente: la absorción percutanea de las misma, "envenena" el parásito y muere. 

TRATAMIENTO SINTOMÁTICO:

- Antibióticos: si hay infección secundaria.
 
- Antihistamínicos orales: Para controlar el prurito que puede ser intenso.
 
- Corticoides topicos: Para disminuir la inflamación y evitar infección secundaria. 
 
El tratamiento de la LARVA MIGRANS PROFUNDA VISCERAL y OCULAR., suele ser mas prolongado, 6 a 18 meses promedio. El tratamiento de la LARVA ocular puede incluir cirugía vitroretiniana, fotocoagulación por láser y medicación para evitar daño ocular.

CONCLUSIONES:

 - Instaurar tratamiento temprano para evitar secuelas organicas, principalmente en los casos VISCERALES y OCULARES.
 
- La LARVA MIGRANS CUTANEA, clásica es relativamente fácil de identificar y los tratamientos propuestos son altamente efectivos. 

- De modo pues que cuiden las lindas mascotas, llévenlas regularmente al veterinario y tengan cuidado cuando vayan a la playa y el campo para evitar esta enfermedad. 
 
 En las referencias conocerás la enfermedad y sus variantes, los agentes causales y las opciones terapéuticas

En el attach: la larva, el niño, la mascota, y otras más.  

Larva migrans in two babies and adult foot
 

Saludos a todos !!! 

Dr. José Lapenta
Dr. José M. Lapenta




EDITORIAL ENGLISH 
===================
Hello friends of to the net, DERMAGIC again with you. Today's topic THE CUTANEOUS LARVA MIGRANS SYNDROME AND PETS (DOGS AND CATS).  
 
We love pets, mainly the dogs and cats. But in  the feces (poop) of these beautiful animals there are some parasites  that can pass to the skin when we touch or ingest them. 

The favorite site to contract them is the BEACH or THE FIELD  where  our pretty pets make its  feces. Then we come and frankly we put some part of our body (mainly the foot) in contact with them, and the larva penetrates our skin directly from the feces causing the disease.

Also in homes where there are dogs and cats not controlled by the veterinarian. In short another disease where the man is accidentally contaminated by the animal.
Larva migrans cutanea pie.


Nowadays described in some publications as "the souvenir of travelers and tourists" who contract it during their vacations. Several parasites are the causal agents but the most common are: ANCYLOSTOMA CANNINUM and ANCYLOSTOMA BRAZILIENZE.

OTHER CAUSING AGENTS:

- Ancylostoma ceylanicum, A. tubaeforme (dogs and cats)

- Gnathostoma spinigerum (cats, dogs, pigs)

- Hookworm (dogs in Europe)

- Bunostomum phlebotomum (cattle)

- Pelodera strongyloides

- In rare cases, Ancylostoma duodenale, Necator americanus (human hookworms), and strongyloides stercoralis.


The  cutaneous larva migrans, is a superficial disease, the parasite lives in the superficial layer of the skin, making tunnels as it grows, also called "creeping eruption", but it is self-limited and with a good treatment disappears without leaving complications in the majority of cases.

CUTANEOUS LARVA MIGRANS presents a variant called MIGRATORY NODULAR PANICULITIS: it occurs when the larvae migrate deeper into the fat pad, forming migratory subcutaneous nodules, edema, and eosinophilia. The causative agents that produce this variant are:

- Gnathostoma spinigerum.

- Gnathostoma doloris.

- Gnathostoma hispidum.

VISCERAL LARVA MIGRANS:

There is another variant of LARVA MIGRANS, VISCERAL (DEEP) caused by other parasites such as Toxocara canis (dogs) and others. The parasite migrates to deep organs such as the VISCERAL CAVITY, EYES, BRAIN, MUSCLES, and others. This is more dangerous and can leave after-effects if not detected and treated promptly.

CAUSING AGENTS OF VISCERAL LARVA MIGRANS:

- Toxocara canis (dogs)

- Toxocara cati (cats)

LARVA MIGRANS TREATMENTS:

1.) Ivermectin:

Dose: 200 mcg/kg (0.2 mg/kg) as a single dose (can be repeated after 7-14 days if lesions persist). For a 60 kg adult, the dose would be: Two 6 mg ivermectin tablets, which is the original formulation. Currently considered the most effective treatment.

2.) Albendazole: 
 
The dose is 400 mg daily for 3 to 4 consecutive days. It is recommended to repeat the treatment for 3 or 4 more days a week. This treatment is very useful in children, as it also comes in suspension form, in addition to the 200 mg tablets.

3.) Thiabendazole (Drofen): 
 
Dosage: 25 mg/kg daily, for 2-5 days (average: 3 days). Not currently available in Venezuela.

LOCAL TREATMENT:

- Cryosurgery: (almost obsolete due to its very painful nature), consists of applying "liquid nitrogen" from the outside to the lesion. The larva dies due to "cooling."

- Magistral formulations: containing albendazole or tinidazole for external application: percutaneous absorption of the It "poisons" the parasite, and it dies.

SYMPTOMATIC TREATMENT:

- Antibiotics: if there is a secondary infection.

- Oral antihistamines: To control itching, which can be intense.

- Topical corticosteroids: To reduce inflammation and prevent secondary infection.

Treatment for deep VISCERAL and OCULAR larva migrans is usually longer, averaging 6 to 18 months. Treatment for ocular larva migrans may include vitroretinal surgery, laser photocoagulation, and medication to prevent eye damage.

CONCLUSIONS:

- Establish early treatment to avoid organic sequelae, especially in visceral and ocular cases.

- Classical cutaneous larva migrans is relatively easy to identify, and the proposed treatments are highly effective.

- So, take care of your lovely pets, take them to the vet regularly, and be careful when go to the beach and the countryside to avoid this disease.

So take care of the cute pets, take them regularly to the veterinarian and be careful when go to the beach and the countryside or field to avoid this disease!

In the references you will know the disease and its variants, the causal agents and the therapeutic options

In the attach: the larva, the boy, the pett, and others.



Larva Migrans niña, niño y pie de adulto


Greetings to all.

Dr. José Lapenta
Dr. José M. Lapenta





================================================================
REFERENCIAS BIBLIOGRAFICAS / BIBLIOGRAPHICAL REFERENCES 
================================================================

============================================================ 
0.) CUTANEOUS, VISCERAL and OCULAR LARVA MIGRANS 
============================================================ 
1.) Souvenir from the Hamptons - a case of cutaneous larva migrans of  six  months' duration. 
2.) Effectiveness of a new therapeutic regimen with albendazole in  cutaneous larva migrans. 
3.) [Migrant erythema as clinical presentation of cutaneous larva  migrans  in Mexico City] 
4.) Larva migrans within scalp sebaceous gland. 
5.) Cutaneous larva migrans, sacroileitis, and optic neuritis caused by  an  unidentified organism acquired in Thailand. 
6.) Perianal cutaneous larva migrans in a child. 
7.) [Infections with Baylisascaris procyonis in humans and raccoons] 
8.) Cutaneous larva migrans complicated by erythema multiforme [see  comments] 
9.) Cutaneous larva migrans associated with water shoe use. 
10.) Cutaneous larva migrans infection in the pediatric foot. A review  and  two case reports. 
11.) Creeping eruption of larva migrans--a case report in a beach volley  athlete. 
12.) Albendazole: a new therapeutic regimen in cutaneous larva migrans. 
13.) A primary health care approach to an outbreak of cutaneous larva  migrans. 
14.) Autochthonous cutaneous larva migrans in Germany. 
15.) High prevalence of Ancylostoma spp. infection in dogs, associated  with  endemic focus of human cutaneous larva migrans, in Tacuarembo, Uruguay. 
16.) Persistent cutaneous larva migrans due to Ancylostoma species. 
17.) [A case of Dirofilaria repens migration in man] 
18.) [Cutaneous larva migrans, autochthonous in France. Apropos of a  case] 
19.) Cutaneous larva migrans in travelers: synopsis of histories,  symptoms,  and treatment of 98 patients. 
20.) [Nematode larva migrans. On two cases of filarial infection] 
21.) Larva migrans that affect the mouth. 
22.) Immunological studies on human larval toxocarosis. 
23.) [Larva migrans] 
24.) Effect of albendazole on Ancylostoma caninum larvae migrating in  the  muscles of mice. 
25.) [Ocular manifestations of toxocariasis] 
26.) Toxocara infestations in humans: symptomatic course of toxocarosis  correlates significantly with levels of IgE/anti-IgE immune complexes. 
27.) [Long-term observations of ocular toxocariasis in children and  youth] 
28.) [A case of uveitis due to gnathostoma migration into the vitreous  cavity] 
29.) [The ocular form of toxocariasis] 
30.) [Visceral larval migrans (Human toxocariasis) cause of  hypereosinophilia and visceral granulomas in adults] 
31.) Visceral larva migrans syndrome complicated by liver abscess. 
32.) Visceral larva migrans and tropical pyomyositis: a case report. 
33.) [2 cases of toxocariasis (visceral larva migrans)] 
34.) [Visceral larva migrans. A rare cause of eosinophilia in adults] 
35.) [Visceral larva migrans: a mixed form of presentation in an adult.  The  clinical and laboratory aspects] 
36.) Visceral larva migrans induced eosinophilic cardiac pseudotumor: a  cause of sudden death in a child. 
37.) [Toxocariasis. A cosmopolitan parasitic zoonosis] 
38.) Visceral larva migrans mimicking rheumatic diseases. 
39.) Hepatic granulomas due to visceral larva migrans in adults:  appearance on US and MRI. 
40.) [Ascaridiasis zoonoses: visceral larva migrans syndromes] 
41.) Hepatic visceral larva migrans: evolution of the lesion, diagnosis,  and role of high-dose albendazole therapy. 
42.) Neuroimaging studies of cerebral "visceral larva migrans" syndrome.  43.)[Acute eosinophilic pneumonia and the larva migrans syndrome:  apropos  of a case in an adult] 
44.)Toxocariasis simulating hepatic recurrence in a patient with Wilms'  tumor. 
45.) Hepatic imaging studies on patients with visceral larva migrans due  to  probable Ascaris suum infection. 
46.) Encephalopathy caused by visceral larva migrans due to Ascaris  suum. 
47.) [Imported skin diseases (see comments)] 
48.) [Incidence of Toxocara ova--especially ova of visceral larva  migrans 
in beach sand of Warnemunde in 1997] 
49.) Pets and Parasites. 
50.) Cutaneous larva migrans in travelers: synopsis of histories, symptoms,  and treatment of 98 patients. 
51.) Cutaneous larva migrans. 
52.)[Current therapeutic possibilities in cutaneous larva migrans] 
53.) Cutaneous larva migrans due to Pelodera strongyloides. 
54.) Oral albendazole for the treatment of cutaneous larva migrans. 
55.) Cutaneous larva migrans in northern climates. A souvenir of your  dream  vacation. 
56.) Creeping eruption. A review of clinical presentation and management of 
60 cases presenting to a tropical disease unit. 
57.) Dermatoses associated with travel to tropical countries: a  prospective  study of the diagnosis and management of 269 patients presenting to a  tropical disease unit. 
58.) Larva currens and systemic disease. 
59.) Hookworm folliculitis. 
60.) [Prurigo and further diagnostically significant skin symptoms in  strongyloidosis] 
61.) Gnathostomiasis, or larva migrans profundus. 
62.) Visceral larva migrans caused by Trichuris vulpis. 
63.) Creeping disease due to larva of spiruroid nematoda. 
64.) Creeping eruption due to larvae of the suborder Spirurina--a newly 
recognized causative parasite. 
65.) Linear lichen planus mimicking creeping eruption. 
66.) Diagnosis and management of Baylisascaris procyonis infection in an  infant with nonfatal meningoencephalitis. 
67.) [Human gnathostomiasis. The first evidence of the parasite in South  America] 
68.) Efficacy of ivermectin in the therapy of cutaneous larva migrans 
[letter] 
69.) Hookworm-related cutaneous larva migrans in northern Brazil: resolution of clinical pathology after a single dose of ivermectin.
70.) session of carbon dioxide laser: a study of 0.1111/jocd.12296. [Epub ahead of print]
ten cases in the Philippines.
71.) Treatment of 18 children with scabies or cutaneous larva migrans using ivermectin.
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