UNDERSTANDING THE LYME DISEASE, CLASSIFICATION AND CODES. / LOS CODIGOS DE LA ENFERMEDAD DE LYME - DERMAGIC EXPRESS / Dermatologia y Bibliografia - Dermatology & bibliography DERMAGIC EXPRESS / Dermatologia y Bibliografia - Dermatology & bibliography: UNDERSTANDING THE LYME DISEASE, CLASSIFICATION AND CODES. / LOS CODIGOS DE LA ENFERMEDAD DE LYME

sábado, 16 de diciembre de 2017

UNDERSTANDING THE LYME DISEASE, CLASSIFICATION AND CODES. / LOS CODIGOS DE LA ENFERMEDAD DE LYME


  LYME DISEASE, CLASSIFICATION AND CODES.

ENFERMEDAD DE LYME, CLASIFICACION Y CODIGOS.












EDITORIAL ENGLISH
=================
Hello friends of the network DERMAGIC brings you today another interesting topic about the very well known ERYTHEMA MIGRANS or LYME DISEASE, transmitted by the bite of a TICK, of the IXODES genus being the causal agent an ESPIROCHETE, well known as BORRELIA BURDORGFERI, described for the first time by WILLY BURGDORFER in the year 1.981, and previously known as LYME ARTHRITIS. Today I bring you THE CODES OF LYME'S DISEASE.

 Currently worldwide LYME DISEASE has become a major public health problem, due to the annual increase in cases, which in the United States amounts to about 380,000, new cases annually 2 times more than breast cancer and 6 times more than AIDS, and beyond this, the lack of modernization of the DISEASE CODES at the SOFTWARE or DIGITAL level
them do not appear currently and they need to be recognized so that patients to be and treated in time.  

The events that I present below they are highly related to this lack of "CODIFICATION" of the LYME DISEASE and its different ways of manifesting itself clinically:
 
1.) DIFFICULTY TO MAKE THE DIAGNOSIS:

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It is well known that some TEST, to diagnose the disease, result in "NEGATIVE" due to the ability of the causative agent, the spirochaete BORRELIA to "hide (BIOFILM) before the diagnostic tests." Many patients with symptoms of different diseases such as MENINGITIS , ARTHRITIS, and RECURRENT FEVER, in late stages it is discovered that they are LYME "POSITIVE" after having multiple tests for the diagnosis, losing a VALUABLE TIME to initiate an adequate treatment, and the worse thing is that the chronic development of these symptoms, impar the quality of life of patients who are unattended because they do not have a SPECIFIC DIAGNOSIS.

2.) RESISTANCE TO CONVENTIONAL TREATMENT:

==============================================================================
Another aspect to consider is that BORRELIA and its species over time have developed a "GREAT RESISTANCE" to conventional therapy with the usual antibiotic treatments: MINOCYCLINE, DOXICYCLINE, AMOXICILLIN, CEFUROXIME, and many OTHERS, leading patients to the despair at the occurrence of the codification of the symptoms. LYME DISEASE has FOUR STAGES CLASSICALLY known: INITIAL (I), SECONDARY (II), LATE (III) AND CHRONIC (IV).

3.) THE LACK OF MODERNIZATION OF THE CODES FOR THE LYME DISEASE:

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In this modern and GLOBALIZED world, digitalization and information technology have become essential elements and everything or almost everything HAS A CODE, even DISEASES at the software level, and in the case of LYME DISEASE these must be UPDATED, and this is done based on the EVIDENCE REPORTS, STUDIES AND PUBLICATIONS of the different manifestations of the disease.

Then you will be asking why the LYME DISEASE needs the update of its CODES? If you enter in the World Health Organization (WHO) and look for LYME DISEASE, you will only find TWO (2) mentions in the subject ZOONOSES, transmission by TICKS: LYME DISEASE and RECURRENT FEVER (BORRELIOSIS), and the latest relevant reports  in terms of studies of the disease by WHO date from the years 1,993 and 1,995:

1.) WHO Workshop on Diagnosis and Surveillance of Lyme Borreliosis. Warsaw, Poland, 20-22 June 1995, Ref.: WHO / CDS / VPH / 95.141:
The countries involved were: Austria, Bulgaria, Czech Republic, Denmark, Yugoslavia, France, Hungary, Ireland, Japan, Holland, Poland, Russia, Sweden, Switzerland, United Kingdom and the United States.
2.) Report of a WHO Workshop on Lyme Borreliosis. Piestany, Slovak Republic, 6 October 1993, Ref: WHO / CDS / VPH / 93.132:

The countries involved: Germany, Slovakia and the United States. If you read those reports you will notice that they are TOTALLY OUT OF DATE regarding the REALITY of LYME DISEASE today.

And I will always give you the answer.

I will place here more than 270 BIBLIOGRAPHY REFERENCES classified based on the different manifestations of LYME DISEASE or LYME BORRELIOSIS that are sufficient to RECOGNIZE that beyond "LYME DISEASE" AND "RECURRENT FEVER (BORRELIOSIS) there are other manifestations of the BORRELIOSIS that should be CODIFIED, DIGITALIZED, to give a total coverage to the DISEASE and search of its clinical manifestations.

This "ABSENCE" of CODES causes that many patients carrying LYME are not treated ADEQUATELY, because they DO NOT "APPEAR IN THE SYSTEM" with their respective consequences.

Here I ask the INNOCENT question, what happens is "UNKNOWN" or "INTENTIONED"? because to recognize all these IMPLIED CODES means more public spending by the State and the insurance companies.

1.) CONGENITAL LYME DISEASE: Potential infection of the fetus with possibility of death:

- LYME BORRELIOSIS IN PREGNANT WOMEN.
- ERLICHIOSIS AND BORRELIOSIS IN PREGNANT WOMEN.
- THE INFECTIOUS ORIGINS OF STILLBIRTH.
- INTRAUTERINE TRANSMISSION OF BORRELIA BURGDORFERI IN DOGS.

2.) LYME DISEASE: PRIMARY INFECTION:


- NEWBORN DEAD WOMAN PREGNANT WITH LYME DISEASE.
- LYME BBORRELIOSIS, IMPLICATION FOR THE FETUS.
- FETAL BORRELIOSIS, TEXEMIA OF PREGNANCY AND FETAL DEATH.
- ERITEMA MIGRANS IN PREGNANCY.
- FETAL MATERNAL TRANSMISSION OF LYME DISEASE.
- BORRELIA BURDOGFERI IN NEWBORN.

A.) PRIMARY INFECTION AND ERYTHEMA MIGRANS.


-  PRIMARY AND SECONDARY ERYTHEMA MIGRANS.

B.) PRIMARY SERONEGATIVE INFECTION.


- NEGATIVE ANTIGENS AGAINST BORRELIA BURGDORFERI IN CEREBOSPINAL FLUID IN NEUROLOGIC LYME DISEASE.
- SERONEGATIVE LYME DISEASE.
- SERONEGATIVE CHRONIC RELAPSING  NEUROBORRELIOSIS.

3.) LYME DISEASE, PERSISTENT INFECTION IN SECONDARY AND LATE STAGE

- PERSISTENT INFECTION WITH ANTIBIOTICS DOXYCYLINE AND AMOXICILLIN.
- ISOLATION OF BORRELIA BURGDORFERI FROM OCULAR IRIS.
- SURVIVAL OF BORRELIA BURGDORFERI AFTER THERAPY WITH ANTIBIOTIC.

4.) LYME DISEASE, PERSISTENT INFECTION IN SECONDARY AND LATE STAGE:

A.) CUTANEOUS MANIFESTATIONS:

- BORRELIAL LYMPHOCYTOMA  (BL).
- ACRODERMATITIS ATROPHICANS.
- ANNULARE GRANULOMA.
- MORPHEA.
- LOCALIZED SCLERODERMA.
- LICHEN SCLEROSUS AND ATROPHICUS.

B.) OTHER CUTANEOUS MANIFESTATIONS:

- BENIGN LYMPHOCYTIC INFILTRATION OF JESSNER KANOF.
- INFANTILE ACRODERMATITIS OF GIANOTTI-CROSTI.
- ATYPICAL ERYTHEMA MULTIFORME.
- URTICARIAL VASCULITIS.

5.) LYME DISEASE OF SKIN AND MUCOUS MEMBRANES:


- ASSOCIATION OF LYME DISEASE WITH MORGELLONS DISEASE.
- DIFUSSE ALOPECIA.
- SCLERODERMA IN CUP  DE SABRE.
- PSEUDOPELADE OF BROCQ.

6.) LYME DISEASE AND OTHER LESIONS:


- ANETODERMA.
- PRIMARY AND SECONDARY ERYTHEMA MIGRANS IN CHILDREN.

7.) LYME DISEASE LATE STAGE: MENINGITIS, OCULOPATHY, IRIDOCYCLITIS, IRITIS,UVEITIS.

 
A.) LYME MENINGITIS.
B.) LYME OCULOPATHY.
C.) LYME IRIDOCYCLITIS, IRITIS AND UVEITIS.


8.) LYME DISEASE SECONDARY AND LATE STAGE: NEPHRITIS, HEPATITIS, LYMPHADENOPATHY, MYOSITIS AND OTHER.

A.) LYME NEPHRITIS.
B.) LYME HEPATITIS.
C.) LYME LYMPHADENOPATHY.
D.) LYME MYOSITIS.
E.) OTHER CONDITIONS:


- PERPLEXING  SYMPTOMS.
- PANCYTOPENIA.
- EYE SYMPTOMS.

9.) .) LYME DISEASE LATE STAGE AND CARDIOVASCULARY DISEASE.

A.) AORTIC ANEURYSM.
B.) ANEURYSM OF CORONARY ARTERIES.
C.) LATE ENDOCARDITIS.
D.) CARDITIS.
E.) ATRIOVENTRICULAR BLOCK.


10.) LYME DISEASE LATE STAGE, NEURO-BORRELIOSIS, NEURITIS OR NEUROPATHY, MENINGOVASCULAR, NB WITH CEREBRAL INFARCTS, LYME PARKINSONISM, LYME ENCEPHALITIS.

 
A.) NEUROBORRELIOSIS (NB) LATE SYMPTOMS.
B.) NEURITIS OR LATE NEUROPATHY.
C.) NEUROBORRELIOSIS (NB) MENINGOVASCULAR WITH CEREBRAL INFARCTS.
D.) INTRACRANEAL ANEURYSM.
E.) PARKINSONISM.
F.) LATE ENCEPHALITIS.
G.) STROKE DUE TO NEUROBORRELIOSIS.
H.) NEUROBORRELIOSIS (NB) UNSPECIFIC SYMPTOMS:


- LATE LYME DISEASE (NEUROBORRELIOSIS: COMPARISON AND EVIDENCE OF THE SPIROCHETES AND LATE NEUROSYPHILIS.
- EVIDENCE BETWEEN THE INFECTION OF SPIROCHETES AND ALZHEIMER'S DISEASE.

11.) LYME DISEASE: NEUROBORRELIOSIS, LATE LYME MENINGOENCEPHALITIS OR MENINGOMYELOENCEPHALITIS.

 
12.) LYME DISEASE LATE STAGE: ATROPHIC FORM OF MENINGOENCEPHALITIS WITH DEMENTIA, SUBACUTE PRESENILE  DEMENTIA AND NEUROPSYCHIATRIC MANIFESTATIONS.


13.) LYME DISEASE: LATE STAGE: BONE, JOINT AND MUSCULOSKELETAL MANIFESTATIONS

14.) LYME DISEASE, LATE STAGE: OCULOPATHY, LIVER, KIDNEY AND RESPIRATORY MANIFESTATIONS.


A.) OCULOPATHY.
B.) LIVER AND OTHER VISCERAS.
C.) KIDNEY AND URETER.
D.) BRONCHIA AND LUNGS.

 
15.) LYME DISEASE, LATENT STAGE, UNESPICIFIED

A.) INFECTION OF THE CENTRAL NERVOUS SYSTEM.
B.) SIMPLE HERPES TYPE 1.
C.) DISEASES BY SPIROCHETES OF THE CENTRAL NERVOUS SYSTEM.
 


This CLASSIFICATION that you have just read is a summary of the 280 BIBLIOGRAPHIC REFRENCES that I describe below which you can find in the best scientific DATABASES such as PUBMED, MEDSCAPE, LILACS etc, if you have some doubt COPY and PASTE of any of them, put it in your browser and you will get the EXACT information on the mentioned DATABASES.

As you can see, there are enough EVIDENCES, to UPDATE the CODES OF LYME DISEASE in all the DATABASES systems of the PLANET, to give a TOTAL coverage to the diagnosis and treatment of this disease that in my particular way of seeing is becoming the NEW PLAGUE OF THE 21ST CENTURY.


Read here the second chapter of:



But this does not end here, suddenly you think that some details are missing, some or several questions, which I will explain in the 

NEXT EDITION: LYME'S DISEASE, SYPHILIS AND LEPROSY, THE MISSING LINK.  

DO NOT MISS IT !!!

In the references the facts ...

Greetings to all

Dr. José Lapenta



EDITORIAL ESPAÑOL
=================

Hola amigos de la red DERMAGIC te trae hoy otro tema interesante sobre la muy bien conocida ERITEMA MIGRANS o ENFERMEDAD DE LYME, transmitida por la picadura de una GARRAPATA, del genero IXODES siendo el agente causal una ESPIROQUETA, bien conocida como BORRELIA BURDORGFERI, descrita por primera vez por WILLY BURGDORFER en el año 1.981,  y previamente conocida como ARTRITIS DE LYME. Hoy te traigo LOS CODIGOS DE LA ENFERMEDAD DE LYME.

 Actualmente  a nivel mundial la ENFERMEDAD DE LYME se ha convertido en un gran problema de salud pública, debido al aumento anual de los casos, que en los Estados unidos asciende a unos 380.000, casos nuevos anuales, 2 veces más que el cáncer  de mama y 6 veces más que el SIDA, y mas allá de esto, la falta de modernización de los CODIGOS DE LA ENFERMEDAD a nivel de SOFTWARE o DIGITAL, Estos no aparecen actualmente y deben ser reconocidos para que los pacientes puedan ser tratadosr a tiempo.

Los eventos que presento a continuación están altamente relacionados con esta falta de "CODIFICACIÓN" de la ENFERMEDAD DE LYME y sus diferentes formas de manifestarse clínicamente:


1.) DIFICULTAD PARA HACER EL DIAGNOSTICO:
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Ya bien es conocido que algunos TEST, para diagnosticar la enfermedad dan como resultado "NEGATIVO" por la habilidad que tiene el agente causal, la espiroqueta BORRELIA de "esconderse (BIOFILM) ante las pruebas diagnosticas. Muchos pacientes con síntomas de diferentes enfermedades como MENINGITIS, ARTRITIS, y  FIEBRE RECURRENTE, en etapas tardías se descubre que son LYME "POSITIVOS" luego de hacerse múltiples pruebas para el diagnostico, perdiéndose un TIEMPO VALIOSO para iniciar un tratamiento adecuado, y lo peor es que el desarrollo crónico de estos síntomas, daa la calidad de vida de los pacientes que son desasistidos por no tener UN DIAGNOSTICO ESPECIFICO.

2.) RESISTENCIA AL TRATAMIENTO CONVENCIONAL:
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Otro de los aspectos a considerar es que la BORRELIA  y sus especies con el tiempo han desarrollado una "GRAN RESISTENCIA" a la terapia convencional con los consabidos tratamientos antibióticos: MINOCICLINA, DOXICICLINA, AMOXICILINA, CEFUROXIMA, y OTROS, llevando a los pacientes a la desesperación al producirse la cronificación de los síntomas.  La ENFERMEDAD DE LYME tiene CUATRO ETAPAS CLASICAMENTE conocidas: INICIAL (I), SECUNDARIA (II), TARDIA (III) Y CRONICA (IV).

3.) LA FALTA DE MODERNIZACION DE LOS CODIGOS PARA LA ENFERMEDAD DE LYME:
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En este mundo moderno y GLOBALIZADO, la digitalización y la informática se han convertido en elementos esenciales y todo o casi todo TIENE UN CODIGO, aun las ENFERMEDADES a nivel de software, y en el caso de la ENFERMEDAD DE LYME estos deben ser ACTUALIZADOS, y esto se hace en base a las EVIDENCIAS REPORTES, ESTUDIOS Y PUBLICACIONES de las distintas manifestaciones de la enfermedad.

Entonces te estarás preguntando porque la ENFERMEDAD DE LYME necesita la actualización de sus CODIGOS? Si tú te metes en la Organización Mundial de La Salud (WHO) y buscas LA ENFERMEDAD DE LYME, solo encontraras DOS (2) menciones en el tema ZOONOSIS, transmisión por GARRAPATAS: LYME DISEASE y FIEBRE RECURRENTE (BORRELIOSIS), y los últimos reportes relevantes en cuanto a  estudios de la enfermedad por la OMS  datan de los años 1.993 y 1.995:

1.) WHO Workshop on Lyme Borreliosis Diagnosis and Surveillance. Warsaw, Poland, 20-22 June 1995, Ref: WHO/CDS/VPH/95.141:

Los países involucrados fueron: Austria, Bulgaria, Republica Checa, Dinamarca, Yugoslavia, Francia, Hungría, Irlanda, Japón< Holanda, Polonia, Rusia, Suecia, Suiza, Reino Unido y Estados Unidos.

2.) Report of a WHO Workshop on Lyme Borreliosis. Piestany, Slovak Republic, 6 October 1993, Ref: WHO/CDS/VPH/93.132:

Los países involucrados: Alemania, Eslovaquia y Estados Unidos. Si te lees esos reportes podrás notar que están TOTALMENTE DESACTUALIZADOS en cuanto a la REALIDAD de la ENFERMEDAD DE LYME hoy día.

 Y yo como siempre te voy a dar la respuesta:

Te voy a colocar acá mas de 270 REFERENCIAS BIBLIOGRAFICAS clasificadas en base a las distintas manifestaciones de LA ENFERMEDAD DE LYME o LYME BORRELIOSIS que son suficientes para RECONOCER que mas allá de "ENFERMEDAD DE LYME" Y "FIEBRE RECURRENTE (BORRELIOSIS) hay otras manifestaciones de la BORRELIOSIS que deben ser CODIFICADAS, DIGITALIZADAS, para darle una total cobertura a la ENFERMEDAD y búsqueda de sus manifestaciones clínicas. 

Esta "AUSENCIA" de CODIGOS provoca que muchos pacientes portadores de LYME no sean atendidos ADECUADAMENTE, pues NO "APARECEN EN EL SISTEMA" con sus respectivas consecuencias.

Aquí me hago la INOCENTE pregunta, esto que ocurre es "DESCONOCIMIENTO" o "INTENCIONADO"? porque reconocer todos estos CODIGOS IMPLICARIA más gasto publico por parte del Estado y de las compañías de seguros.

Aquí te pongo la CLASIFICACION  y luego las referencias:

1.) ENFERMEDAD DE LYME CONGENITA:  Potencial infección del Feto con posibilidad de Muerte:

- LYME BORRELIOSIS EN MUJER EMBARAZADA.
-  ERLIQUIOSIS Y BORRELIOSIS EN MUJER EMBARAZADA.
-  ORIGEN DE LAS INFECCIONES EN RECIEN NACIDOS MUERTOS.
- TRNASMISION INTRAUTERINA DE BORRELIA BURGDORFERI EN PERROS.

2.) ENFERMEDAD DE LYME: INFECCION PRIMARIA:

-  RECIEN NACIDO MUERTO DE MUJER EMBARAZADA CON ENFERMEDAD DE LYME.
- LYME BBORRELIOSIS, IMPLICACION PARA EL FETO.
- BORRELIOSIS FETAL, TOXEMIA DEL EMBARAZO Y MUERTE FETAL.
- ERITEMA MIGRANS EN EL EMBARAZO.
- TRANSMISION MATERNO FETAL DE LA ENFERMEDAD DE LYME.
- BORRELIA BURDOGFERI EN RECION NACIDO.

A.) INFECCION PRIMARIA Y ERITEMA MIGRANS.

- ERITEMA MIGRANS PRIMARIO Y SECUNDARIO.

B.) INFECCION PRIMARIA SERONEGATIVA.

- ANTIGENOS NEGATIVOS CONTRA BORRELIA BURGDORFERI EN FLUIDO CEREBRO ESPINAL EN ENFERMEDAD DE LYME NEUROLOGICA.
- ENFERMEDAD DE LYME SERONEGATIVA.
- NEUROBORRELIOSIS RECURRENTE CRONICA SERONEGATIVA.

3.) ENFERMEDAD DE LYME: INFECCION PERSISTENTE EN LA ETAPA SECUNDARIA Y TARDIA:

- INFECCION PERSISTENTE A ANTIBIOTICOS DOXIXICLINA Y AMOXICILINA.
- AISLAMIENTO DE BORRELIA BURGDORFERI DE IRIS OCULAR.
- SOBREVIVENCIA DE BORRELIA BURGDORFERI LUEGO DE ANTIBIOTICOTERAPIA.

4.) ENFERMEDAD DE LYME: INFECCION SECUNDARIA Y TARDIA:

A.) MANIFESTACIONES CUTANEAS:

- LINFOCITOMA POR BORRELIA (BL).
- ACRODERMATITIS ATROFICA.
-  GRANULOMA ANULAR.
- MORFEA.
- ESCLERODERMIA LOCALIZADA.
- LIQUEN ESCLEROSO Y ATROFICO.

B.) OTRAS MANIFESTACIONES CUTANEAS:

- INFILTRADO LINFOCITICO BENIGNO  DE JESSNER KANOF.
- ACRODERMATITIS DE GIANOTTI CROSTI.
- ERITEMA MULTIFORME ATIPICO.
- VASCULITIS URTICARIANA.

5.) ENFERMEDAD DE LYME DE LA PIEL Y MEMBRANAS MUCOSAS:

- ASOCIACION DE LA ENFERMEDAD DE LYME CON LA ENFERMEDAD DE MORGELLON.
- ALOPECIA DIFUSA.
- ESCLERODERMIA EN GOLPE DE SABLE.
- PSEUDOPELADA DE BROCQ.

6.) ENFERMEDAD DE LYME: OTRAS LESIONES:

- ANETODERMA.
- ERITEMA MIGRANS PRIMARIO Y SECUNDARIO EN NIÑOS.

7.) ENFERMEDAD DE LYME SECUNDARIA Y TARDIA: MENINGITIS, OCULOPATIA, IRIDOCICLITIS , IRISTIS, UVEITIS.

A.) LYME MENINGITIS.
B.) LYME OCULOPATIA.
C.)  LYME IRIDOCICLITIS, IRITIS Y UVEITIS.

8.) ENFERMEDAD DE LYME: NEFRITIS SECUNDARIA Y TARDIA, HEPATITIS, LINFADENOPATIA, MIOSITIS Y OTRAS.

A.) LYME NEFRITIS.
B.) LYME HEPATITIS.
C.)  LYME LINFADENOPATIA.
D.) LYME MIOSITIS.
E.) OTRAS CONDICIONES:

- SINTOMAS PERPLEJOS.
- PANCITOPENIA.
- SINTOMAS OCULARES.

9.) ENFERMEDAD DE LYME TARDIA: MANIFESTACIONES CARDIOVASCULARES:

A.) ANEURISMA AORTICO.
B.) ANEURISMA DE ARTERIAS CORONARIAS.
C.) ENDOCARDITIS TARDIA.
D.) CARDITIS.
E.) BLOQUEO ATRIOVENTRICULAR.

10.) ENFERMEDAD DE LYME: NEUROBORRELIOSIS TARDIA (NB), NEURITIS O NEUROPATIA, NEUROBORRELIOSIS (NB) CON INFARTOS CEREBRALES, PARKINSONISMO Y  ENCEFALITIS.

A.) NEUROBORRELIOSIS (NJB) TARDIA SINTOMATICA.
B.) NEURITIS O NEUROPATIA TARDIA.
C.) NEUROBORRELIOSIS (NB) MENINGOVASCULAR CON INFARTOS CEREBRALES.
D.) ANEURISMA INTRACRANEANO.
E.)  PARKINSONISMO.
F.) ENCEFALITIS TARDIA.
G.) EMBOLIA POR NEUROBORRELIOSIS.
H.) NEUROBORRELIOSIS (NB) SINTOMAS INESPECIFICOS:

- ENFERMEDAD DE LYME TARDIA (NEUROBORRELIOSIS: COMPARACION Y EVIDENCIA DE LAS ESPIROQUETAS Y LA NEUROSIFILIS TARDIA.
- EVIDENCIAS ENTRE LA INFECCION POR ESPIROQUETAS Y LA ENFERMEDAD DE ALZHEIMER.

11.) ENFERMEDAD DE LYME TARDIA: NEUROBORRELIOSIS, MENINGOENCEFALITIS O MENINGOMIELOENCEFALITIS TARDIA.

12.) ENFERMEDAD DE LYME TARDIA: FORMA ATROFICA DE MENINGOENCEFALITIS CON DEMENCIA Y DEMENCIA SUBAGUDA PRESENIL Y MANIFESTACIONES NEUROSIQUIATRICAS.

13.) ENFERMEDAD DE LYME TARDIA: HUESOS, ARTICULACIONES Y MANIFESTACIONES MUSCULO ESQUELETICAS.

14.) ENFERMEDAD DE LYME TARDIA: OCULOPATIA, HIGADO, RIÑON Y MANIFESTACIONES RESPIRATORIAS.

A.) OCULOPATIA.
B.) HIGADO Y OTRAS VISCERAS.
C.) RIÑON Y URETER.
D.) BRONQUIOS Y PULMONES.

15.) ENFERMEDAD DE LYME LATENTE: SINTOMAS INESPECIFICOS.

A.) INFECCION DEL SISTEMA NERVIOSO CENTRAL.
B.) HERPES SIMPLE TIPO 1.
C.) ENFERMEDADES POR ESPIROQUETAS DEL SISTEMA NERVIOSO CENTRAL.

Esta CLASIFICACION que acabas de leer es un resumen de las 280 REFERENCIAS BIBLIOGRAFICAS  que te describo abajo las cuales puedes encontrar en las mejores BASES DE DATOS cientificas como PUBMED, MEDSCAPE, LILACS etc, si tienes alguna duda has un COPIA y PEGA de cualquiera de ellas,  la colocas en tu navegador y obtendrás la información EXACTA en las mencionadas BASES DE DATOS.

Como podrás ver, existen suficientes EVIDENCIAS, para ACTUALIZAR los CODIGOS DE LA ENFERMEDAD DE LYME en todos los sistemas INFORMATICOS DEL PLANETA, para darle una cobertura TOTAL al diagnostico y tratamiento de esta enfermedad que a mi modo particular de ver se está convirtiendo en la NUEVA PLAGA del SIGLO XXI.

Lee aqui el segundo Capitulo de:



Pero esto no termina aqui, de pronto piensas que faltan algunos detalles, algunas o varias interrogantes, las cuales te voy a explicar en la PROXIMA EDICION:
 
ENFERMEDAD DE LYME, SIFILIS Y LEPRA, EL ESLABON PERDIDO.  


NO TE LA PIERDAS !!!

En las referencias los hechos...

Saludos a Todos.

Dr. jose Lapenta.

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EBIBLIGRAPHICAL REFERENCES / REFERENCIAS BIBLIOGRAFICAS
==============================================================================
1.) CONGENITAL LYME DISEASE / Borrelia burgdorferi can potentially infect the fetus and cause adverse fetal outcomes
==============================================================================
1.) Congenital infections and the nervous system. Pediatric Clinics of North America. 1992;39(4):669–690. doi:10.1016/s0031-3955(16)38370-5. [PubMed] Bale JF, Murph JR.

2.) [Human granulocytic ehrlichiosis co-incident with Lyme borreliosis in pregnant woman--a case study] [in Polish] Przegl Epidemiol. 2004;58(2):289–94. [PubMed] Brzostek T.

3.) Lyme disease. In: Remington JS, Klein JO, eds. Infectious Diseases of the Fetus and Newborn. 5th ed. Philadelphia: Saunders; 1995:447–528chap 11. Gardner T.

4.) Lyme disease. In: Remington JS, Klein JO. Infectious diseases of the fetus and newborn infant. 4th ed. Philadelphia: W B Saunders Co; December 13, 1994. Gardner T.

5.) The infectious origins of stillbirth. American Journal of Obstetrics and Gynecology. 2003;189(3):861–873. doi:10.1067/s0002-9378(03)00470-8. [PubMed] Goldenberg RL, Thompson C.

6.) Intrauterine transmission of Borrelia burgdorferi in dogs. American Journal of Veterinary Research. 1993;54(6):882–890. [PubMed Gustafson JM, Burgess EC, Wachal MD, Steinberg H.

7.) Stillbirth following maternal Lyme disease. N Y State J Med. 1987;11:615–616. [PubMed] MacDonald AB, Benach JL, Burgdorfer W.

8.)  Gestational Lyme borreliosis. Implications for the fetus. Rheum Dis Clin North Am. 1989;15(4):657–677. [PubMed] MacDonald AB.

9.) Human fetal borreliosis, toxemia of pregnancy, and fetal death. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology. 1986;263(1-2):189–200. doi:10.1016/s0176-6724(86)80122-5. [PubMed] Macdonald AB.

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13.) Fetal outcome in Murine Lyme disease. Infection and Immunity. 1995;63(1):66–72. [PubMed] Silver RM, Yang L, Daynes RA, Branch WD, Salafia CM, Weis JJ.

14.) Lyme disease and pregnancy outcome: A prospective s of two thousand prenatal patients. American Journal of Obstetrics and Gynecology. 1993;169(2):367–374. doi:10.1016/0002-9378(93)90088-z. [PubMed] Strobino BA, Williams CL, Abid S, Ghalson R, Spierling P.

15.) Borrelia burgdorferi in a newborn despite oral penicillin for Lyme borreliosis during pregnancy. The Pediatric Infectious Disease Journal. 1988;7(4):286–288. doi:10.1097/00006454-198804000-00010. [PubMed]
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17.)  Contributions to the treatment of dermatologic manifestations of Lyme borreliosis. Cutis. 1992 Jun;49(6):409-11. [PubMed] Hercogová J, Tománková M, Barták P.

18.) Study Group for Lyme Borreliosis. Disease expression of Lyme borreliosis in northeastern France. Eur J Clin Microbiol Infect Dis. 2001;20(4):225-30. [PubMed] Lipsker D, Hansmann Y, Limbach F, Clerc C, Tranchant C, Grunenberger F, Caro-Sampara F, Attali P, Frey M, Kubina M, Piémont Y, Sibilia J, Jaulhac B; GEBLY Study Group.

19.) Primary and secondary erythema migrans in central Wisconsin. Arch Dermatol. 1993;129(6):709-16. [PubMed] Melski JW, Reed KD, Mitchell PD, Barth GD.

20.) Epidemiology and clinical similarities of human spirochetal diseases. Rev Infect Dis. 1989;11Suppl 6:S1460-9. Review type. [PubMed] Schmid GP.
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22.) Detection of Borrelia burgdorferi-specific antigen in antibody-negative cerebrospinal fluid in neurologic Lyme disease. Neurology. 1995;45(11):2010–2015. [PubMed]Coyle PK, Schutzer SE, Deng Z, et al.

23.) Seronegative Lyme Disease. Dissociation of T- and B-Lymphocyte Responses to Borrelia burgdorferi. N Engl J Med 1988;319:1441-6.
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24.) Tick inoculation in an eyelid region: report on five cases with one complication of the orbital myositis associated with Lyme borreliosis. Klin Oczna. 2006;108(4-6):220-4. [PubMed] Holak H1, Holak N, Huzarska M, Holak S.

25.) Diagnosis and clinical characteristics of ocular Lyme borreliosis. Am J Ophthalmol. 1995;119(2):127-35. [PubMed]Karma A, Seppälä I, Mikkilä H, Kaakkola S, Viljanen M, Tarkkanen A.

26.) Seronegative Chronic Relapsing Neuroborreliosis. Eur Neurol 1995;35:113-117. [PubMed] Lawrence C, Lipton RB, Lowy FD, Coyle PK.
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27.) Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library. Emerg. Microbes Infect. 2014;3:e49. doi: 10.1038/emi.2014.53. [PMC free article] [PubMed] [Cross Ref] Feng J., Wang T., Shi W., Zhang S., Sullivan D., Auwaerter P.G., Zhang Y.

28.) Borrelia burgdorferi detected by culture and PCR in clinical relapse of disseminated Lyme borreliosis. Ann. Med. 1999;31:225–232. doi: 10.3109/07853899909115982. [PubMed] [Cross Ref] Oksi J., Marjamaki M., Nikoskelainen J., Viljanen M.K.

29.) First Isolation of Borrelia burgdorferi from an Iris Biopsy. J Clin Neuro-ophthalmol 1993;13:155-161. [PubMed]
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30.) Cultivation of Borrelia burgdorferi from joint fluid three months after treatment of facial palsy due to Lyme borreliosis. J. Infect. Dis. 1988;158:905–906. doi: 10.1093/infdis/158.4.905. [PubMed] [Cross Ref  Schmidli J., Hunziker T., Moesli P., Schaad U.B.
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31.) Borrelial Lymphocytoma in Children. Pediatr Infect Dis J. 2015;34(12):1319-22. [PubMed] Arnež M, Ružic-Sabljic E.

32.) Borrelia burgdorferi-associated lymphocytoma cutis: clinicopathologic, immunophenotypic, and molecular study of 106 cases. J Cutan Pathol. 2004;31(3):232-40. [PubMed] Colli C, Leinweber B, Müllegger R, Chott A, Kerl H, Cerroni L.

33.) Clinical spectrum of skin manifestations of Lyme borreliosis in 204 children in Austria. Acta Derm Venereol. 2015;95(5):565-71. [PubMed] Glatz M, Resinger A, Semmelweis K, Ambros-Rudolph CM, Müllegger RR.

34.) B.Borrelia burgdorferi infection and cutaneous Lyme disease, Mexico. Emerg Infect Dis. 2007;13(10):1556-8. [PubMed]  Gordillo-Pérez G, Torres J, Solórzano-Santos F, de Martino S, Lipsker D, Velázquez E, Ramon G, Onofre M, Jaulhac

35.) Therapy of Lyme borreliosis in children. Infection. 1996;24(2):170-3. [PubMed]MKrbkova L, Stanek G.

36.) Species of Borrelia burgdorferi complex that cause borrelial lymphocytoma in France. Br J Dermatol. 2009;161(1):174-6. [PubMed]
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37.) Solitary borrelial lymphocytoma in adult patients. Wien Klin Wochenschr. 2002;114(13-14):515-23. [PubMed] Maraspin V, Cimperman J, Lotric-Furlan S, Ruzic-Sabljic E, Jurca T, Picken RN, Strle F.

38.) Borrelial Lymphocytoma in Adult Patients. Clin Infect Dis. 2016;63(7):914-21. [PubMed] Maraspin V, Nahtigal Klevišar M, Ružic-Sabljic E, Lusa L, Strle F.

39.) Chemokine signatures in the skin disorders of Lyme borreliosis in Europe: predominance of CXCL9 and CXCL10 in erythema migrans and acrodermatitis and CXCL13 in lymphocytoma. Infect Immun. 2007;75(9):4621-8. [PubMed]  Müllegger RR, Means TK, Shin JJ, Lee M, Jones KL, Glickstein LJ, Luster AD, Steere AC.

40.) Treatment of borrelial lymphocytoma. Infection. 1996;24(1):80-4. [PubMed] Strle F, Maraspin V, Pleterski-Rigler D, Lotric-Furlan S, Ruzic-Sabljic E, Jurca T, Cimperman J. 
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LYME DISEASE AND ACRODERMATITIS ATROPHICANS
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42.) Borrelia burgdorferi sensu lato strains isolated from cutaneous Lyme borreliosis biopsies differentiated by pulsed-field gel electrophoresis. Scand J Infect Dis. 1996;28(6):583-9. [PubMed] Busch U, Hizo-Teufel C, Böhmer R, Fingerle V, Rössler D, Wilske B, Preac-Mursic V.

43.) Further evidence for Borrelia burgdorferi infection in morphea and lichen sclerosus et atrophicus confirmed by DNA amplification. J Invest Dermatol. 1993;100(5):717-20. [PubMed] Schempp C, Bocklage H, Lange R, Kölmel HW, Orfanos CE, Gollnick H.

44.) Molecular subtyping of Borrelia burgdorferi in erythema migrans and acrodermatitis chronica atrophicans. J Invest Dermatol. 1994;103(1):19-22. [PubMed] Wienecke R1, Zöchling N, Neubert U, Schlüpen EM, Meurer M, Volkenandt M.

45.) Acrodermatitis chronica atrophicans--a spirochetosis. Clinical and histopathological picture based on 32 patients; course and relationship to erythema chronicum migrans Afzelius. Am J Dermatopathol. 1986;8(3):209-19. [PubMed]  Asbrink E, Brehmer-Andersson E, Hovmark A.

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47.)Localized scleroderma associated with Borrelia burgdorferi infection. Clinical, histologic, and immunohistochemical observations. J Am Acad Dermatol. 1993;29(2 Pt 1):190-6. [PubMed] Buechner SA, Winkelmann RK, Lautenschlager S, Gilli L, Rufli T.

48.) Morphoea: a manifestation of infection with Borrelia species? Br J Dermatol. 2007;157(6):1189-98. [PubMed] Eisendle K, Grabner T, Zelger B.

49.) Chronic borreliosis presenting with morphea- and lichen sclerosus et atrophicus-like cutaneous lesions. a case report. Dermatology. 2001;202(4):373-5. [PubMed] Kaya G, Berset M, Prins C, Chavaz P, Saurat JH.

50.) Diagnosis of Lyme disease based on dermatologic manifestations. Ann Intern Med. 1991;114(6):490-8. [PubMed]  Malane MS, Grant-Kels JM, Feder HM Jr, Luger SW.

51.) Eruzione a tipo pitiriasi lichenoide con perifollicoliti in corso di borreliosi di Lyme. Eur J Pediat Dermatol. 1994;4:77–80. Menni S, Pistritto G, Gelmetti C, Stanta G, Trevisan G.

52.) Evidence for Borrelia burgdorferi in morphea and lichen sclerosus. Int J Dermatol. 2000;39(4):278-83. [PubMed] Ozkan S, Atabey N, Fetil E, Erkizan V, Günes AT.

53.)  Further evidence for Borrelia burgdorferi infection in morphea and lichen sclerosus et atrophicus confirmed by DNA amplification. J Invest Dermatol. 1993;100(5):717-20. [PubMed] Schempp C, Bocklage H, Lange R, Kölmel HW, Orfanos CE, Gollnick H.

54.) Morphea Borrelia burgdorferi and localized scleroderma. Clin Dermatol. 1994;12(3):475-9. [ScienceDirect]  Trevisan G, Rees DH, Stinco G.

55.) Lyme Borreliosis and Skin. Indian J Dermatol. 2013;58(3): 167–174. doi: 10.4103/0019-5154.110822 [PubMed] Vasudevan B, Chatterjee M.

56.) Extragenital lichen sclerosus with aetiological link to Borrelia. MJAFI. 2011;67:370–3. [PubMed] Vasudevan B, Sagar A, Bahal A, Mohanty AP.

57.) Is Localized Scleroderma Caused by Borrelia burgdorferi? Vector Borne Zoonotic Dis. 2016;16(9):577-80. [PubMed]Zinchuk AN, Kalyuzhna LD, Pasichna IA.
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58.) Benign lymphocytic infiltration (Jessner-Kanof): another manifestation of borreliosis? J Am Acad Dermatol. 1989;21(4 Pt 1):795-7. [PubMed] Abele DC, Anders KH, Chandler FW.

59.) Infantile acrodermatitis of Gianotti-Crosti and Lyme borreliosis. Acta Derm Venereol. 1996;76(3):242-3. [PubMed]Baldari U, Cattonar P, Nobile C, Celli B, Righini MG, Trevisan G.

60.) Polymerase chain reaction of Borrelia burgdorferi flagellin gene in Shulman syndrome. Dermatology. 1996;192(2):136-9. [PubMed] Hashimoto Y, Takahashi H, Matsuo S, Hirai K, Takemori N, Nakao M, Miyamoto K, Iizuka H.

61.) Atypical erythema multiforme occurring at the early phase of Lyme disease? Acta Derm Venereol. 2000;80(3):222. [PubMed] Lesire V, Machet L, Toledano C, de Muret A, Maillard H, Lorette G, Vaillant L.

62.) Urticarial vasculitis and Lyme disease. J Am Acad Dermatol. 1990;22(6 Pt 1):1114-6. [PubMed] Olson JC, Esterly NB.
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63.) Lyme borreliosis: aspects of tick-borne Borrelia burgdorferi infection from a dermatologic viewpoint. Semin Dermatol. 1990;9(4):277-91. [PubMed]Asbrink E, Hovmark A.

64.) Exploring the association between Morgellons disease and Lyme disease: identification of Borrelia burgdorferi in Morgellons disease patients. BMC Dermatol. 2015 Feb 12;15:1. [PubMed] Middelveen MJ, Bandoski C, Burke J, Sapi E, Filush KR, Wang Y, Franco A, Mayne P, Stricker RB.

65.) Lyme Borreliosis and Skin. Indian J Dermatol. 2013; 58(3):167–174. [PubMed]  Vasudevan B, Chatterjee M.
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66.) Diffuse reversible alopecia in patients with Lyme meningitis and tick-borne encephalitis. Wiener klinische Wochenschrift. 2000;111:976–7. [PubMed] Cimperman J, Maraspin V, Lotric-Furlan S, Ruzic-Sabljic E, Avsic-Zupanc T, Strle F.

67.) Lichen sclerosus et atrophicans, scleroderma en coup de sabre and Lyme borreliosis. Dermatol Reports. 2011;28;3(2):e27.
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68.) Lyme disease in central Europe. Curr Opin Infect Dis. 2001;14(2):133-7. [PubMed]  Hercogová J, Brzonova I.

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70.) Anetoderma: another facet of Lyme disease? J Am Acad Dermatol. 2003;48(5 Suppl):S86-8. [PubMed]Bauer J1, Leitz G, Palmedo G, Hügel H.

71.) Clinical spectrum of skin manifestations of Lyme borreliosis in 204 children in Austria. Acta Derm Venereol. 2015;95(5):565-71. [PubMed]  Glatz M, Resinger A, Semmelweis K, Ambros-Rudolph CM, Müllegger RR.

72.) Primary and secondary erythema migrans in central Wisconsin. Arch Dermatol. 1993;129(6):709-16. [PubMed] Melski JW, Reed KD, Mitchell PD, Barth GD.
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7.) LYME DISEASE LATE STAGE: MENINGITIS, OCULOPATHY, IRIDOCYCLITIS, IRITIS,UVEITIS
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73.)  Neurologic manifestations in children with Lyme disease. Pediatrics. 1995;96:1053-1056. [PubMed] Bingham PM, Galetta SL, Athreya B, Sladky J.

74.)Chronic and recurrent meningitis. Pract Neurol. 2008 Dec;8(6):348-61. Review doi: 10.1136/jnnp.2008.157396. [PubMed]  Ginsberg L, Kidd D.

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78.) The expanding clinical spectrum of ocular lyme borreliosis. Ophthalmology 2000;107:581-587. [PubMed] Mikkilä HO, Seppala IJ, Viljanen MK, Peltomaa MP, Karma A.

79.) Ocular manifestations of tick-borne diseases. Surv Ophthalmol. 2016;61(6):726-744. Review. doi: 10.1016/j.survophthal.2016.03.011. [PubMed] Raja H, Starr MR, Bakri SJ.

80.) The eye and tick-borne disease in the United States. Curr Opin Ophthalmol. 2016;27(6):530-537. Review. DOI: 10.1097/ICU.0000000000000308 [PubMed] Sathiamoorthi S, Smith WM.

81.) Iritis and papillitis as a primary presentation of Lyme disease. Ann Ophthalmol. 1990;22(1):24-5. [PubMed] Boutros A, Rahn E, Nauheim R.

82.) [Ocular manifestations of Lyme borreliosis in northwest Croatia]. Lijec Vjesn. 2004;126(5-6):124-8. [Article in Croatian] [PubMed]  Golubic D, Vinkovic T, Turk D, Hranilovic J, Slugan I.

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8.) LYME DISEASE SECONDARY AND LATE STAGE: NEPHRITIS, HEPATITIS, LYMPHADENOPATHY, MYOSITIS AND OTHER.
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85.) Comment on 'Membranous glomerulonephritis secondary to Borrelia burgdorferi infection presenting as nephrotic syndrome'. Nephrology Dialysis Transplantation. 2010;25(5):1723-1727. doi:10.1093/ndt/gfq028. [PubMed]  Kirmizis D, Chatzidimitriou D.

86.) Renal Manifestations of Lyme Disease: Interplay between Infection and Immunostimulation. In: Holmgren A, Borg G, ed. Handbook Of Disease Outbreaks: Prevention, Detection And Control. 1st ed. New York: Nova Science Publishers Inc; 2010. https://www.novapublishers.com/catalog/product_info.php?products_id=11009]  Kirmizis D, Chatzidimitriou D.

87.) MPGN secondary to lyme disease. American Journal of Kidney Diseases. 2004;43(3):544-551. doi:10.1053/j.ajkd.2003.11.014. [PubMed] Kirmizis D, Efstratiadis G, Economidou D, Diza-Mataftsi E, Leontsini M, Memmos D.

88.) Minimal-Change Disease Secondary toBorrelia burgdorferiInfection. Case Reports in Nephrology. 2012;2012:1-3. doi:10.1155/2012/294532. [PubMed]  Kwiatkowska E, Golembiewska E, Ciechanowski K, Kedzierska K.

89.) Lyme disease-associated glomerulonephritis. Nephrology Dialysis Transplantation. 2011;26(9):3054-3056. doi:10.1093/ndt/gfr335. [PubMed]  Mc Causland F, Niedermaier S, Bijol V, Rennke H, Choi M, Forman J.

90.) Membranous glomerulonephritis secondary to Borrelia burgdorferi infection presenting as nephrotic syndrome. Clinical Kidney Journal. 2009;3(1):105-106. doi:10.1093/ndtplus/sfp160. [PubMed] Papineni P, Doherty T, Pickett T, Toth T, Boddana P.

91.) MPGN and Nephrotic Syndrome (NS) Secondary to Lyme Disease (LD). American Journal of Kidney Diseases. 2008;51(4):B83. doi:10.1053/j.ajkd.2008.02.231. [http://www.ajkd.org/article/S0272-6386(08)00402-2/abstract]  Rawal B, Rovner L, Thakar C, Pollock J.

92.) Penetration of endothelial cell monolayers by Borrelia burgdorferi, Infect Immun , 1989, vol. 57 (pg. 1626-8)  [PubMed] Comstock LE, Thomas DD.

93.) Goellner MH, Agger WA, Burgess JH, Duray PH. Hepatitis due to recurrent Lyme disease, Ann Intern Med , 1988, vol. 108 (pg. 707-8) [PubMed]Goellner MH, Agger WA, Burgess JH, Duray PH.

94.) Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joint, heart and liver, Am J Pathol, 1990, vol. 137 (pg. 811-20) [PubMed] Schaible UE, Gay S, Museteanu C, et al.

95.) Gastrointestinal and Hepatic Manifestations of Tickborne Diseases in the United States. Clin Infect Dis. 2002:34(9):1206-1212. DOI:https://doi.org/10.1086/339871 [PubMed] Zaidi SA, Singer C.

96.)[A reprospective analysis of 973 patients with lyme borreliosis in Kuyavian-Pomeranian voivodship in 2000-2005]. [Article in Polish] Przegl Epidemiol. 2012;66(4):581-6. [PubMed]  Blazejewicz-Zawadziniska M, Brochocka A, Lisinska J, Borowiecki M.

97.) Lymphoadenopathy during lyme borreliosis is caused by spirochete migration-induced specific B cell activation. PLoS Pathog. 2011;7(5):e1002066. doi: 10.1371/journal.ppat.1002066. [PubMed] Tunev SS, Hastey CJ, Hodzic E, Feng S, Barthold SW, Baumgarth N.

98.)[Clinico-epidemiologic characteristics of Lyme disease treated at the Infectious Disease in Novy Sad 1993-1998]. [Article in Croatian] Med Pregl. 2001;54(9-10):470-5. [PubMed]  Vukadinov J1, Canak G, Brkic S, Samardzija NM, Aleksic-Dordevic M, Turkulov V, Cik-Nad E, Lalosevic V.

99.) Borrelia arthritis and chronic myositis accompanied by typical chronic dermatitis. JBR-BTR. 2008;91(3):88-9. [PubMed]  Brtkova J, Jirickova P, Kapla J, Dedic K, Pliskova L.

100.) Orbital myositis associated with Borrelia burgdorferi (Lyme disease) infection. Ophthalmology. 2004;111(5):1023-8. DOI: 10.1016/j.ophtha.2003.08.032. [PubMed] Carvounis PE, Mehta AP, Geist CE.

101.) Tick inoculation in an eyelid region: report on five cases with one complication of the orbital myositis associated with Lyme borreliosis. Klin Oczna. 2006;108(4-6):220-4. [PubMed]  Holak H, Holak N, Huzarska M, Holak S.

102.) Lyme myositis. Arthritis Rheum. 2006;54(8):2697-700. [PubMed] Holmgren AR, Matteson EL.

103.) Two cases of orbital myositis as a rare feature of lyme borreliosis. Case Rep Infect Dis. 2011;2011:372470. doi: 10.1155/2011/372470. [PubMed] Sauer A, Speeg-Schatz C, Hansmann Y.

104.) [Lyme disease could mimic dermatomyositis]. [Article in French] Rev Med Interne. 2007 May;28(5):343-5. [PubMed] Waton J, Pinault AL, Pouaha J, Truchetet F.

105.) Late Diagnosis of Early Disseminated Lyme Disease: Perplexing Symptoms in a Gardener, J Am Board Fam Med May-June 2008 vol. 21 no. 3 234-236 [PubMed] doi: 10.3122/jabfm.2008.03.070196 Brooke E. Salzman, MD, Amber Stonehouse, MD and James Studdiford, MD

106.) Pancytopenia in Lyme disease. BMJ Case Rep. 2014;4;2014. pii: bcr2013201079. doi: 10.1136/bcr-2013-201079. [PubMed]  Mehrzad R, Bravoco J.

107.) The eye and tick-borne disease in the United States. Curr Opin Ophthalmol. 2016 Nov;27(6):530-537. [PubMed]  Sathiamoorthi S, Smith W.
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9.) LYME DISEASE LATE STAGE AND CARDIOVASCULARY DISEASE.
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108.) Coronary aneurysm in Lyme disease: Treatment by covered stent. International Journal of Cardiology. 2008;128(2):e72–e73. doi:10.1016/j.ijcard.2007.04.163. [PubMed] Cuisset T, Hamilos M, Vanderheyden M.

109.) Coronary artery aneurysm in two patients with long-standing Lyme borreliosis. The Lancet. 1994;344(8932):1300-1301. doi:10.1016/s0140-6736(94)90789-7. [PubMed] Gasser R, Watzinger N, Eber B et al.

110.) Presence of Borrelia burgdorferi sensu lato antibodies in the serum of patients with abdominal aortic aneurysms. Eur J Clin Microbiol Infect Dis. 2012 May;31(5):781-9. doi: 10.1007/s10096-011-1375-y. Epub 2011 Aug 13. [PubMed] Hinterseher I1, Gäbel G, Corvinus F, Lück C, Saeger HD, Bergert H, Tromp G, Kuivaniemi H.

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112.) Ascending aortitis: a clinicopathological study of 21 cases in a series of 300 aortic repairs. Pathology. 2014 Jun;46(4):296-305. doi: 10.1097/PAT.0000000000000096. [PubMed]  Xu L1, Heath J, Burke A.

113.) Coronary artery aneurysm in two patients with long-standing Lyme borreliosis. Borreliosis Study Group. Lancet. 1994;344:1300–1301. doi: 10.1016/S0140-6736(94)90789-7. [PubMed] [Cross Ref] Gasser R, Watzinger N, Eber B, Luha O, Reisinger E, Seinost G, Klein W.

114.) Peroperative cardiogenic shock suggesting acute coronary syndrome as initial manifestation of Lyme carditis. J Clin Anesth. 2016 Dec;35:430-433. doi: 10.1016/j.jclinane.2016.08.005. Epub 2016 Oct 18. [PubMed] Clinckaert C, Bidgoli S, Verbeet T, Attou R, Gottignies P, Massaut J, Reper P.

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118.) Peroperative cardiogenic shock suggesting acute coronary syndrome as initial manifestation of Lyme carditis. Journal of Clinical Anesthesia. 2016;35:430–433. doi:10.1016/j.jclinane.2016.08.005. [PubMed]  Clinckaert C, Bidgoli S, Verbeet T, et al.

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123.) Detection of Borrelia burgdorferi sensu lato in endomyocardial biopsy specimens in individuals with recent-onset dilated cardiomyopathy. European Journal of Heart Failure. 2012;14(6):588–596. doi:10.1093/eurjhf/hfs027. [PubMed] Kubánek M, Šramko M, Berenová D, et al.

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10.) LYME DISEASE LATE STAGE, NEURO-BORRELIOSIS, NEURITIS OR NEUROPATHY, MENINGOVASCULAR, NB WITH CEREBRAL INFARCTS, LYME PARKINSONISM, LYME ENCEPHALITIS.
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129.) Lyme disease –induced polyradiculopathy mimicking amyotrophic lateral sclerosis. Inter J of Neuroscience. 2014;124(11):859–862. doi:10.3109/00207454.2013.879582. [PubMed] Burakgazi AZ.

130.) Clinical and epidemiological features of Lyme borreliosis in Bulgaria. Wien Klin Wochenschr. 2004;116(1-2):42-6. [PubMed]  Christova I, Komitova R.

131.)  Seronegative Chronic Relapsing Neuroborreliosis. Eur Neurol 1995;35:113-117. [PubMed] Lawrence C, Lipton RB, Lowy FD, Coyle PK.

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134.) Avellis syndrome due to borreliosis. Eur J Neurol. 2007;14(1):112-4. DOI: 10.1111/j.1468-1331.2006.01528.x. [PubMed] Habek M, Mubrin Z, Brinar VV.

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136.)  Retrobulbar optic neuritis: a complication of Lyme disease? J Neurol Neurosurg Psychiatry. 2007;78(12): 1409–1410. doi: 10.1136/jnnp.2006.113761. [PubMed Central] Krim E, Guehl D, Burbaud P, and LaguenyA.

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138.) Optic neuropathy in children with Lyme disease. Pediatrics. 200;108(2):477-81. [PubMed]  Rothermel H, Hedges TR 3rd, Steere AC.

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151.) Borrelia rhombencephalomyelopathy. Arch Neurol. 1991;48:832–6. [PubMed] Kuntzer T, Bogousslavsky J, Miklossy J, Steck AJ, Janzer R, Regli F.

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157.) Meningovascular form of neuroborreliosis: similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. Acta Neuropathol. 1990;80:568–72. [PubMed]  Miklossy J, Kuntzer T, Bogousslavsky J, Regli F, Janzer RC.

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12.) LYME DISEASE- LATE STAGE: ATROPHIC FORM OF LYME MENINGOENCEPHALITIS WITH DEMENTIA & SUBACUTE PRESENILE DEMENTIA & NEUROPSYCHIATRIC MANIFESTATIONS
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